A BRET biosensor for measuring uncompetitive engagement of PRMT5 complexes in cells.
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| Title: | A BRET biosensor for measuring uncompetitive engagement of PRMT5 complexes in cells. |
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| Authors: | Rothweiler EM; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, UK.; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, UK., Michaud A; Promega Corporation, Madison, WI, USA., Stefaniak J; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, UK.; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, UK., Singh U; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, UK.; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, UK., Mikulsky BB; Promega Corporation, Madison, WI, USA., Vasta JD; Promega Corporation, Madison, WI, USA., Beck MT; Promega Corporation, Madison, WI, USA., Wilkinson J; Promega Corporation, Madison, WI, USA., Ward JA; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, UK.; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, UK., Rogers CM; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, UK.; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, UK., Balıkçı E; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, UK.; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, UK., Tranberg-Jensen J; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, UK.; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, UK., Hansen JS; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, UK.; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, UK., Loppnau P; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada., Whitty A; Department of Chemistry, Boston University, Boston, MA, USA., Brennan PE; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, UK.; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, UK.; Alzheimer's Research UK Oxford Drug Discovery Institute, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, UK., Tonge PJ; Center for Advanced Study of Drug Action, Department of Chemistry, Stony Brook University, Stony Brook, NY, USA. peter.tonge@stonybrook.edu.; Department of Biomedical Genetics, University of Rochester, Rochester, NY, USA. peter.tonge@stonybrook.edu., Robers MB; Promega Corporation, Madison, WI, USA. matt.robers@promega.com., Huber KVM; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, UK. kilian.huber@cmd.ox.ac.uk.; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, UK. kilian.huber@cmd.ox.ac.uk. |
| Source: | Nature communications [Nat Commun] 2025 Dec 03; Vol. 16 (1), pp. 10129. Date of Electronic Publication: 2025 Dec 03. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-025-65558-6 |
