Chinese medicine (Tiao-Chang Ke-Min granules) placebo and nocebo effects for diarrhea-predominant irritable bowel syndrome: a study protocol for a randomized controlled trial based on a balanced experimental design.

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Title: Chinese medicine (Tiao-Chang Ke-Min granules) placebo and nocebo effects for diarrhea-predominant irritable bowel syndrome: a study protocol for a randomized controlled trial based on a balanced experimental design.
Authors: Li Q; Chinese Medicine Syndrome Research Team, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.; The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, China., Zhou L; The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, China., Chen G; Evidence Based Medicine and Clinical Research Service Group, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China., Zhao X; Department of Gastroenterology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China. zhaoxiyg523@126.com., Yang X; Chinese Medicine Syndrome Research Team, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China. yangxiaobomd2021@hotmail.com.
Source: BMC complementary medicine and therapies [BMC Complement Med Ther] 2025 Dec 06; Vol. 26 (1). Date of Electronic Publication: 2025 Dec 06.
Publication Type: Journal Article; Clinical Trial Protocol
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101761232 Publication Model: Electronic Cited Medium: Internet ISSN: 2662-7671 (Electronic) Linking ISSN: 26627671 NLM ISO Abbreviation: BMC Complement Med Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2662-7671
DOI:10.1186/s12906-025-05205-1