HTRA1/lncRNA HTRA1-AS1 dominates in age-related macular degeneration reticular pseudodrusen genetic risk with no complement involvement.
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| Title: | HTRA1/lncRNA HTRA1-AS1 dominates in age-related macular degeneration reticular pseudodrusen genetic risk with no complement involvement. |
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| Authors: | Farashi S; Population Health and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia., Abbott CJ; Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, VIC, Australia.; Department of Surgery (Ophthalmology), The University of Melbourne, East Melbourne, VIC, Australia., Ansell BRE; Population Health and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia., Wu Z; Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, VIC, Australia.; Department of Surgery (Ophthalmology), The University of Melbourne, East Melbourne, VIC, Australia., Altay L; Department of Ophthalmology, Faculty of Medicine, University Hospital of Cologne, University of Cologne, Cologne, Germany., Arnon E; Department of Ophthalmology, Duke University Medical Centre, Durham, NC, USA., Arnould L; Ophthalmology Department, University Hospital, Dijon, France.; Pathophysiology and Epidemiology of Cerebro-Cardiovascular Diseases, (EA 7460), Faculty of Health Sciences, Université de Bourgogne, Dijon, France., Bagdasarova Y; Department of Ophthalmology, University of Washington, Seattle, WA, USA., Balaskas K; Moorfields Eye Hospital NHS Foundation Trust, University College London Institute of Ophthalmology, London, UK., Chen FK; Department of Surgery (Ophthalmology), The University of Melbourne, East Melbourne, VIC, Australia.; Centre of Ophthalmology and Visual Science (incorporating Lions Eye Institute), The University of Western Australia, Perth, WA, Australia.; Department of Ophthalmology, Royal Perth Hospital, Perth, WA, Australia.; Royal Victorian Eye and Ear Hospital, East Melbourne, VIC, Australia., Chew E; Division of Epidemiology and Clinical Applications, National Eye Institute, National Institutes of Health, Bethesda, MD, USA., Chowers I; Department of Ophthalmology, Hadassah Medical Centre and the Hebrew University of Jerusalem, Jerusalem, Israel., Clarke S; Computational Sciences, Genentech Inc, South San Francisco, California, USA., Cukras C; Unit on Clinical Investigation of Retinal Diseases, National Eye Institute, National Institute of Health, Bethesda, MD, USA., Delcourt C; University of Bordeaux, INSERM, BPH, Bordeaux, France., Delyfer MN; University of Bordeaux, INSERM, BPH, Bordeaux, France.; Department of Ophthalmology, Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France., den Hollander AI; Department of Ophthalmology, Radboud University Medical Center, Nijmegen, the Netherlands.; AbbVie, Genomics Research Center, Cambridge, MA, USA., Fauser S; Department of Ophthalmology, Faculty of Medicine, University Hospital of Cologne, University of Cologne, Cologne, Germany.; Roche Pharmaceutical Research and Early Development, Translational Medicine Ophthalmology, Roche Innovation Center, Basel, Switzerland., Finger RP; Department of Ophthalmology, University Hospital Bonn, Bonn, Germany.; Department of Ophthalmology, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany., Gabrielle PH; Ophthalmology Department, University Hospital, Dijon, France.; Centre des Science du Goût et de l'Alimentation CNRS, INRA, Université Bourgogne Franche-Comte, Dijon, France., Han J; Population Health and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia., Hodgson LAB; Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, VIC, Australia., Hogg R; Centre for Public Health, Queen's University Belfast Faculty of Medicine Health and Life Sciences, Belfast, UK., Holz FG; Department of Ophthalmology, University Hospital Bonn, Bonn, Germany., Hoyng C; Department of Ophthalmology, Radboud University Medical Center, Nijmegen, the Netherlands., Kumar H; Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, VIC, Australia.; Department of Surgery (Ophthalmology), The University of Melbourne, East Melbourne, VIC, Australia., Lad EM; Department of Ophthalmology, Duke University Medical Centre, Durham, NC, USA., Lee A; Department of Ophthalmology, University of Washington, Seattle, WA, USA., Luhmann UFO; Roche Pharmaceutical Research and Early Development, Translational Medicine Ophthalmology, Roche Innovation Center, Basel, Switzerland., Mauschitz MM; Department of Ophthalmology, University Hospital Bonn, Bonn, Germany., McKnight AJ; Centre for Public Health, Queen's University Belfast Faculty of Medicine Health and Life Sciences, Belfast, UK., McLenachan S; Centre of Ophthalmology and Visual Science (incorporating Lions Eye Institute), The University of Western Australia, Perth, WA, Australia., Mishra A; University of Bordeaux, INSERM, BPH, Bordeaux, France., Moghul I; Moorfields Eye Hospital NHS Foundation Trust, University College London Institute of Ophthalmology, London, UK., Orozco LD; Computational Sciences, Genentech Inc, South San Francisco, California, USA., Sampson DM; Centre of Ophthalmology and Visual Science (incorporating Lions Eye Institute), The University of Western Australia, Perth, WA, Australia.; The University of Western Australia, The School of Allied Health, Optometry Division, Perth, WA, Australia., Scott LW; Population Health and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia., Sitnilska V; Department of Ophthalmology, Faculty of Medicine, University Hospital of Cologne, University of Cologne, Cologne, Germany., Song S; Department of Ophthalmology, University of Washington, Seattle, WA, USA., Stockwell A; Department of Human Genetics, Genentech Inc., South San Francisco, CA, USA., Swaroop A; Neurobiology, Neurodegeneration & Repair Laboratory, National Eye Institute, Bethesda, MD, USA., Terheyden JH; Department of Ophthalmology, University Hospital Bonn, Bonn, Germany., Tiosano L; Department of Ophthalmology, Hadassah Medical Centre and the Hebrew University of Jerusalem, Jerusalem, Israel., Tufail A; Moorfields Eye Hospital NHS Foundation Trust, University College London Institute of Ophthalmology, London, UK., Yaspan BL; Department of Human Genetics, Genentech Inc., South San Francisco, CA, USA., Pébay A; Department of Anatomy and Physiology, The University of Melbourne, Parkville, VIC, Australia.; Royal Melbourne Hospital, Department of Surgery, The University of Melbourne, Parkville, VIC, Australia., Fletcher EL; Department of Anatomy and Physiology, The University of Melbourne, Parkville, VIC, Australia., Guymer RH; Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, VIC, Australia. rh.guymer@unimelb.edu.au.; Department of Surgery (Ophthalmology), The University of Melbourne, East Melbourne, VIC, Australia. rh.guymer@unimelb.edu.au., Bahlo M; Population Health and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia. bahlo@wehi.edu.au.; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia. bahlo@wehi.edu.au. |
| Corporate Authors: | MACUSTAR consortium, NICOLA consortium, Reticular Pseudodrusen Consortium |
| Source: | Nature communications [Nat Commun] 2025 Dec 08; Vol. 16 (1), pp. 10854. Date of Electronic Publication: 2025 Dec 08. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-025-65903-9 |
