Antigen-specific CD8+CD39+ cytotoxic T cell density in the microenvironment of hepatocellular carcinoma predicts patient survival.

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Title: Antigen-specific CD8+CD39+ cytotoxic T cell density in the microenvironment of hepatocellular carcinoma predicts patient survival.
Authors: Dimopoulou K; Department of Gastroenterology, Red Cross Hospital, Athens, Greece., Spathis A; 2nd Department of Pathology, National and Kapodistrian University of Athens, Medical School, Attikon University Hospital, Athens, Greece., Papamichail C; 2nd Department of Pathology, National and Kapodistrian University of Athens, Medical School, Attikon University Hospital, Athens, Greece., Athanasiadou A; 2nd Department of Pathology, National and Kapodistrian University of Athens, Medical School, Attikon University Hospital, Athens, Greece., Pouliakis A; 2nd Department of Pathology, National and Kapodistrian University of Athens, Medical School, Attikon University Hospital, Athens, Greece., Risilia C; 2nd Department of Pathology, National and Kapodistrian University of Athens, Medical School, Attikon University Hospital, Athens, Greece., Myoteri D; Department of Pathology, National and Kapodistrian University of Athens, Medical School, Aretaieion Hospital, Athens, Greece., Kokoropoulos P; 4th Department of Surgery, National and Kapodistrian University of Athens, Medical School, Attikon University Hospital, Athens, Greece., Konstantoulakis M; 2nd Department of Surgery, National and Kapodistrian University of Athens, Medical School, Aretaieion Hospital, Athens, Greece., Panayiotides IG; 2nd Department of Pathology, National and Kapodistrian University of Athens, Medical School, Attikon University Hospital, Athens, Greece., Arkadopoulos N; 4th Department of Surgery, National and Kapodistrian University of Athens, Medical School, Attikon University Hospital, Athens, Greece., Tiniakos D; Department of Pathology, National and Kapodistrian University of Athens, Medical School, Aretaieion Hospital, Athens, Greece.; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Foukas PG; 2nd Department of Pathology, National and Kapodistrian University of Athens, Medical School, Attikon University Hospital, Athens, Greece. pfoukas@med.uoa.gr.
Source: British journal of cancer [Br J Cancer] 2026 Feb; Vol. 134 (3), pp. 447-456. Date of Electronic Publication: 2025 Dec 01.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group on behalf of Cancer Research UK Country of Publication: England NLM ID: 0370635 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-1827 (Electronic) Linking ISSN: 00070920 NLM ISO Abbreviation: Br J Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1532-1827
DOI:10.1038/s41416-025-03226-8