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Metformin alleviates diastolic dysfunction in mice with experimental diabetic cardiomyopathy.

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Title: Metformin alleviates diastolic dysfunction in mice with experimental diabetic cardiomyopathy.
Authors: Chan JSF; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, 2-35 Medical Sciences Building, Edmonton, Alberta, T6G 2H1, Canada.; Alberta Diabetes Institute, University of Alberta, 112 St NW, Edmonton, Alberta, T6G 2R3, Canada.; Cardiovascular Research Institute, University of Alberta, Edmonton, Alberta, T6G 1C9, Canada., Tabatabaei Dakhili SA; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, 2-35 Medical Sciences Building, Edmonton, Alberta, T6G 2H1, Canada.; Alberta Diabetes Institute, University of Alberta, 112 St NW, Edmonton, Alberta, T6G 2R3, Canada.; Cardiovascular Research Institute, University of Alberta, Edmonton, Alberta, T6G 1C9, Canada., Wu NR; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, 2-35 Medical Sciences Building, Edmonton, Alberta, T6G 2H1, Canada.; Alberta Diabetes Institute, University of Alberta, 112 St NW, Edmonton, Alberta, T6G 2R3, Canada.; Cardiovascular Research Institute, University of Alberta, Edmonton, Alberta, T6G 1C9, Canada., Stenlund MJ; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, 2-35 Medical Sciences Building, Edmonton, Alberta, T6G 2H1, Canada.; Alberta Diabetes Institute, University of Alberta, 112 St NW, Edmonton, Alberta, T6G 2R3, Canada.; Cardiovascular Research Institute, University of Alberta, Edmonton, Alberta, T6G 1C9, Canada., King AN; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, 2-35 Medical Sciences Building, Edmonton, Alberta, T6G 2H1, Canada.; Alberta Diabetes Institute, University of Alberta, 112 St NW, Edmonton, Alberta, T6G 2R3, Canada.; Cardiovascular Research Institute, University of Alberta, Edmonton, Alberta, T6G 1C9, Canada., Dong L; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, 2-35 Medical Sciences Building, Edmonton, Alberta, T6G 2H1, Canada.; Alberta Diabetes Institute, University of Alberta, 112 St NW, Edmonton, Alberta, T6G 2R3, Canada.; Cardiovascular Research Institute, University of Alberta, Edmonton, Alberta, T6G 1C9, Canada.; School of Pharmacy, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai, 201203, China., Mangra-Bala IA; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, 2-35 Medical Sciences Building, Edmonton, Alberta, T6G 2H1, Canada.; Alberta Diabetes Institute, University of Alberta, 112 St NW, Edmonton, Alberta, T6G 2R3, Canada.; Cardiovascular Research Institute, University of Alberta, Edmonton, Alberta, T6G 1C9, Canada., Shafaati T; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, 2-35 Medical Sciences Building, Edmonton, Alberta, T6G 2H1, Canada.; Alberta Diabetes Institute, University of Alberta, 112 St NW, Edmonton, Alberta, T6G 2R3, Canada.; Cardiovascular Research Institute, University of Alberta, Edmonton, Alberta, T6G 1C9, Canada., Ferrari SR; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, 2-35 Medical Sciences Building, Edmonton, Alberta, T6G 2H1, Canada.; Alberta Diabetes Institute, University of Alberta, 112 St NW, Edmonton, Alberta, T6G 2R3, Canada.; Cardiovascular Research Institute, University of Alberta, Edmonton, Alberta, T6G 1C9, Canada., Greenwell AA; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, 2-35 Medical Sciences Building, Edmonton, Alberta, T6G 2H1, Canada.; Alberta Diabetes Institute, University of Alberta, 112 St NW, Edmonton, Alberta, T6G 2R3, Canada.; Cardiovascular Research Institute, University of Alberta, Edmonton, Alberta, T6G 1C9, Canada.; Temerty Faculty of Medicine, University of Toronto, 1 King's College Cir, Toronto, Ontario, M5S 1A8, Canada., Yang K; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, 2-35 Medical Sciences Building, Edmonton, Alberta, T6G 2H1, Canada.; Alberta Diabetes Institute, University of Alberta, 112 St NW, Edmonton, Alberta, T6G 2R3, Canada.; Cardiovascular Research Institute, University of Alberta, Edmonton, Alberta, T6G 1C9, Canada., Saed CT; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, 2-35 Medical Sciences Building, Edmonton, Alberta, T6G 2H1, Canada.; Alberta Diabetes Institute, University of Alberta, 112 St NW, Edmonton, Alberta, T6G 2R3, Canada.; Cardiovascular Research Institute, University of Alberta, Edmonton, Alberta, T6G 1C9, Canada.; Centre for Metabolism, Obesity, Diabetes Research, McMaster University, 1280 Main St W, Hamilton, Ontario, L8S 4K1, Canada., Eaton F; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, 2-35 Medical Sciences Building, Edmonton, Alberta, T6G 2H1, Canada.; Alberta Diabetes Institute, University of Alberta, 112 St NW, Edmonton, Alberta, T6G 2R3, Canada.; Cardiovascular Research Institute, University of Alberta, Edmonton, Alberta, T6G 1C9, Canada., Gopal K; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, 2-35 Medical Sciences Building, Edmonton, Alberta, T6G 2H1, Canada.; Alberta Diabetes Institute, University of Alberta, 112 St NW, Edmonton, Alberta, T6G 2R3, Canada.; Cardiovascular Research Institute, University of Alberta, Edmonton, Alberta, T6G 1C9, Canada., Steinberg GR; Centre for Metabolism, Obesity, Diabetes Research, McMaster University, 1280 Main St W, Hamilton, Ontario, L8S 4K1, Canada.; Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, 1200 Main St W, Hamilton, Ontario, L8N 3Z5, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, 1280 Main St W, Hamilton, Ontario, L8S 4K1, Canada., Dyck JRB; Alberta Diabetes Institute, University of Alberta, 112 St NW, Edmonton, Alberta, T6G 2R3, Canada.; Cardiovascular Research Institute, University of Alberta, Edmonton, Alberta, T6G 1C9, Canada.; Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, 11405-87 Ave NW, Edmonton, Alberta, T6G 1C9, Canada., Ussher JR; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, 2-35 Medical Sciences Building, Edmonton, Alberta, T6G 2H1, Canada.; Alberta Diabetes Institute, University of Alberta, 112 St NW, Edmonton, Alberta, T6G 2R3, Canada.; Cardiovascular Research Institute, University of Alberta, Edmonton, Alberta, T6G 1C9, Canada.
Source: Journal of molecular and cellular cardiology plus [J Mol Cell Cardiol Plus] 2025 Nov 14; Vol. 14, pp. 100825. Date of Electronic Publication: 2025 Nov 14 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Ltd Country of Publication: England NLM ID: 9918470779706676 Publication Model: eCollection Cited Medium: Internet ISSN: 2772-9761 (Electronic) Linking ISSN: 27729761 NLM ISO Abbreviation: J Mol Cell Cardiol Plus Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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IllustrationInfo
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  Data: Metformin alleviates diastolic dysfunction in mice with experimental diabetic cardiomyopathy.
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  Data: <searchLink fieldCode="AU" term="%22Chan+JSF%22">Chan JSF</searchLink>; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, 2-35 Medical Sciences Building, Edmonton, Alberta, T6G 2H1, Canada.; Alberta Diabetes Institute, University of Alberta, 112 St NW, Edmonton, Alberta, T6G 2R3, Canada.; Cardiovascular Research Institute, University of Alberta, Edmonton, Alberta, T6G 1C9, Canada.<br /><searchLink fieldCode="AU" term="%22Tabatabaei+Dakhili+SA%22">Tabatabaei Dakhili SA</searchLink>; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, 2-35 Medical Sciences Building, Edmonton, Alberta, T6G 2H1, Canada.; Alberta Diabetes Institute, University of Alberta, 112 St NW, Edmonton, Alberta, T6G 2R3, Canada.; Cardiovascular Research Institute, University of Alberta, Edmonton, Alberta, T6G 1C9, Canada.<br /><searchLink fieldCode="AU" term="%22Wu+NR%22">Wu NR</searchLink>; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, 2-35 Medical Sciences Building, Edmonton, Alberta, T6G 2H1, Canada.; Alberta Diabetes Institute, University of Alberta, 112 St NW, Edmonton, Alberta, T6G 2R3, Canada.; Cardiovascular Research Institute, University of Alberta, Edmonton, Alberta, T6G 1C9, Canada.<br /><searchLink fieldCode="AU" term="%22Stenlund+MJ%22">Stenlund MJ</searchLink>; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, 2-35 Medical Sciences Building, Edmonton, Alberta, T6G 2H1, Canada.; Alberta Diabetes Institute, University of Alberta, 112 St NW, Edmonton, Alberta, T6G 2R3, Canada.; Cardiovascular Research Institute, University of Alberta, Edmonton, Alberta, T6G 1C9, Canada.<br /><searchLink fieldCode="AU" term="%22King+AN%22">King AN</searchLink>; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, 2-35 Medical Sciences Building, Edmonton, Alberta, T6G 2H1, Canada.; Alberta Diabetes Institute, University of Alberta, 112 St NW, Edmonton, Alberta, T6G 2R3, Canada.; Cardiovascular Research Institute, University of Alberta, Edmonton, Alberta, T6G 1C9, Canada.<br /><searchLink fieldCode="AU" term="%22Dong+L%22">Dong L</searchLink>; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, 2-35 Medical Sciences Building, Edmonton, Alberta, T6G 2H1, Canada.; Alberta Diabetes Institute, University of Alberta, 112 St NW, Edmonton, Alberta, T6G 2R3, Canada.; Cardiovascular Research Institute, University of Alberta, Edmonton, Alberta, T6G 1C9, Canada.; School of Pharmacy, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai, 201203, China.<br /><searchLink fieldCode="AU" term="%22Mangra-Bala+IA%22">Mangra-Bala IA</searchLink>; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, 2-35 Medical Sciences Building, Edmonton, Alberta, T6G 2H1, Canada.; Alberta Diabetes Institute, University of Alberta, 112 St NW, Edmonton, Alberta, T6G 2R3, Canada.; Cardiovascular Research Institute, University of Alberta, Edmonton, Alberta, T6G 1C9, Canada.<br /><searchLink fieldCode="AU" term="%22Shafaati+T%22">Shafaati T</searchLink>; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, 2-35 Medical Sciences Building, Edmonton, Alberta, T6G 2H1, Canada.; Alberta Diabetes Institute, University of Alberta, 112 St NW, Edmonton, Alberta, T6G 2R3, Canada.; Cardiovascular Research Institute, University of Alberta, Edmonton, Alberta, T6G 1C9, Canada.<br /><searchLink fieldCode="AU" term="%22Ferrari+SR%22">Ferrari SR</searchLink>; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, 2-35 Medical Sciences Building, Edmonton, Alberta, T6G 2H1, Canada.; Alberta Diabetes Institute, University of Alberta, 112 St NW, Edmonton, Alberta, T6G 2R3, Canada.; Cardiovascular Research Institute, University of Alberta, Edmonton, Alberta, T6G 1C9, Canada.<br /><searchLink fieldCode="AU" term="%22Greenwell+AA%22">Greenwell AA</searchLink>; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, 2-35 Medical Sciences Building, Edmonton, Alberta, T6G 2H1, Canada.; Alberta Diabetes Institute, University of Alberta, 112 St NW, Edmonton, Alberta, T6G 2R3, Canada.; Cardiovascular Research Institute, University of Alberta, Edmonton, Alberta, T6G 1C9, Canada.; Temerty Faculty of Medicine, University of Toronto, 1 King's College Cir, Toronto, Ontario, M5S 1A8, Canada.<br /><searchLink fieldCode="AU" term="%22Yang+K%22">Yang K</searchLink>; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, 2-35 Medical Sciences Building, Edmonton, Alberta, T6G 2H1, Canada.; Alberta Diabetes Institute, University of Alberta, 112 St NW, Edmonton, Alberta, T6G 2R3, Canada.; Cardiovascular Research Institute, University of Alberta, Edmonton, Alberta, T6G 1C9, Canada.<br /><searchLink fieldCode="AU" term="%22Saed+CT%22">Saed CT</searchLink>; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, 2-35 Medical Sciences Building, Edmonton, Alberta, T6G 2H1, Canada.; Alberta Diabetes Institute, University of Alberta, 112 St NW, Edmonton, Alberta, T6G 2R3, Canada.; Cardiovascular Research Institute, University of Alberta, Edmonton, Alberta, T6G 1C9, Canada.; Centre for Metabolism, Obesity, Diabetes Research, McMaster University, 1280 Main St W, Hamilton, Ontario, L8S 4K1, Canada.<br /><searchLink fieldCode="AU" term="%22Eaton+F%22">Eaton F</searchLink>; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, 2-35 Medical Sciences Building, Edmonton, Alberta, T6G 2H1, Canada.; Alberta Diabetes Institute, University of Alberta, 112 St NW, Edmonton, Alberta, T6G 2R3, Canada.; Cardiovascular Research Institute, University of Alberta, Edmonton, Alberta, T6G 1C9, Canada.<br /><searchLink fieldCode="AU" term="%22Gopal+K%22">Gopal K</searchLink>; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, 2-35 Medical Sciences Building, Edmonton, Alberta, T6G 2H1, Canada.; Alberta Diabetes Institute, University of Alberta, 112 St NW, Edmonton, Alberta, T6G 2R3, Canada.; Cardiovascular Research Institute, University of Alberta, Edmonton, Alberta, T6G 1C9, Canada.<br /><searchLink fieldCode="AU" term="%22Steinberg+GR%22">Steinberg GR</searchLink>; Centre for Metabolism, Obesity, Diabetes Research, McMaster University, 1280 Main St W, Hamilton, Ontario, L8S 4K1, Canada.; Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, 1200 Main St W, Hamilton, Ontario, L8N 3Z5, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, 1280 Main St W, Hamilton, Ontario, L8S 4K1, Canada.<br /><searchLink fieldCode="AU" term="%22Dyck+JRB%22">Dyck JRB</searchLink>; Alberta Diabetes Institute, University of Alberta, 112 St NW, Edmonton, Alberta, T6G 2R3, Canada.; Cardiovascular Research Institute, University of Alberta, Edmonton, Alberta, T6G 1C9, Canada.; Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, 11405-87 Ave NW, Edmonton, Alberta, T6G 1C9, Canada.<br /><searchLink fieldCode="AU" term="%22Ussher+JR%22">Ussher JR</searchLink>; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, 2-35 Medical Sciences Building, Edmonton, Alberta, T6G 2H1, Canada.; Alberta Diabetes Institute, University of Alberta, 112 St NW, Edmonton, Alberta, T6G 2R3, Canada.; Cardiovascular Research Institute, University of Alberta, Edmonton, Alberta, T6G 1C9, Canada.
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  Data: <searchLink fieldCode="JN" term="%229918470779706676%22">Journal of molecular and cellular cardiology plus</searchLink> [J Mol Cell Cardiol Plus] 2025 Nov 14; Vol. 14, pp. 100825. <i>Date of Electronic Publication: </i>2025 Nov 14 (<i>Print Publication: </i>2025).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Ltd%22">Elsevier Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9918470779706676 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>2772-9761 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2227729761%22">27729761 </searchLink><i>NLM ISO Abbreviation: </i>J Mol Cell Cardiol Plus <i>Subsets: </i>PubMed not MEDLINE
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