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Discovery and Optimization of Thieno[2,3-d]pyrimidine Inhibitors of NADH-Quinone Oxidoreductase (NuoD) as Medical Countermeasures against Francisella tularensis.

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Title: Discovery and Optimization of Thieno[2,3-d]pyrimidine Inhibitors of NADH-Quinone Oxidoreductase (NuoD) as Medical Countermeasures against Francisella tularensis.
Authors: Miller ZD; Department of Drug Development, Experimental Therapeutics Branch, Walter Reed Army Institute of Research (WRAIR), 503 Robert Grant Ave, Silver Spring, Maryland 20910, United States., Tao B; Department of Drug Development, Experimental Therapeutics Branch, Walter Reed Army Institute of Research (WRAIR), 503 Robert Grant Ave, Silver Spring, Maryland 20910, United States., Mlynek KD; Bacteriology Division, United States Army Medical Research Institute of Infectious Diseases (USAMRIID), 1425 Porter Street, Fort Detrick, Maryland 21702, United States., Xander C; Bacteriology Division, United States Army Medical Research Institute of Infectious Diseases (USAMRIID), 1425 Porter Street, Fort Detrick, Maryland 21702, United States., Martinez EE; Bacteriology Division, United States Army Medical Research Institute of Infectious Diseases (USAMRIID), 1425 Porter Street, Fort Detrick, Maryland 21702, United States., Richardson JB; Molecular Biology Division, United States Army Medical Research Institute of Infectious Diseases (USAMRIID), 1425 Porter Street, Fort Detrick, Maryland 21702, United States., Toothman RG; Bacteriology Division, United States Army Medical Research Institute of Infectious Diseases (USAMRIID), 1425 Porter Street, Fort Detrick, Maryland 21702, United States., Meinig JM; Bacteriology Division, United States Army Medical Research Institute of Infectious Diseases (USAMRIID), 1425 Porter Street, Fort Detrick, Maryland 21702, United States., Bozue JA; Bacteriology Division, United States Army Medical Research Institute of Infectious Diseases (USAMRIID), 1425 Porter Street, Fort Detrick, Maryland 21702, United States., Roncal N; Department of Drug Discovery, Experimental Therapeutics Branch, Walter Reed Army Institute of Research (WRAIR), 503 Robert Grant Ave, Silver Spring, Maryland 20910, United States., Jin X; Department of Drug Development, Experimental Therapeutics Branch, Walter Reed Army Institute of Research (WRAIR), 503 Robert Grant Ave, Silver Spring, Maryland 20910, United States., Vuong C; Department of Drug Development, Experimental Therapeutics Branch, Walter Reed Army Institute of Research (WRAIR), 503 Robert Grant Ave, Silver Spring, Maryland 20910, United States., Dennis WE; Department of Drug Development, Experimental Therapeutics Branch, Walter Reed Army Institute of Research (WRAIR), 503 Robert Grant Ave, Silver Spring, Maryland 20910, United States., Blount CA; Department of Drug Development, Experimental Therapeutics Branch, Walter Reed Army Institute of Research (WRAIR), 503 Robert Grant Ave, Silver Spring, Maryland 20910, United States., Wright HD; Department of Drug Development, Experimental Therapeutics Branch, Walter Reed Army Institute of Research (WRAIR), 503 Robert Grant Ave, Silver Spring, Maryland 20910, United States., Handlon AL; Department of Drug Development, Experimental Therapeutics Branch, Walter Reed Army Institute of Research (WRAIR), 503 Robert Grant Ave, Silver Spring, Maryland 20910, United States.
Source: ACS infectious diseases [ACS Infect Dis] 2026 Jan 09; Vol. 12 (1), pp. 287-297. Date of Electronic Publication: 2025 Dec 07.
Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, Non-U.S. Gov't
Journal Info: Publisher: ACS Publications Country of Publication: United States NLM ID: 101654580 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2373-8227 (Electronic) Linking ISSN: 23738227 NLM ISO Abbreviation: ACS Infect Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="JN" term="%22101654580%22">ACS infectious diseases</searchLink> [ACS Infect Dis] 2026 Jan 09; Vol. 12 (1), pp. 287-297. <i>Date of Electronic Publication: </i>2025 Dec 07.
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