Balancing cell cycle arrest and immune activation: A synergistic window for idasanutlin and anti-PD-1 therapy in a syngeneic mouse model.

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Title: Balancing cell cycle arrest and immune activation: A synergistic window for idasanutlin and anti-PD-1 therapy in a syngeneic mouse model.
Authors: Nieznanska A; Department of Organic Chemistry, Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, Krakow 30-387, Poland., Statkiewicz M; Laboratory of Cancer Metabolism, Department of Experimental Oncology, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw 02-781, Poland., Sandowska-Markiewicz Z; Laboratory of Preclinical Research, Department of Experimental Oncology, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw 02-781, Poland., Unrug-Bielawska K; Laboratory of Preclinical Research, Department of Experimental Oncology, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw 02-781, Poland., Majewska A; Department of Organic Chemistry, Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, Krakow 30-387, Poland., Kocik-Krol J; Department of Organic Chemistry, Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, Krakow 30-387, Poland., Czepiel M; Jagiellonian University Medical College, Institute of Pediatrics, Department of Clinical Immunology, Wielicka 265, Krakow 30-663, Poland., Galuszka-Bulaga A; Jagiellonian University Medical College, Institute of Pediatrics, Department of Clinical Immunology, Wielicka 265, Krakow 30-663, Poland., Mikula M; Laboratory of Cancer Metabolism, Department of Experimental Oncology, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw 02-781, Poland., Ostrowski J; Laboratory of Cancer Metabolism, Department of Experimental Oncology, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw 02-781, Poland., Holak TA; Department of Organic Chemistry, Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, Krakow 30-387, Poland., Skalniak L; Department of Organic Chemistry, Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, Krakow 30-387, Poland. Electronic address: lukasz.skalniak@uj.edu.pl.
Source: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2025 Dec; Vol. 193, pp. 118868. Date of Electronic Publication: 2025 Dec 04.
Publication Type: Journal Article
Journal Info: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 8213295 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1950-6007 (Electronic) Linking ISSN: 07533322 NLM ISO Abbreviation: Biomed Pharmacother Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1950-6007
DOI:10.1016/j.biopha.2025.118868