Real-time neurofeedback, its neurotransmitter underpinnings, and therapeutic effects: study protocol for a randomized controlled trial in individuals at clinical high risk.

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Title: Real-time neurofeedback, its neurotransmitter underpinnings, and therapeutic effects: study protocol for a randomized controlled trial in individuals at clinical high risk.
Authors: Vandewouw MM; Center for Precision Psychiatry, Department of Psychiatry, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA, 02114, USA. mvandewouw@mgh.harvard.edu.; Department of Psychiatry, Harvard Medical School, Boston, MA, USA. mvandewouw@mgh.harvard.edu., Bauer CCC; Department of Psychology, Northeastern University, Boston, MA, USA., Zhang J; Center for Precision Psychiatry, Department of Psychiatry, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA, 02114, USA.; Department of Psychiatry, Harvard Medical School, Boston, MA, USA., Hammoud J; Center for Precision Psychiatry, Department of Psychiatry, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA, 02114, USA., Greene KD; Center for Precision Psychiatry, Department of Psychiatry, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA, 02114, USA.; Department of Psychology, Northeastern University, Boston, MA, USA., Hinds O; Orchard Scientific, Yucca Valley, CA, USA., Wighton P; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA., Smoller JW; Center for Precision Psychiatry, Department of Psychiatry, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA, 02114, USA.; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.; Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA., Stone WS; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.; Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA., Evins AE; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.; Center for Addiction Medicine, Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA., Lin AP; Center for Clinical Spectroscopy, Department of Radiology, Brigham and Women's Hospital, Boston, MA, USA.; Department of Radiology, Harvard Medical School, Boston, MA, USA., Niznikiewicz MA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.; Laboratory of Neuroscience, Boston Veterans Affairs Healthcare System, Boston, MA, USA., Whitfield-Gabrieli S; Center for Precision Psychiatry, Department of Psychiatry, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA, 02114, USA.; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.; Department of Psychology, Northeastern University, Boston, MA, USA.
Source: BMC psychiatry [BMC Psychiatry] 2025 Dec 06; Vol. 26 (1), pp. 30. Date of Electronic Publication: 2025 Dec 06.
Publication Type: Journal Article; Randomized Controlled Trial
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 100968559 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-244X (Electronic) Linking ISSN: 1471244X NLM ISO Abbreviation: BMC Psychiatry Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1471-244X
DOI:10.1186/s12888-025-07551-3