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ERBB2 signaling drives immune cell evasion and resistance against immunotherapy in small cell lung cancer.

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Title: ERBB2 signaling drives immune cell evasion and resistance against immunotherapy in small cell lung cancer.
Authors: Meder L; Chair of Experimental Medicine 1, Faculty of Medicine, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany. lydia.meder@fau.de.; Comprehensive Cancer Center Erlangen-EMN (CCC ER-EMN), Universitätsklinikum Erlangen, Erlangen, Germany. lydia.meder@fau.de., Orschel CI; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Cologne, Germany.; Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.; University of Cologne, Faculty of Medicine and University Hospital Cologne, Mildred Scheel School of Oncology, Cologne, Germany., Bouchez CL; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Cologne, Germany.; Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.; University of Cologne, Faculty of Medicine and University Hospital Cologne, Mildred Scheel School of Oncology, Cologne, Germany., Gholamipoorfard R; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Cologne, Germany.; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Translational Genomics, Cologne, Germany., Orschel CV; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Cologne, Germany.; University of Cologne, Faculty of Medicine and University Hospital Cologne, Mildred Scheel School of Oncology, Cologne, Germany., Stahl D; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Cologne, Germany.; Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.; University of Cologne, Faculty of Medicine and University Hospital Cologne, Mildred Scheel School of Oncology, Cologne, Germany., Kreer C; University of Cologne, Faculty of Medicine and University Hospital Cologne, Institute of Virology, Laboratory of Experimental Immunology, Cologne, Germany., Koker M; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Cologne, Germany.; Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany., Nill M; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Cologne, Germany.; Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany., Kocak IG; Chair of Experimental Medicine 1, Faculty of Medicine, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany., Noh KW; University of Cologne, Faculty of Medicine and University Hospital Cologne, Institute of Pathology, Cologne, Germany., Zhao X; University of Cologne, Faculty of Medicine and University Hospital Cologne, Institute of Pathology, Cologne, Germany., Ullrich L; University of Cologne, Faculty of Medicine and University Hospital Cologne, Institute of Virology, Laboratory of Experimental Immunology, Cologne, Germany., Häupl B; Department of Medicine II, Hematology/Oncology, Goethe University, Frankfurt, Germany.; German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.; Frankfurt Cancer Institute (FCI), Goethe University, Frankfurt am Main, Germany.; German Cancer Consortium (DKTK), partner site Frankfurt/Mainz, a partnership between DKFZ and UCT Frankfurt-Marburg, Germany, Frankfurt am Main, Germany., Jakob J; Department of Medicine II, Hematology/Oncology, Goethe University, Frankfurt, Germany.; German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.; Frankfurt Cancer Institute (FCI), Goethe University, Frankfurt am Main, Germany., Eich ML; University of Cologne, Faculty of Medicine and University Hospital Cologne, Institute of Pathology, Cologne, Germany.; Institute of Pathology, Charité Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humbolt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany., Florin A; University of Cologne, Faculty of Medicine and University Hospital Cologne, Institute of Pathology, Cologne, Germany., Grüll H; Core Facility Experimental and Preclinical Imaging Cologne, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Diagnostic and Interventional Radiology, Cologne, Germany., Wolf J; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Cologne, Germany.; University of Cologne, Faculty of Medicine and University Hospital Cologne, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Cologne, Germany., Beleggia F; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Cologne, Germany.; University of Cologne, Faculty of Medicine and University Hospital Cologne, Mildred Scheel School of Oncology, Cologne, Germany.; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Translational Genomics, Cologne, Germany., Büttner R; Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.; University of Cologne, Faculty of Medicine and University Hospital Cologne, Institute of Pathology, Cologne, Germany.; University of Cologne, Faculty of Medicine and University Hospital Cologne, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Cologne, Germany., Oellerich T; Department of Medicine II, Hematology/Oncology, Goethe University, Frankfurt, Germany.; German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.; Frankfurt Cancer Institute (FCI), Goethe University, Frankfurt am Main, Germany.; German Cancer Consortium (DKTK), partner site Frankfurt/Mainz, a partnership between DKFZ and UCT Frankfurt-Marburg, Germany, Frankfurt am Main, Germany., Klein F; University of Cologne, Faculty of Medicine and University Hospital Cologne, Institute of Virology, Laboratory of Experimental Immunology, Cologne, Germany., Brägelmann J; Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.; University of Cologne, Faculty of Medicine and University Hospital Cologne, Mildred Scheel School of Oncology, Cologne, Germany.; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Translational Genomics, Cologne, Germany.; Medical Clinic III for Oncology, Hematology, Immune-Oncology and Rheumatology, University Hospital of Bonn, Bonn, Germany., Reinhardt HC; Department of Hematology and Stem Cell Transplantation, West German Cancer Center, University Hospital Essen, Essen, German Cancer Consortium (DKTK), Essen, Germany., Abedpour N; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Cologne, Germany.; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Translational Genomics, Cologne, Germany.; Cancer Research Center Cologne Essen (CCCE), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany., Ullrich RT; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Cologne, Germany. roland.ullrich@uk-koeln.de.; Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany. roland.ullrich@uk-koeln.de.; University of Cologne, Faculty of Medicine and University Hospital Cologne, Mildred Scheel School of Oncology, Cologne, Germany. roland.ullrich@uk-koeln.de.; University of Cologne, Faculty of Medicine and University Hospital Cologne, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Cologne, Germany. roland.ullrich@uk-koeln.de.
Source: Nature communications [Nat Commun] 2025 Dec 09; Vol. 16 (1), pp. 10983. Date of Electronic Publication: 2025 Dec 09.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-025-66800-x