Toll-like receptor 1 polymorphism is associated with impaired immune tolerance, dysregulated inflammatory responses to Borrelia burgdorferi, and heightened risk of post-infectious Lyme arthritis.

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Title: Toll-like receptor 1 polymorphism is associated with impaired immune tolerance, dysregulated inflammatory responses to Borrelia burgdorferi, and heightened risk of post-infectious Lyme arthritis.
Authors: Williams MA; Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA, United States., Hernandez SA; Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA, United States., Arvikar SL; Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States., Sulka KB; Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA, United States., Strle F; Department of Infectious Diseases, University Medical Centre Ljubljana, Ljubljana, Slovenia., Wells CC; Department of Immunology, Tufts University Graduate School of Biomedical Sciences, Boston, MA, United States., Petnicki-Ocwieja T; Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA, United States., Steere AC; Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States., Strle K; Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA, United States.
Source: Frontiers in immunology [Front Immunol] 2025 Nov 17; Vol. 16, pp. 1711765. Date of Electronic Publication: 2025 Nov 17 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1664-3224
DOI:10.3389/fimmu.2025.1711765