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Collaborative framework on responsible AI in LLM-driven CDSS for precision oncology leveraging real-world patient data.

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Title: Collaborative framework on responsible AI in LLM-driven CDSS for precision oncology leveraging real-world patient data.
Authors: Mathes S; TUM School of Medicine and Health, Department of Dermatology, Technical University of Munich, Munich, Germany. sonja.mathes@mri.tum.de.; Institute for History, Theory and Ethics of Medicine, University of Mainz Medical Center, Mainz, Germany. sonja.mathes@mri.tum.de., Ferber D; Else Kroener Fresenius Center for Digital Health, Technical University Dresden, Dresden, Germany.; National Center for Tumor Diseases, Heidelberg University Hospital, Heidelberg, Germany.; Department of Medical Oncology, Heidelberg University Hospital, Heidelberg, Germany., Dreyer T; TUM School of Medicine and Health, Department of Gynecology and Center for Hereditary Breast and Ovarian Cancer, Technical University of Munich, Munich, Germany.; German Cancer Consortium (DKTK), partner site Munich, a partnership between DKFZ and University Hospital of the Technical University of Munich (TUM), Munich, Germany., Borm KJ; Technical University of Munich, School of Medicine and Health, Department of Radiation Oncology, Munich, Germany.; Bavarian Center for Cancer Research (BZKF), Technical University of Munich Partner Site, Munich, Germany., Modersohn L; TUM School of Medicine and Health, Institute of Artificial Intelligence in Medicine and Healthcare, Technical University of Munich, Munich, Germany., Willem T; TUM School of Medicine and Health, Institute of History and Ethics in Medicine, Technical University of Munich, Munich, Germany.; Helmholtz Munich, Munich, Germany., Dirven R; Department of Head and Neck Surgery and Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands.; Department of Otorhinolaryngology and Head and Neck Surgery, Radboud University Medical Center, Nijmegen, the Netherlands.; Cancer Core Europe, Villejuif, France., Vibert J; Cancer Core Europe, Villejuif, France.; Drug Development Department, Gustave Roussy, DITEP, Villejuif, France., Kreutzfeldt S; Cancer Core Europe, Villejuif, France.; Division of Translational Medical Oncology, German Cancer Research Center (DKFZ), and NCT Heidelberg, Heidelberg, Germany., Perez-Lopez R; Cancer Core Europe, Villejuif, France.; Radiomics Group, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain., Prelaj A; Cancer Core Europe, Villejuif, France.; Department of Medical Oncology, AI-ON-Lab, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy., Strand F; Department of Oncology and Pathology, Karolinska Institutet, Solna, Sweden.; Medical Diagnostics Karolinska, Karolinska University Hospital, Solna, Sweden., Baird RD; Cancer Core Europe, Villejuif, France.; Cancer Research UK Cambridge Centre, Cambridge, UK., Boeker M; TUM School of Medicine and Health, Institute of Artificial Intelligence in Medicine and Healthcare, Technical University of Munich, Munich, Germany., Kather JN; Else Kroener Fresenius Center for Digital Health, Technical University Dresden, Dresden, Germany.; National Center for Tumor Diseases, Heidelberg University Hospital, Heidelberg, Germany.; Department of Medical Oncology, Heidelberg University Hospital, Heidelberg, Germany.; Cancer Core Europe, Villejuif, France.; Department of Medicine I, University Hospital Dresden, Dresden, Germany., Tschochohei M; TUM School of Medicine and Health, Institute of Artificial Intelligence in Medicine and Healthcare, Technical University of Munich, Munich, Germany.; Google Cloud, Munich, Germany., Lammert J; TUM School of Medicine and Health, Department of Gynecology and Center for Hereditary Breast and Ovarian Cancer, Technical University of Munich, Munich, Germany.; German Cancer Consortium (DKTK), partner site Munich, a partnership between DKFZ and University Hospital of the Technical University of Munich (TUM), Munich, Germany.; TUM School of Medicine and Health, Institute of Artificial Intelligence in Medicine and Healthcare, Technical University of Munich, Munich, Germany.; TUM School of Medicine and Health, Center for Personalized Medicine (ZPM), University Hospital of the Technical University of Munich (TUM), Munich, Germany.
Source: NPJ precision oncology [NPJ Precis Oncol] 2025 Dec 04; Vol. 10 (1), pp. 15. Date of Electronic Publication: 2025 Dec 04.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: England NLM ID: 101708166 Publication Model: Electronic Cited Medium: Print ISSN: 2397-768X (Print) Linking ISSN: 2397768X NLM ISO Abbreviation: NPJ Precis Oncol Subsets: PubMed not MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Mathes+S%22">Mathes S</searchLink>; TUM School of Medicine and Health, Department of Dermatology, Technical University of Munich, Munich, Germany. sonja.mathes@mri.tum.de.; Institute for History, Theory and Ethics of Medicine, University of Mainz Medical Center, Mainz, Germany. sonja.mathes@mri.tum.de.<br /><searchLink fieldCode="AU" term="%22Ferber+D%22">Ferber D</searchLink>; Else Kroener Fresenius Center for Digital Health, Technical University Dresden, Dresden, Germany.; National Center for Tumor Diseases, Heidelberg University Hospital, Heidelberg, Germany.; Department of Medical Oncology, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Dreyer+T%22">Dreyer T</searchLink>; TUM School of Medicine and Health, Department of Gynecology and Center for Hereditary Breast and Ovarian Cancer, Technical University of Munich, Munich, Germany.; German Cancer Consortium (DKTK), partner site Munich, a partnership between DKFZ and University Hospital of the Technical University of Munich (TUM), Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Borm+KJ%22">Borm KJ</searchLink>; Technical University of Munich, School of Medicine and Health, Department of Radiation Oncology, Munich, Germany.; Bavarian Center for Cancer Research (BZKF), Technical University of Munich Partner Site, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Modersohn+L%22">Modersohn L</searchLink>; TUM School of Medicine and Health, Institute of Artificial Intelligence in Medicine and Healthcare, Technical University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Willem+T%22">Willem T</searchLink>; TUM School of Medicine and Health, Institute of History and Ethics in Medicine, Technical University of Munich, Munich, Germany.; Helmholtz Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Dirven+R%22">Dirven R</searchLink>; Department of Head and Neck Surgery and Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands.; Department of Otorhinolaryngology and Head and Neck Surgery, Radboud University Medical Center, Nijmegen, the Netherlands.; Cancer Core Europe, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Vibert+J%22">Vibert J</searchLink>; Cancer Core Europe, Villejuif, France.; Drug Development Department, Gustave Roussy, DITEP, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Kreutzfeldt+S%22">Kreutzfeldt S</searchLink>; Cancer Core Europe, Villejuif, France.; Division of Translational Medical Oncology, German Cancer Research Center (DKFZ), and NCT Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Perez-Lopez+R%22">Perez-Lopez R</searchLink>; Cancer Core Europe, Villejuif, France.; Radiomics Group, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Prelaj+A%22">Prelaj A</searchLink>; Cancer Core Europe, Villejuif, France.; Department of Medical Oncology, AI-ON-Lab, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Strand+F%22">Strand F</searchLink>; Department of Oncology and Pathology, Karolinska Institutet, Solna, Sweden.; Medical Diagnostics Karolinska, Karolinska University Hospital, Solna, Sweden.<br /><searchLink fieldCode="AU" term="%22Baird+RD%22">Baird RD</searchLink>; Cancer Core Europe, Villejuif, France.; Cancer Research UK Cambridge Centre, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Boeker+M%22">Boeker M</searchLink>; TUM School of Medicine and Health, Institute of Artificial Intelligence in Medicine and Healthcare, Technical University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Kather+JN%22">Kather JN</searchLink>; Else Kroener Fresenius Center for Digital Health, Technical University Dresden, Dresden, Germany.; National Center for Tumor Diseases, Heidelberg University Hospital, Heidelberg, Germany.; Department of Medical Oncology, Heidelberg University Hospital, Heidelberg, Germany.; Cancer Core Europe, Villejuif, France.; Department of Medicine I, University Hospital Dresden, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Tschochohei+M%22">Tschochohei M</searchLink>; TUM School of Medicine and Health, Institute of Artificial Intelligence in Medicine and Healthcare, Technical University of Munich, Munich, Germany.; Google Cloud, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Lammert+J%22">Lammert J</searchLink>; TUM School of Medicine and Health, Department of Gynecology and Center for Hereditary Breast and Ovarian Cancer, Technical University of Munich, Munich, Germany.; German Cancer Consortium (DKTK), partner site Munich, a partnership between DKFZ and University Hospital of the Technical University of Munich (TUM), Munich, Germany.; TUM School of Medicine and Health, Institute of Artificial Intelligence in Medicine and Healthcare, Technical University of Munich, Munich, Germany.; TUM School of Medicine and Health, Center for Personalized Medicine (ZPM), University Hospital of the Technical University of Munich (TUM), Munich, Germany.
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