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Inhibiting Glycan Degradation Prevents HIV-Induced Inflammaging and Cognitive Impairment.

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Title: Inhibiting Glycan Degradation Prevents HIV-Induced Inflammaging and Cognitive Impairment.
Authors: Giron LB; Division of Infectious Diseases, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.; Center for Human Immunobiology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.; Potocsnak Longevity Institute, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA., Borjabad A; Icahn School of Medicine at Mount Sinai, New York, NY; USA., Hadas E; Icahn School of Medicine at Mount Sinai, New York, NY; USA., Granche J; Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA., de Menezes EGM; Vitalant Research Institute, San Francisco, CA, USA.; Department of Laboratory Medicine, University of California, San Francisco, CA, USA., Premeaux TA; Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, New York, NY, USA., He H; Icahn School of Medicine at Mount Sinai, New York, NY; USA., Yeung ST; Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, New York, NY, USA., Singh S; Division of Infectious Diseases, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.; Center for Human Immunobiology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.; Potocsnak Longevity Institute, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA., Friday C; Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, New York, NY, USA., Glover J; University of Pennsylvania, Philadelphia, PA, USA., Balboa E; University of Pennsylvania, Philadelphia, PA, USA., Dopkin D; University of Pennsylvania, Philadelphia, PA, USA., Burrows M; University of Pennsylvania, Philadelphia, PA, USA., Secreto A; University of Pennsylvania, Philadelphia, PA, USA., Skuli N; University of Pennsylvania, Philadelphia, PA, USA., Tateno H; Cellular and Molecular Biotechnology Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki, Japan., Denton PW; University of Nebraska Omaha, Omaha, NE, USA., Palella F; Division of Infectious Diseases, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.; Potocsnak Longevity Institute, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA., Corley MJ; University of California San Diego, San Diego, CA, USA., Ndhlovu LC; Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, New York, NY, USA., Norris PJ; Vitalant Research Institute, San Francisco, CA, USA.; Department of Laboratory Medicine, University of California, San Francisco, CA, USA.; Department of Medicine, University of California, San Francisco, CA, USA., Tassiopoulos K; Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA., Volsky DJ; Icahn School of Medicine at Mount Sinai, New York, NY; USA., Abdel-Mohsen M; Division of Infectious Diseases, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.; Center for Human Immunobiology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.; Potocsnak Longevity Institute, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Nov 17. Date of Electronic Publication: 2025 Nov 17.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Giron+LB%22">Giron LB</searchLink>; Division of Infectious Diseases, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.; Center for Human Immunobiology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.; Potocsnak Longevity Institute, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Borjabad+A%22">Borjabad A</searchLink>; Icahn School of Medicine at Mount Sinai, New York, NY; USA.<br /><searchLink fieldCode="AU" term="%22Hadas+E%22">Hadas E</searchLink>; Icahn School of Medicine at Mount Sinai, New York, NY; USA.<br /><searchLink fieldCode="AU" term="%22Granche+J%22">Granche J</searchLink>; Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22de+Menezes+EGM%22">de Menezes EGM</searchLink>; Vitalant Research Institute, San Francisco, CA, USA.; Department of Laboratory Medicine, University of California, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Premeaux+TA%22">Premeaux TA</searchLink>; Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22He+H%22">He H</searchLink>; Icahn School of Medicine at Mount Sinai, New York, NY; USA.<br /><searchLink fieldCode="AU" term="%22Yeung+ST%22">Yeung ST</searchLink>; Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Singh+S%22">Singh S</searchLink>; Division of Infectious Diseases, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.; Center for Human Immunobiology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.; Potocsnak Longevity Institute, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Friday+C%22">Friday C</searchLink>; Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Glover+J%22">Glover J</searchLink>; University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Balboa+E%22">Balboa E</searchLink>; University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Dopkin+D%22">Dopkin D</searchLink>; University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Burrows+M%22">Burrows M</searchLink>; University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Secreto+A%22">Secreto A</searchLink>; University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Skuli+N%22">Skuli N</searchLink>; University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Tateno+H%22">Tateno H</searchLink>; Cellular and Molecular Biotechnology Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki, Japan.<br /><searchLink fieldCode="AU" term="%22Denton+PW%22">Denton PW</searchLink>; University of Nebraska Omaha, Omaha, NE, USA.<br /><searchLink fieldCode="AU" term="%22Palella+F%22">Palella F</searchLink>; Division of Infectious Diseases, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.; Potocsnak Longevity Institute, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Corley+MJ%22">Corley MJ</searchLink>; University of California San Diego, San Diego, CA, USA.<br /><searchLink fieldCode="AU" term="%22Ndhlovu+LC%22">Ndhlovu LC</searchLink>; Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Norris+PJ%22">Norris PJ</searchLink>; Vitalant Research Institute, San Francisco, CA, USA.; Department of Laboratory Medicine, University of California, San Francisco, CA, USA.; Department of Medicine, University of California, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Tassiopoulos+K%22">Tassiopoulos K</searchLink>; Harvard T. 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