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Matrix-directed therapy losartan to identify the effect on the bone resorption marker carboxy-terminal crosslink of type I collagen telopeptide (CTX) in older adolescents and adults with osteogenesis imperfecta recruited from secondary care sites: the 'MOI-A' study; a randomised, phase 2/pilot, dose-escalating trial.

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Title: Matrix-directed therapy losartan to identify the effect on the bone resorption marker carboxy-terminal crosslink of type I collagen telopeptide (CTX) in older adolescents and adults with osteogenesis imperfecta recruited from secondary care sites: the 'MOI-A' study; a randomised, phase 2/pilot, dose-escalating trial.
Authors: Haji Sadeghi M; Hull Health Trials Unit, University of Hull, Hull, UK mahboobeh.hajisadeghi@hyms.ac.uk., Cohen J; Hull Health Trials Unit, University of Hull, Hull, UK., Williams B; Hull Health Trials Unit, University of Hull, Hull, UK., Wilkinson A; Hull Health Trials Unit, University of Hull, Hull, UK., Sumpter S; Hull Health Trials Unit, University of Hull, Hull, UK., Simms L; Hull Health Trials Unit, University of Hull, Hull, UK., Huang C; Hull Health Trials Unit, University of Hull, Hull, UK., Pugh K; Sheffield Children's NHS Foundation Trust, Sheffield, UK., Heath C; Sheffield Children's NHS Foundation Trust, Sheffield, UK., Sangiorgi L; IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy., Gurioli F; IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy., Gnoli M; IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy., Moroni A; IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy., Leopardi MP; IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy., Del Coco C; IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy., Bishop N; Sheffield Children's NHS Foundation Trust, Sheffield, UK.; The University of Sheffield, Sheffield, UK.
Source: BMJ open [BMJ Open] 2025 Dec 07; Vol. 15 (12), pp. e107243. Date of Electronic Publication: 2025 Dec 07.
Publication Type: Journal Article
Journal Info: Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101552874 Publication Model: Electronic Cited Medium: Internet ISSN: 2044-6055 (Electronic) Linking ISSN: 20446055 NLM ISO Abbreviation: BMJ Open Subsets: MEDLINE
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  Data: Matrix-directed therapy losartan to identify the effect on the bone resorption marker carboxy-terminal crosslink of type I collagen telopeptide (CTX) in older adolescents and adults with osteogenesis imperfecta recruited from secondary care sites: the 'MOI-A' study; a randomised, phase 2/pilot, dose-escalating trial.
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  Data: <searchLink fieldCode="AU" term="%22Haji+Sadeghi+M%22">Haji Sadeghi M</searchLink>; Hull Health Trials Unit, University of Hull, Hull, UK mahboobeh.hajisadeghi@hyms.ac.uk.<br /><searchLink fieldCode="AU" term="%22Cohen+J%22">Cohen J</searchLink>; Hull Health Trials Unit, University of Hull, Hull, UK.<br /><searchLink fieldCode="AU" term="%22Williams+B%22">Williams B</searchLink>; Hull Health Trials Unit, University of Hull, Hull, UK.<br /><searchLink fieldCode="AU" term="%22Wilkinson+A%22">Wilkinson A</searchLink>; Hull Health Trials Unit, University of Hull, Hull, UK.<br /><searchLink fieldCode="AU" term="%22Sumpter+S%22">Sumpter S</searchLink>; Hull Health Trials Unit, University of Hull, Hull, UK.<br /><searchLink fieldCode="AU" term="%22Simms+L%22">Simms L</searchLink>; Hull Health Trials Unit, University of Hull, Hull, UK.<br /><searchLink fieldCode="AU" term="%22Huang+C%22">Huang C</searchLink>; Hull Health Trials Unit, University of Hull, Hull, UK.<br /><searchLink fieldCode="AU" term="%22Pugh+K%22">Pugh K</searchLink>; Sheffield Children's NHS Foundation Trust, Sheffield, UK.<br /><searchLink fieldCode="AU" term="%22Heath+C%22">Heath C</searchLink>; Sheffield Children's NHS Foundation Trust, Sheffield, UK.<br /><searchLink fieldCode="AU" term="%22Sangiorgi+L%22">Sangiorgi L</searchLink>; IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Gurioli+F%22">Gurioli F</searchLink>; IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Gnoli+M%22">Gnoli M</searchLink>; IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Moroni+A%22">Moroni A</searchLink>; IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Leopardi+MP%22">Leopardi MP</searchLink>; IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Del+Coco+C%22">Del Coco C</searchLink>; IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Bishop+N%22">Bishop N</searchLink>; Sheffield Children's NHS Foundation Trust, Sheffield, UK.; The University of Sheffield, Sheffield, UK.
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  Data: <searchLink fieldCode="JN" term="%22101552874%22">BMJ open</searchLink> [BMJ Open] 2025 Dec 07; Vol. 15 (12), pp. e107243. <i>Date of Electronic Publication: </i>2025 Dec 07.
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