Procyanidin Suppresses Tumor Growth by Activating the B-Cell MAPK Pathway through Remodulation of the Gut Microbiota and Metabolites in Hepatocellular Carcinoma.

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Title: Procyanidin Suppresses Tumor Growth by Activating the B-Cell MAPK Pathway through Remodulation of the Gut Microbiota and Metabolites in Hepatocellular Carcinoma.
Authors: Huo R; Department of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.; Department of Clinical Laboratory, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, China., Gu CZ; Department of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, China., Liu Y; Department of Pancreatic and Gastrointestinal Surgery Division, Ningbo No.2 Hospital, Ningbo, China.; Ningbo Key Laboratory of Intestinal Microecology and Human Major Diseases, Ningbo, China., Wei ZX; Department of Hepatobiliary and Pancreatic Surgery, Qunli Branch, the First Afiliated Hospital of Harbin Medical University, Harbin, China., Liu T; Shanghai Geriatric Institute of Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China., Zhu J; Department of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, China., Ding L; Department of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, China., Liu Y; Department of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, China., Wang CY; Department of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, China., Li YN; Department of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, China., He XY; Department of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, China., Yang WJ; Department of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, China., Wang BL; Department of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.; Department of Laboratory Medicine, Shanghai Geriatric Medical Center, Shanghai, China.; Department of Laboratory Medicine, Wusong Branch, Zhongshan Hospital, Fudan University, Shanghai, China.; Cancer Center, Shanghai Zhongshan Hospital, Fudan University, Shanghai, China., Wei YW; Department of Pancreatic and Gastrointestinal Surgery Division, Ningbo No.2 Hospital, Ningbo, China.; Ningbo Key Laboratory of Intestinal Microecology and Human Major Diseases, Ningbo, China., Guo W; Department of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.; Department of Laboratory Medicine, Shanghai Geriatric Medical Center, Shanghai, China.; Department of Laboratory Medicine, Xiamen Branch, Zhongshan Hospital, Fudan University, Xiamen, China.; Department of Laboratory Medicine, Wusong Branch, Zhongshan Hospital, Fudan University, Shanghai, China.; Cancer Center, Shanghai Zhongshan Hospital, Fudan University, Shanghai, China.
Source: International journal of biological sciences [Int J Biol Sci] 2026 Jan 01; Vol. 22 (1), pp. 161-177. Date of Electronic Publication: 2026 Jan 01 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Ivyspring International Country of Publication: Australia NLM ID: 101235568 Publication Model: eCollection Cited Medium: Internet ISSN: 1449-2288 (Electronic) Linking ISSN: 14492288 NLM ISO Abbreviation: Int J Biol Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Procyanidin Suppresses Tumor Growth by Activating the B-Cell MAPK Pathway through Remodulation of the Gut Microbiota and Metabolites in Hepatocellular Carcinoma.
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  Data: <searchLink fieldCode="AU" term="%22Huo+R%22">Huo R</searchLink>; Department of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.; Department of Clinical Laboratory, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, China.<br /><searchLink fieldCode="AU" term="%22Gu+CZ%22">Gu CZ</searchLink>; Department of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Liu+Y%22">Liu Y</searchLink>; Department of Pancreatic and Gastrointestinal Surgery Division, Ningbo No.2 Hospital, Ningbo, China.; Ningbo Key Laboratory of Intestinal Microecology and Human Major Diseases, Ningbo, China.<br /><searchLink fieldCode="AU" term="%22Wei+ZX%22">Wei ZX</searchLink>; Department of Hepatobiliary and Pancreatic Surgery, Qunli Branch, the First Afiliated Hospital of Harbin Medical University, Harbin, China.<br /><searchLink fieldCode="AU" term="%22Liu+T%22">Liu T</searchLink>; Shanghai Geriatric Institute of Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Zhu+J%22">Zhu J</searchLink>; Department of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Ding+L%22">Ding L</searchLink>; Department of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Liu+Y%22">Liu Y</searchLink>; Department of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Wang+CY%22">Wang CY</searchLink>; Department of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Li+YN%22">Li YN</searchLink>; Department of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22He+XY%22">He XY</searchLink>; Department of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Yang+WJ%22">Yang WJ</searchLink>; Department of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Wang+BL%22">Wang BL</searchLink>; Department of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.; Department of Laboratory Medicine, Shanghai Geriatric Medical Center, Shanghai, China.; Department of Laboratory Medicine, Wusong Branch, Zhongshan Hospital, Fudan University, Shanghai, China.; Cancer Center, Shanghai Zhongshan Hospital, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Wei+YW%22">Wei YW</searchLink>; Department of Pancreatic and Gastrointestinal Surgery Division, Ningbo No.2 Hospital, Ningbo, China.; Ningbo Key Laboratory of Intestinal Microecology and Human Major Diseases, Ningbo, China.<br /><searchLink fieldCode="AU" term="%22Guo+W%22">Guo W</searchLink>; Department of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.; Department of Laboratory Medicine, Shanghai Geriatric Medical Center, Shanghai, China.; Department of Laboratory Medicine, Xiamen Branch, Zhongshan Hospital, Fudan University, Xiamen, China.; Department of Laboratory Medicine, Wusong Branch, Zhongshan Hospital, Fudan University, Shanghai, China.; Cancer Center, Shanghai Zhongshan Hospital, Fudan University, Shanghai, China.
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  Data: <searchLink fieldCode="JN" term="%22101235568%22">International journal of biological sciences</searchLink> [Int J Biol Sci] 2026 Jan 01; Vol. 22 (1), pp. 161-177. <i>Date of Electronic Publication: </i>2026 Jan 01 (<i>Print Publication: </i>2026).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Ivyspring+International%22">Ivyspring International </searchLink><i>Country of Publication: </i>Australia <i>NLM ID: </i>101235568 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>1449-2288 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214492288%22">14492288 </searchLink><i>NLM ISO Abbreviation: </i>Int J Biol Sci <i>Subsets: </i>MEDLINE
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        Value: 10.7150/ijbs.113217
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        Text: English
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      – TitleFull: Procyanidin Suppresses Tumor Growth by Activating the B-Cell MAPK Pathway through Remodulation of the Gut Microbiota and Metabolites in Hepatocellular Carcinoma.
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              Text: 2026 Jan 01
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