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A BRET biosensor for measuring uncompetitive engagement of PRMT5 complexes in cells.

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Title: A BRET biosensor for measuring uncompetitive engagement of PRMT5 complexes in cells.
Authors: Rothweiler EM; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, UK.; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, UK., Michaud A; Promega Corporation, Madison, WI, USA., Stefaniak J; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, UK.; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, UK., Singh U; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, UK.; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, UK., Mikulsky BB; Promega Corporation, Madison, WI, USA., Vasta JD; Promega Corporation, Madison, WI, USA., Beck MT; Promega Corporation, Madison, WI, USA., Wilkinson J; Promega Corporation, Madison, WI, USA., Ward JA; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, UK.; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, UK., Rogers CM; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, UK.; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, UK., Balıkçı E; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, UK.; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, UK., Tranberg-Jensen J; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, UK.; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, UK., Hansen JS; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, UK.; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, UK., Loppnau P; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada., Whitty A; Department of Chemistry, Boston University, Boston, MA, USA., Brennan PE; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, UK.; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, UK.; Alzheimer's Research UK Oxford Drug Discovery Institute, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, UK., Tonge PJ; Center for Advanced Study of Drug Action, Department of Chemistry, Stony Brook University, Stony Brook, NY, USA. peter.tonge@stonybrook.edu.; Department of Biomedical Genetics, University of Rochester, Rochester, NY, USA. peter.tonge@stonybrook.edu., Robers MB; Promega Corporation, Madison, WI, USA. matt.robers@promega.com., Huber KVM; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, UK. kilian.huber@cmd.ox.ac.uk.; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, UK. kilian.huber@cmd.ox.ac.uk.
Source: Nature communications [Nat Commun] 2025 Dec 03; Vol. 16 (1), pp. 10129. Date of Electronic Publication: 2025 Dec 03.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: A BRET biosensor for measuring uncompetitive engagement of PRMT5 complexes in cells.
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  Data: <searchLink fieldCode="AU" term="%22Rothweiler+EM%22">Rothweiler EM</searchLink>; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, UK.; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Michaud+A%22">Michaud A</searchLink>; Promega Corporation, Madison, WI, USA.<br /><searchLink fieldCode="AU" term="%22Stefaniak+J%22">Stefaniak J</searchLink>; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, UK.; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Singh+U%22">Singh U</searchLink>; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, UK.; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Mikulsky+BB%22">Mikulsky BB</searchLink>; Promega Corporation, Madison, WI, USA.<br /><searchLink fieldCode="AU" term="%22Vasta+JD%22">Vasta JD</searchLink>; Promega Corporation, Madison, WI, USA.<br /><searchLink fieldCode="AU" term="%22Beck+MT%22">Beck MT</searchLink>; Promega Corporation, Madison, WI, USA.<br /><searchLink fieldCode="AU" term="%22Wilkinson+J%22">Wilkinson J</searchLink>; Promega Corporation, Madison, WI, USA.<br /><searchLink fieldCode="AU" term="%22Ward+JA%22">Ward JA</searchLink>; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, UK.; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Rogers+CM%22">Rogers CM</searchLink>; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, UK.; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Balıkçı+E%22">Balıkçı E</searchLink>; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, UK.; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Tranberg-Jensen+J%22">Tranberg-Jensen J</searchLink>; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, UK.; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Hansen+JS%22">Hansen JS</searchLink>; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, UK.; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Loppnau+P%22">Loppnau P</searchLink>; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Whitty+A%22">Whitty A</searchLink>; Department of Chemistry, Boston University, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Brennan+PE%22">Brennan PE</searchLink>; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, UK.; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, UK.; Alzheimer's Research UK Oxford Drug Discovery Institute, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Tonge+PJ%22">Tonge PJ</searchLink>; Center for Advanced Study of Drug Action, Department of Chemistry, Stony Brook University, Stony Brook, NY, USA. peter.tonge@stonybrook.edu.; Department of Biomedical Genetics, University of Rochester, Rochester, NY, USA. peter.tonge@stonybrook.edu.<br /><searchLink fieldCode="AU" term="%22Robers+MB%22">Robers MB</searchLink>; Promega Corporation, Madison, WI, USA. matt.robers@promega.com.<br /><searchLink fieldCode="AU" term="%22Huber+KVM%22">Huber KVM</searchLink>; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, UK. kilian.huber@cmd.ox.ac.uk.; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, UK. kilian.huber@cmd.ox.ac.uk.
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