Lymphotoxin-driven cancer cell eradication by tumoricidal CD8+ TIL.

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Bibliographic Details
Title: Lymphotoxin-driven cancer cell eradication by tumoricidal CD8+ TIL.
Authors: Xie H; Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Jiang A; Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Dey A; Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA, USA., Dean JW; Iovance Biotherapeutics, Inc., San Carlos, CA, USA., Perera JJ; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Smith NP; Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA, USA., Chen ACY; Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA, USA., Anderson S; Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Cicerchia AM; Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Sun Y; Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Michaud WA; Division of Gastrointestinal and Oncologic Surgery, Department of Surgery, Massachusetts General Hospital, Boston, MA, USA., Florentin M; Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Fang J; Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Revach OY; Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Sharova T; Division of Gastrointestinal and Oncologic Surgery, Department of Surgery, Massachusetts General Hospital, Boston, MA, USA., Lawless A; Division of Gastrointestinal and Oncologic Surgery, Department of Surgery, Massachusetts General Hospital, Boston, MA, USA., Xu KH; Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Song Y; Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Patel B; Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Stevens JD; Department of Pathology, Brigham and Women's Hospital, Boston, MA 02215, USA., Lane WJ; Department of Pathology, Brigham and Women's Hospital, Boston, MA 02215, USA., Keskin DB; Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Translational Immunogenomics Laboratory, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Department of Computer Science, Metropolitan College, Boston University, Boston, Massachusetts, USA.; Section for Bioinformatics, Department of Health Technology, Technical University of Denmark, Lyngby, Denmark., Cohen S; Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Division of Gastrointestinal and Oncologic Surgery, Department of Surgery, Massachusetts General Hospital, Boston, MA, USA., Lawrence DP; Harvard Medical School, Boston, MA, USA.; Mass General Cancer Center, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Sullivan RJ; Harvard Medical School, Boston, MA, USA.; Mass General Cancer Center, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Flaherty KT; Harvard Medical School, Boston, MA, USA.; Mass General Cancer Center, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Boland GM; Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Division of Gastrointestinal and Oncologic Surgery, Department of Surgery, Massachusetts General Hospital, Boston, MA, USA., Nieman LT; Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Sade-Feldman M; Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Hacohen N; Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Sen DR; Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Wu C; Harvard Medical School, Boston, MA, USA.; Translational Immunogenomics Laboratory, Dana-Farber Cancer Institute, Boston, Massachusetts, USA., Gastman B; Iovance Biotherapeutics, Inc., San Carlos, CA, USA., Qi R; Iovance Biotherapeutics, Inc., San Carlos, CA, USA., Yin H; Iovance Biotherapeutics, Inc., San Carlos, CA, USA., Villani AC; Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA, USA., Manguso RT; Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Jenkins RW; Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Mass General Cancer Center, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Present address: Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Nov 20. Date of Electronic Publication: 2025 Nov 20.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2692-8205
DOI:10.1101/2025.11.19.689204