Precancer exercise capacity and metabolism during tumor development coordinate the skeletal muscle-tumor metabolic competition.

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Title: Precancer exercise capacity and metabolism during tumor development coordinate the skeletal muscle-tumor metabolic competition.
Authors: Leitner BP; Department of Cellular & Molecular Physiology, Yale University, New Haven, CT 06510.; Department of Internal Medicine, Yale University, New Haven, CT 06510., Fosam AE; Department of Cellular & Molecular Physiology, Yale University, New Haven, CT 06510.; Department of Internal Medicine, Yale University, New Haven, CT 06510., Lee WD; Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 06540.; Department of Chemistry, Princeton University, Princeton, NJ 06540.; Ludwig Institute for Cancer Research, Princeton Branch, Princeton, NJ 06540., Zilinger K; Department of Cellular & Molecular Physiology, Yale University, New Haven, CT 06510.; Department of Internal Medicine, Yale University, New Haven, CT 06510., Nakandakari SCBR; Department of Cellular & Molecular Physiology, Yale University, New Haven, CT 06510.; Department of Internal Medicine, Yale University, New Haven, CT 06510., Zhang X; Department of Cellular & Molecular Physiology, Yale University, New Haven, CT 06510.; Department of Internal Medicine, Yale University, New Haven, CT 06510., Gaspar RC; Department of Cellular & Molecular Physiology, Yale University, New Haven, CT 06510.; Department of Internal Medicine, Yale University, New Haven, CT 06510., Zhu W; Department of Cellular & Molecular Physiology, Yale University, New Haven, CT 06510.; Department of Internal Medicine, Yale University, New Haven, CT 06510., Perry CJ; Department of Internal Medicine, Yale University, New Haven, CT 06510., Rabinowitz JD; Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 06540.; Department of Chemistry, Princeton University, Princeton, NJ 06540.; Ludwig Institute for Cancer Research, Princeton Branch, Princeton, NJ 06540.; Department of Molecular Biology, Princeton University, Princeton, NJ 06540., Perry RJ; Department of Cellular & Molecular Physiology, Yale University, New Haven, CT 06510.; Department of Internal Medicine, Yale University, New Haven, CT 06510.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2025 Dec 09; Vol. 122 (49), pp. e2508707122. Date of Electronic Publication: 2025 Dec 01.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1091-6490
DOI:10.1073/pnas.2508707122