Matrix-directed therapy losartan to identify the effect on the bone resorption marker carboxy-terminal crosslink of type I collagen telopeptide (CTX) in older adolescents and adults with osteogenesis imperfecta recruited from secondary care sites: the 'MOI-A' study; a randomised, phase 2/pilot, dose-escalating trial.
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| Title: | Matrix-directed therapy losartan to identify the effect on the bone resorption marker carboxy-terminal crosslink of type I collagen telopeptide (CTX) in older adolescents and adults with osteogenesis imperfecta recruited from secondary care sites: the 'MOI-A' study; a randomised, phase 2/pilot, dose-escalating trial. |
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| Authors: | Haji Sadeghi M; Hull Health Trials Unit, University of Hull, Hull, UK mahboobeh.hajisadeghi@hyms.ac.uk., Cohen J; Hull Health Trials Unit, University of Hull, Hull, UK., Williams B; Hull Health Trials Unit, University of Hull, Hull, UK., Wilkinson A; Hull Health Trials Unit, University of Hull, Hull, UK., Sumpter S; Hull Health Trials Unit, University of Hull, Hull, UK., Simms L; Hull Health Trials Unit, University of Hull, Hull, UK., Huang C; Hull Health Trials Unit, University of Hull, Hull, UK., Pugh K; Sheffield Children's NHS Foundation Trust, Sheffield, UK., Heath C; Sheffield Children's NHS Foundation Trust, Sheffield, UK., Sangiorgi L; IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy., Gurioli F; IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy., Gnoli M; IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy., Moroni A; IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy., Leopardi MP; IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy., Del Coco C; IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy., Bishop N; Sheffield Children's NHS Foundation Trust, Sheffield, UK.; The University of Sheffield, Sheffield, UK. |
| Source: | BMJ open [BMJ Open] 2025 Dec 07; Vol. 15 (12), pp. e107243. Date of Electronic Publication: 2025 Dec 07. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101552874 Publication Model: Electronic Cited Medium: Internet ISSN: 2044-6055 (Electronic) Linking ISSN: 20446055 NLM ISO Abbreviation: BMJ Open Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| ISSN: | 2044-6055 |
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| DOI: | 10.1136/bmjopen-2025-107243 |
