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Hepatic Effects, Potential Drug-Induced Liver Injury, and Other Liver Safety Considerations of Chimeric Antigen Receptor T-Cell (CAR-T) Therapy in the New Era of Expanding Non-oncology Indications: Literature Review and Expert Consensus.

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Title: Hepatic Effects, Potential Drug-Induced Liver Injury, and Other Liver Safety Considerations of Chimeric Antigen Receptor T-Cell (CAR-T) Therapy in the New Era of Expanding Non-oncology Indications: Literature Review and Expert Consensus.
Authors: Fettiplace A; AstraZeneca, Cambridge, UK. anna@fettiplaceconsulting.com., Regev A; Eli Lilly and Company, Indianapolis, USA., Kiazand A; AstraZeneca, Cambridge, USA., Heinzel-Pleines U; Bayer Pharmaceuticals, Leverkusen, Germany., Bahjat M; Immunology Safety, Biopharmaceuticals R&D, AstraZeneca, Cambridge, UK., Garg A; Sanofi, Patient Safety and Pharmacovigilance, Morristown, NJ, USA., Kikuchi L; Bayer, SA, São Paulo, Brazil., Li H; Global Medical Safety, Johnson & Johnson, New Brunswick, NJ, USA., Hamidi A; Amgen, Thousand Oaks, USA., Alpers DH; Department of Medicine, Washington University School of Medicine, St Louis, MO, USA., Tillmann H; Division Gastroenterology, Hepatology and Nutrition, East Carolina University, Greenville, NC, USA., Larrey D; Liver Unit, Saint Eloi Hospital, Montpellier School of Medicine, Montpellier, France., Di Bisceglie AM; Saint Louis University, St. Louis, MO, USA., Lewis JH; Georgetown University Hospital, Washington, DC, USA.
Source: Drug safety [Drug Saf] 2026 Jun; Vol. 49 (6), pp. 631-654. Date of Electronic Publication: 2025 Dec 04.
Publication Type: Consensus Statement; Journal Article; Review
Journal Info: Publisher: Adis, Springer International Country of Publication: New Zealand NLM ID: 9002928 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1179-1942 (Electronic) Linking ISSN: 01145916 NLM ISO Abbreviation: Drug Saf Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Hepatic Effects, Potential Drug-Induced Liver Injury, and Other Liver Safety Considerations of Chimeric Antigen Receptor T-Cell (CAR-T) Therapy in the New Era of Expanding Non-oncology Indications: Literature Review and Expert Consensus.
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  Data: <searchLink fieldCode="AU" term="%22Fettiplace+A%22">Fettiplace A</searchLink>; AstraZeneca, Cambridge, UK. anna@fettiplaceconsulting.com.<br /><searchLink fieldCode="AU" term="%22Regev+A%22">Regev A</searchLink>; Eli Lilly and Company, Indianapolis, USA.<br /><searchLink fieldCode="AU" term="%22Kiazand+A%22">Kiazand A</searchLink>; AstraZeneca, Cambridge, USA.<br /><searchLink fieldCode="AU" term="%22Heinzel-Pleines+U%22">Heinzel-Pleines U</searchLink>; Bayer Pharmaceuticals, Leverkusen, Germany.<br /><searchLink fieldCode="AU" term="%22Bahjat+M%22">Bahjat M</searchLink>; Immunology Safety, Biopharmaceuticals R&D, AstraZeneca, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Garg+A%22">Garg A</searchLink>; Sanofi, Patient Safety and Pharmacovigilance, Morristown, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Kikuchi+L%22">Kikuchi L</searchLink>; Bayer, SA, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Li+H%22">Li H</searchLink>; Global Medical Safety, Johnson & Johnson, New Brunswick, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Hamidi+A%22">Hamidi A</searchLink>; Amgen, Thousand Oaks, USA.<br /><searchLink fieldCode="AU" term="%22Alpers+DH%22">Alpers DH</searchLink>; Department of Medicine, Washington University School of Medicine, St Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Tillmann+H%22">Tillmann H</searchLink>; Division Gastroenterology, Hepatology and Nutrition, East Carolina University, Greenville, NC, USA.<br /><searchLink fieldCode="AU" term="%22Larrey+D%22">Larrey D</searchLink>; Liver Unit, Saint Eloi Hospital, Montpellier School of Medicine, Montpellier, France.<br /><searchLink fieldCode="AU" term="%22Di+Bisceglie+AM%22">Di Bisceglie AM</searchLink>; Saint Louis University, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Lewis+JH%22">Lewis JH</searchLink>; Georgetown University Hospital, Washington, DC, USA.
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  Data: <searchLink fieldCode="JN" term="%229002928%22">Drug safety</searchLink> [Drug Saf] 2026 Jun; Vol. 49 (6), pp. 631-654. <i>Date of Electronic Publication: </i>2025 Dec 04.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Adis%2C+Springer+International%22">Adis, Springer International </searchLink><i>Country of Publication: </i>New Zealand <i>NLM ID: </i>9002928 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1179-1942 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2201145916%22">01145916 </searchLink><i>NLM ISO Abbreviation: </i>Drug Saf <i>Subsets: </i>MEDLINE
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              Text: 2026 Jun
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