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A comparative study to assess two doses of a novel aldose reductase inhibitor (ARI)/Antioxidant drug candidate Cemtirestat, the current ARI drug Epalrestat, and the antioxidant Stobadine on Fructose- and Streptozotocin-Induced hepatic and pancreatic stress responses in rats.

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Title: A comparative study to assess two doses of a novel aldose reductase inhibitor (ARI)/Antioxidant drug candidate Cemtirestat, the current ARI drug Epalrestat, and the antioxidant Stobadine on Fructose- and Streptozotocin-Induced hepatic and pancreatic stress responses in rats.
Authors: Dagistanli FK; Department of Medical Biology, Cerrahpaşa Medical Faculty, Istanbul University-Cerrahpasa, Istanbul, Turkey., Ceylan AF; Department of Medical Pharmacology, Faculty of Medicine, Ankara Yildirim Beyazıt University, Ankara, Turkey., Elmazoglu Z; Department of Pharmacology, Faculty of Pharmacy, Ankara Medipol University, Ankara, Turkey., Efendiyeva N; Department of Medical Biochemistry, Faculty of Medicine, Gazi University, Ankara, Turkey., Sarıbaş SG; Department of Histology and Embryology, Faculty of Medicine, Health Sciences University Gulhane, Ankara, Turkey., Pilafi BK; Medical University of Tirana, University Dental Clinic, Tiran, Albania., Stefek M; Department of Biochemical Pharmacology, Institute of Experimental Pharmacology and Toxicology, Slovak Academy of Sciences, Bratislava, Slovak Republic., Ulusu NN; Department of Biochemistry, School of Medicine, Koç University; Koç University Research Center for Translational Medicine (KUTTAM), Istanbul, Turkey., Karasu Ç; Department of Medical Pharmacology, Cellular Stress Response and Signal Transduction Research Laboratory, Faculty of Medicine, Gazi University, Ankara, Turkey.
Source: Journal of diabetes and metabolic disorders [J Diabetes Metab Disord] 2025 Dec 04; Vol. 24 (2), pp. 288. Date of Electronic Publication: 2025 Dec 04 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Springer International Publishing Country of Publication: Switzerland NLM ID: 101590741 Publication Model: eCollection Cited Medium: Print ISSN: 2251-6581 (Print) Linking ISSN: 22516581 NLM ISO Abbreviation: J Diabetes Metab Disord Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: A comparative study to assess two doses of a novel aldose reductase inhibitor (ARI)/Antioxidant drug candidate Cemtirestat, the current ARI drug Epalrestat, and the antioxidant Stobadine on Fructose- and Streptozotocin-Induced hepatic and pancreatic stress responses in rats.
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  Data: <searchLink fieldCode="AU" term="%22Dagistanli+FK%22">Dagistanli FK</searchLink>; Department of Medical Biology, Cerrahpaşa Medical Faculty, Istanbul University-Cerrahpasa, Istanbul, Turkey.<br /><searchLink fieldCode="AU" term="%22Ceylan+AF%22">Ceylan AF</searchLink>; Department of Medical Pharmacology, Faculty of Medicine, Ankara Yildirim Beyazıt University, Ankara, Turkey.<br /><searchLink fieldCode="AU" term="%22Elmazoglu+Z%22">Elmazoglu Z</searchLink>; Department of Pharmacology, Faculty of Pharmacy, Ankara Medipol University, Ankara, Turkey.<br /><searchLink fieldCode="AU" term="%22Efendiyeva+N%22">Efendiyeva N</searchLink>; Department of Medical Biochemistry, Faculty of Medicine, Gazi University, Ankara, Turkey.<br /><searchLink fieldCode="AU" term="%22Sarıbaş+SG%22">Sarıbaş SG</searchLink>; Department of Histology and Embryology, Faculty of Medicine, Health Sciences University Gulhane, Ankara, Turkey.<br /><searchLink fieldCode="AU" term="%22Pilafi+BK%22">Pilafi BK</searchLink>; Medical University of Tirana, University Dental Clinic, Tiran, Albania.<br /><searchLink fieldCode="AU" term="%22Stefek+M%22">Stefek M</searchLink>; Department of Biochemical Pharmacology, Institute of Experimental Pharmacology and Toxicology, Slovak Academy of Sciences, Bratislava, Slovak Republic.<br /><searchLink fieldCode="AU" term="%22Ulusu+NN%22">Ulusu NN</searchLink>; Department of Biochemistry, School of Medicine, Koç University; Koç University Research Center for Translational Medicine (KUTTAM), Istanbul, Turkey.<br /><searchLink fieldCode="AU" term="%22Karasu+Ç%22">Karasu Ç</searchLink>; Department of Medical Pharmacology, Cellular Stress Response and Signal Transduction Research Laboratory, Faculty of Medicine, Gazi University, Ankara, Turkey.
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  Data: <searchLink fieldCode="JN" term="%22101590741%22">Journal of diabetes and metabolic disorders</searchLink> [J Diabetes Metab Disord] 2025 Dec 04; Vol. 24 (2), pp. 288. <i>Date of Electronic Publication: </i>2025 Dec 04 (<i>Print Publication: </i>2025).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+International+Publishing%22">Springer International Publishing </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>101590741 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Print <i>ISSN: </i>2251-6581 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2222516581%22">22516581 </searchLink><i>NLM ISO Abbreviation: </i>J Diabetes Metab Disord <i>Subsets: </i>PubMed not MEDLINE
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        Value: 10.1007/s40200-025-01723-4
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        Text: English
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        StartPage: 288
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      – TitleFull: A comparative study to assess two doses of a novel aldose reductase inhibitor (ARI)/Antioxidant drug candidate Cemtirestat, the current ARI drug Epalrestat, and the antioxidant Stobadine on Fructose- and Streptozotocin-Induced hepatic and pancreatic stress responses in rats.
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            – D: 04
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              Text: 2025 Dec 04
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