Lymphotoxin-driven cancer cell eradication by tumoricidal CD8+ TIL.
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| Title: | Lymphotoxin-driven cancer cell eradication by tumoricidal CD8+ TIL. |
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| Authors: | Xie H; Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Jiang A; Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Dey A; Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA, USA., Dean JW; Iovance Biotherapeutics, Inc., San Carlos, CA, USA., Perera JJ; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Smith NP; Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA, USA., Chen ACY; Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA, USA., Anderson S; Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Cicerchia AM; Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Sun Y; Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Michaud WA; Division of Gastrointestinal and Oncologic Surgery, Department of Surgery, Massachusetts General Hospital, Boston, MA, USA., Florentin M; Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Fang J; Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Revach OY; Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Sharova T; Division of Gastrointestinal and Oncologic Surgery, Department of Surgery, Massachusetts General Hospital, Boston, MA, USA., Lawless A; Division of Gastrointestinal and Oncologic Surgery, Department of Surgery, Massachusetts General Hospital, Boston, MA, USA., Xu KH; Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Song Y; Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Patel B; Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Stevens JD; Department of Pathology, Brigham and Women's Hospital, Boston, MA 02215, USA., Lane WJ; Department of Pathology, Brigham and Women's Hospital, Boston, MA 02215, USA., Keskin DB; Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Translational Immunogenomics Laboratory, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Department of Computer Science, Metropolitan College, Boston University, Boston, Massachusetts, USA.; Section for Bioinformatics, Department of Health Technology, Technical University of Denmark, Lyngby, Denmark., Cohen S; Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Division of Gastrointestinal and Oncologic Surgery, Department of Surgery, Massachusetts General Hospital, Boston, MA, USA., Lawrence DP; Harvard Medical School, Boston, MA, USA.; Mass General Cancer Center, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Sullivan RJ; Harvard Medical School, Boston, MA, USA.; Mass General Cancer Center, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Flaherty KT; Harvard Medical School, Boston, MA, USA.; Mass General Cancer Center, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Boland GM; Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Division of Gastrointestinal and Oncologic Surgery, Department of Surgery, Massachusetts General Hospital, Boston, MA, USA., Nieman LT; Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Sade-Feldman M; Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Hacohen N; Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Sen DR; Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Wu C; Harvard Medical School, Boston, MA, USA.; Translational Immunogenomics Laboratory, Dana-Farber Cancer Institute, Boston, Massachusetts, USA., Gastman B; Iovance Biotherapeutics, Inc., San Carlos, CA, USA., Qi R; Iovance Biotherapeutics, Inc., San Carlos, CA, USA., Yin H; Iovance Biotherapeutics, Inc., San Carlos, CA, USA., Villani AC; Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA, USA., Manguso RT; Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Jenkins RW; Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Mass General Cancer Center, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Present address: Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina, USA. |
| Source: | BioRxiv : the preprint server for biology [bioRxiv] 2025 Nov 20. Date of Electronic Publication: 2025 Nov 20. |
| Publication Type: | Journal Article; Preprint |
| Journal Info: | Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41332750 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Lymphotoxin-driven cancer cell eradication by tumoricidal CD8<superscript>+</superscript> TIL. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Xie+H%22">Xie H</searchLink>; Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Jiang+A%22">Jiang A</searchLink>; Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Dey+A%22">Dey A</searchLink>; Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Dean+JW%22">Dean JW</searchLink>; Iovance Biotherapeutics, Inc., San Carlos, CA, USA.<br /><searchLink fieldCode="AU" term="%22Perera+JJ%22">Perera JJ</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Smith+NP%22">Smith NP</searchLink>; Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Chen+ACY%22">Chen ACY</searchLink>; Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Anderson+S%22">Anderson S</searchLink>; Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Cicerchia+AM%22">Cicerchia AM</searchLink>; Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Sun+Y%22">Sun Y</searchLink>; Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Michaud+WA%22">Michaud WA</searchLink>; Division of Gastrointestinal and Oncologic Surgery, Department of Surgery, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Florentin+M%22">Florentin M</searchLink>; Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Fang+J%22">Fang J</searchLink>; Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Revach+OY%22">Revach OY</searchLink>; Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Sharova+T%22">Sharova T</searchLink>; Division of Gastrointestinal and Oncologic Surgery, Department of Surgery, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Lawless+A%22">Lawless A</searchLink>; Division of Gastrointestinal and Oncologic Surgery, Department of Surgery, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Xu+KH%22">Xu KH</searchLink>; Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Song+Y%22">Song Y</searchLink>; Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Patel+B%22">Patel B</searchLink>; Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Stevens+JD%22">Stevens JD</searchLink>; Department of Pathology, Brigham and Women's Hospital, Boston, MA 02215, USA.<br /><searchLink fieldCode="AU" term="%22Lane+WJ%22">Lane WJ</searchLink>; Department of Pathology, Brigham and Women's Hospital, Boston, MA 02215, USA.<br /><searchLink fieldCode="AU" term="%22Keskin+DB%22">Keskin DB</searchLink>; Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Translational Immunogenomics Laboratory, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Department of Computer Science, Metropolitan College, Boston University, Boston, Massachusetts, USA.; Section for Bioinformatics, Department of Health Technology, Technical University of Denmark, Lyngby, Denmark.<br /><searchLink fieldCode="AU" term="%22Cohen+S%22">Cohen S</searchLink>; Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Division of Gastrointestinal and Oncologic Surgery, Department of Surgery, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Lawrence+DP%22">Lawrence DP</searchLink>; Harvard Medical School, Boston, MA, USA.; Mass General Cancer Center, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Sullivan+RJ%22">Sullivan RJ</searchLink>; Harvard Medical School, Boston, MA, USA.; Mass General Cancer Center, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Flaherty+KT%22">Flaherty KT</searchLink>; Harvard Medical School, Boston, MA, USA.; Mass General Cancer Center, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Boland+GM%22">Boland GM</searchLink>; Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Division of Gastrointestinal and Oncologic Surgery, Department of Surgery, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Nieman+LT%22">Nieman LT</searchLink>; Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Sade-Feldman+M%22">Sade-Feldman M</searchLink>; Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Hacohen+N%22">Hacohen N</searchLink>; Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Sen+DR%22">Sen DR</searchLink>; Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Wu+C%22">Wu C</searchLink>; Harvard Medical School, Boston, MA, USA.; Translational Immunogenomics Laboratory, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Gastman+B%22">Gastman B</searchLink>; Iovance Biotherapeutics, Inc., San Carlos, CA, USA.<br /><searchLink fieldCode="AU" term="%22Qi+R%22">Qi R</searchLink>; Iovance Biotherapeutics, Inc., San Carlos, CA, USA.<br /><searchLink fieldCode="AU" term="%22Yin+H%22">Yin H</searchLink>; Iovance Biotherapeutics, Inc., San Carlos, CA, USA.<br /><searchLink fieldCode="AU" term="%22Villani+AC%22">Villani AC</searchLink>; Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Manguso+RT%22">Manguso RT</searchLink>; Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Jenkins+RW%22">Jenkins RW</searchLink>; Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Mass General Cancer Center, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Present address: Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina, USA. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101680187%22">BioRxiv : the preprint server for biology</searchLink> [bioRxiv] 2025 Nov 20. <i>Date of Electronic Publication: </i>2025 Nov 20. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Preprint – Name: TitleSource Label: Journal Info Group: Src Data: <i>Country of Publication: </i>United States <i>NLM ID: </i>101680187 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2692-8205 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2226928205%22">26928205 </searchLink><i>NLM ISO Abbreviation: </i>bioRxiv <i>Subsets: </i>PubMed not MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41332750 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1101/2025.11.19.689204 Languages: – Code: eng Text: English Titles: – TitleFull: Lymphotoxin-driven cancer cell eradication by tumoricidal CD8+ TIL. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Xie H – PersonEntity: Name: NameFull: Jiang A – PersonEntity: Name: NameFull: Dey A – PersonEntity: Name: NameFull: Dean JW – PersonEntity: Name: NameFull: Perera JJ – PersonEntity: Name: NameFull: Smith NP – PersonEntity: Name: NameFull: Chen ACY – PersonEntity: Name: NameFull: Anderson S – PersonEntity: Name: NameFull: Cicerchia AM – PersonEntity: Name: NameFull: Sun Y – PersonEntity: Name: NameFull: Michaud WA – PersonEntity: Name: NameFull: Florentin M – PersonEntity: Name: NameFull: Fang J – PersonEntity: Name: NameFull: Revach OY – PersonEntity: Name: NameFull: Sharova T – PersonEntity: Name: NameFull: Lawless A – PersonEntity: Name: NameFull: Xu KH – PersonEntity: Name: NameFull: Song Y – PersonEntity: Name: NameFull: Patel B – PersonEntity: Name: NameFull: Stevens JD – PersonEntity: Name: NameFull: Lane WJ – PersonEntity: Name: NameFull: Keskin DB – PersonEntity: Name: NameFull: Cohen S – PersonEntity: Name: NameFull: Lawrence DP – PersonEntity: Name: NameFull: Sullivan RJ – PersonEntity: Name: NameFull: Flaherty KT – PersonEntity: Name: NameFull: Boland GM – PersonEntity: Name: NameFull: Nieman LT – PersonEntity: Name: NameFull: Sade-Feldman M – PersonEntity: Name: NameFull: Hacohen N – PersonEntity: Name: NameFull: Sen DR – PersonEntity: Name: NameFull: Wu C – PersonEntity: Name: NameFull: Gastman B – PersonEntity: Name: NameFull: Qi R – PersonEntity: Name: NameFull: Yin H – PersonEntity: Name: NameFull: Villani AC – PersonEntity: Name: NameFull: Manguso RT – PersonEntity: Name: NameFull: Jenkins RW IsPartOfRelationships: – BibEntity: Dates: – D: 20 M: 11 Text: 2025 Nov 20 Type: published Y: 2025 Identifiers: – Type: issn-electronic Value: 2692-8205 Titles: – TitleFull: BioRxiv : the preprint server for biology Type: main |
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