Microbiome-derived bile acid signatures in early life and their association with islet autoimmunity.

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Title: Microbiome-derived bile acid signatures in early life and their association with islet autoimmunity.
Authors: Lamichhane S; Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland. santosh.lamichhane@utu.fi.; Institute of Biomedicine, University of Turku, Turku, Finland. santosh.lamichhane@utu.fi.; InFLAMES Research Flagship Center, University of Turku, Turku, Finland. santosh.lamichhane@utu.fi., Dickens AM; Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland.; Department of Chemistry, University of Turku, Turku, Finland., Buchacher T; Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland.; InFLAMES Research Flagship Center, University of Turku, Turku, Finland., Lou T; Medical Research Council Laboratory of Medical Sciences (MRC LMS), Imperial College Hammersmith Campus, London, UK.; Department of Immunology and Inflammation, Imperial College London, London, UK., Charron-Lamoureux V; Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego, CA, USA., Kattelus R; Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland.; InFLAMES Research Flagship Center, University of Turku, Turku, Finland., Karmacharya P; Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland., da Silva LP; Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland., Kråkström M; Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland., Rasool O; Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland.; InFLAMES Research Flagship Center, University of Turku, Turku, Finland., Sen P; Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland., Walker C; Department of Pediatrics, University of California San Diego, La Jolla, CA, USA., Patan A; Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego, CA, USA., Gentry EC; Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego, CA, USA.; Virginia Tech, Department of Chemistry, VA, 24061, Blacksburg, USA., Zuffa S; Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego, CA, USA., Arzoomand A; Department of women's and children's health, Karolinska Institutet, Stockholm, Sweden., Lakshmikanth T; Medical Research Council Laboratory of Medical Sciences (MRC LMS), Imperial College Hammersmith Campus, London, UK.; Department of Immunology and Inflammation, Imperial College London, London, UK.; Department of women's and children's health, Karolinska Institutet, Stockholm, Sweden., Mikeš J; Department of women's and children's health, Karolinska Institutet, Stockholm, Sweden., Mebrahtu A; Medical Research Council Laboratory of Medical Sciences (MRC LMS), Imperial College Hammersmith Campus, London, UK.; Department of Immunology and Inflammation, Imperial College London, London, UK., Vatanen T; Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; Liggins Institute, University of Auckland, Auckland, New Zealand.; Institute of Biotechnology, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.; The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Faculty of Agriculture and Forestry, University of Helsinki, Helsinki, Finland., Raffatellu M; Department of Pediatrics, University of California San Diego, La Jolla, CA, USA.; Center for Microbiome Innovation, University of California, San Diego, La Jolla, CA, USA.; Chiba University-UC San Diego Center for Mucosal Immunology, Allergy, and Vaccines (CU-UCSD cMAV), La Jolla, CA, USA., Zengler K; Department of Pediatrics, University of California San Diego, La Jolla, CA, USA.; Center for Microbiome Innovation, University of California, San Diego, La Jolla, CA, USA.; Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA., Hyötyläinen T; School of Science and Technology, Örebro University, Örebro, Sweden., Xavier RJ; The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Brodin P; Medical Research Council Laboratory of Medical Sciences (MRC LMS), Imperial College Hammersmith Campus, London, UK.; Department of Immunology and Inflammation, Imperial College London, London, UK.; Department of women's and children's health, Karolinska Institutet, Stockholm, Sweden., Lahesmaa R; Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland.; Institute of Biomedicine, University of Turku, Turku, Finland.; InFLAMES Research Flagship Center, University of Turku, Turku, Finland., Dorrestein PC; Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego, CA, USA.; Center for Microbiome Innovation, University of California, San Diego, La Jolla, CA, USA., Knip M; Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland. mikael.knip@helsinki.fi.; Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland. mikael.knip@helsinki.fi.; Department of Pediatrics, Center for Child Health Research, Tampere University Hospital, Tampere, Finland. mikael.knip@helsinki.fi., Orešič M; Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland. Matej.Oresic@oru.se.; InFLAMES Research Flagship Center, University of Turku, Turku, Finland. Matej.Oresic@oru.se.; Department of Life Technologies, University of Turku, Turku, Turku, Finland. Matej.Oresic@oru.se.; School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden. Matej.Oresic@oru.se.
Source: Nature communications [Nat Commun] 2025 Dec 03; Vol. 17 (1), pp. 38. Date of Electronic Publication: 2025 Dec 03.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2041-1723
DOI:10.1038/s41467-025-66619-6