Road traffic noise exposure and blood DNA methylation at birth and in childhood: An epigenome-wide meta-analysis.

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Title: Road traffic noise exposure and blood DNA methylation at birth and in childhood: An epigenome-wide meta-analysis.
Authors: Yu Z; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden., Fontes Marques I; The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands; Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands., Kebede Merid S; Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden., Burrows K; Centre for Academic Child Health, Population Health Sciences, Bristol Medical School at the University of Bristol, Bristol, UK; Population Health Science, Bristol Medical School, University of Bristol, Bristol, UK., Soares AG; Population Health Science, Bristol Medical School, University of Bristol, Bristol, UK; MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK., Pyko A; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Centre for Occupational and Environmental Medicine, Region Stockholm, Sweden., Ögren M; Occupational and Environmental Medicine, School of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden., Pershagen G; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden., Lepeule J; Université Grenoble Alpes, INSERM U1209, CNRS UMR 5309, Institut pour l'Avancée des Biosciences (IAB), Team of Environmental Epidemiology Applied to Development and Respiratory Health, 38000 Grenoble, France., Hjertager Krog N; Department of Air Quality and Noise, Division of Climate and Environmental Health, Norwegian Institute of Public Health, Oslo, Norway., Aasvang GM; Department of Air Quality and Noise, Division of Climate and Environmental Health, Norwegian Institute of Public Health, Oslo, Norway., Kusters MSW; ISGlobal, Barcelona, Spain; Universitat Pompeu Fabra, Barcelona, Spain; Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Centre, Rotterdam, the Netherlands., Foraster M; PHAGEX Research Group, Blanquerna School of Health Science, Universitat Ramon Llull (URL), Barcelona, Spain., Bustamante M; ISGlobal, Barcelona, Spain; Universitat Pompeu Fabra, Barcelona, Spain; CIBER Epidemiología y Salud Púbica, Madrid, Spain., Leskien M; Institute of Epidemiology, Helmholtz Zentrum München- German Research Center for Environmental Health, Neuherberg, Germany; Institute for Medical Information Processing, Biometry, and Epidemiology, Medical Faculty, Ludwig-Maximilians-Universität München, Munich, Germany., Thiering E; Institute of Epidemiology, Helmholtz Zentrum München- German Research Center for Environmental Health, Neuherberg, Germany; Department of Pediatrics, Dr. von Hauner Children's Hospital, LMU University Hospital, Ludwig-Maximilians-Universität München, Munich, Germany., Elhakeem A; Population Health Science, Bristol Medical School, University of Bristol, Bristol, UK; MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK., Peters A; Institute of Epidemiology, Helmholtz Zentrum München- German Research Center for Environmental Health, Neuherberg, Germany; Chair of Epidemiology, Institute for Medical Information Processing, Biometry and Epidemiology, Médical Faculty, Ludwig-Maximilians-Universit ̈ at München, Munich, Germany; Munich Heart Alliance, German Center for Cardiovascular Health (DZHK e.V., partner-site Munich), Munich, Germany., Koppelman GH; University of Groningen, University Medical Center Groningen, Beatrix Children's Hospital, Department of Pediatric Pulmonology and Pediatric Allergology, Groningen, the Netherlands; University of Groningen, University Medical Center Groningen, GRIAC Research Institute, Groningen, the Netherlands., Gehring U; Institute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands., Vonk JM; University of Groningen, University Medical Center Groningen, Beatrix Children's Hospital, Department of Pediatric Pulmonology and Pediatric Allergology, Groningen, the Netherlands; University of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, the Netherlands., Jeong A; Swiss Tropical and Public Health Institute, Allschwil, Switzerland; University of Basel, Basel, Switzerland., Imboden M; Swiss Tropical and Public Health Institute, Allschwil, Switzerland; University of Basel, Basel, Switzerland., Probst-Hensch N; Swiss Tropical and Public Health Institute, Allschwil, Switzerland; University of Basel, Basel, Switzerland., Vermeulen R; Institute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands., Nieuwenhuijsen M; ISGlobal, Barcelona, Spain; Universitat Pompeu Fabra, Barcelona, Spain; CIBER Epidemiología y Salud Púbica, Madrid, Spain., Guxens M; ISGlobal, Barcelona, Spain; Universitat Pompeu Fabra, Barcelona, Spain; Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Centre, Rotterdam, the Netherlands; CIBER Epidemiología y Salud Púbica, Madrid, Spain; ICREA, Barcelona, Spain., Standl M; Institute of Epidemiology, Helmholtz Zentrum München- German Research Center for Environmental Health, Neuherberg, Germany; German Center for Child and Adolescent Health (DZKJ), Munich, Germany; German Center for Lung Research (DZL), Munich, Germany., Jaddoe VWJ; The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands; Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands., London SJ; Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA., Melén E; Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden., Felix JF; The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands; Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands., Gruzieva O; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Centre for Occupational and Environmental Medicine, Region Stockholm, Sweden. Electronic address: olena.gruzieva@ki.se.
Source: Environment international [Environ Int] 2026 Jan; Vol. 207, pp. 109976. Date of Electronic Publication: 2025 Dec 02.
Publication Type: Journal Article; Meta-Analysis
Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 7807270 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6750 (Electronic) Linking ISSN: 01604120 NLM ISO Abbreviation: Environ Int Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1873-6750
DOI:10.1016/j.envint.2025.109976