CoREST complex inhibition alters RNA splicing to promote neoantigen expression and enhance tumor immunity.

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Title: CoREST complex inhibition alters RNA splicing to promote neoantigen expression and enhance tumor immunity.
Authors: Fisher RJ; Department of Dermatology, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts, USA., Park K; Department of Dermatology, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts, USA., Lee K; Division of Genetics, Departments of Medicine and Biological Chemistry and Molecular Pharmacology, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts, USA., Pinjusic K; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA., Vanasse A; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA., Ennis CS; Cancer Center, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts, USA., Farokh P; Center for Cancer Immunology, Krantz Family Center for Cancer Research, and.; Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA., Ficaro SB; Department of Cancer Biology, Center for Emergent Drug Targets, and Blais Proteomics Center, Dana-Farber Cancer Institute, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA., Marto JA; Department of Cancer Biology, Center for Emergent Drug Targets, and Blais Proteomics Center, Dana-Farber Cancer Institute, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA., Jiang H; Division of Genetics, Departments of Medicine and Biological Chemistry and Molecular Pharmacology, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts, USA., Nam E; Division of Genetics, Departments of Medicine and Biological Chemistry and Molecular Pharmacology, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts, USA., Stransky S; Department of Biochemistry, Albert Einstein College of Medicine, The Bronx, New York, USA., Duke-Cohan J; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA., Akinci MA; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA., Geethadevi A; Division of Pediatric Oncology, Johns Hopkins University School of Medicine and Johns Hopkins Hospital, Bloomberg Children's Center, Baltimore, Maryland, USA., Raabe E; Division of Pediatric Oncology, Johns Hopkins University School of Medicine and Johns Hopkins Hospital, Bloomberg Children's Center, Baltimore, Maryland, USA., Fiszbein A; Department of Biology, Boston University, Boston, Massachusetts, USA., Demehri S; Center for Cancer Immunology, Krantz Family Center for Cancer Research, and.; Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA., Sidoli S; Department of Biochemistry, Albert Einstein College of Medicine, The Bronx, New York, USA., Hicks CW; Department of Pharmacology, Physiology & Biophysics, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts, USA., Keskin DB; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; Translational Immunogenomics Laboratory, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Department of Computer Science, Metropolitan College, Boston University, Boston, Massachusetts, USA.; Section for Bioinformatics, Department of Health Technology, Technical University of Denmark, Lyngby, Denmark., Wu CJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA., Cole PA; Division of Genetics, Departments of Medicine and Biological Chemistry and Molecular Pharmacology, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts, USA., Alani RM; Department of Dermatology, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts, USA.
Source: JCI insight [JCI Insight] 2025 Dec 09; Vol. 11 (2). Date of Electronic Publication: 2025 Dec 09 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model: eCollection Cited Medium: Internet ISSN: 2379-3708 (Electronic) Linking ISSN: 23793708 NLM ISO Abbreviation: JCI Insight Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2379-3708
DOI:10.1172/jci.insight.190287