Geminin inhibits DNA replication licensing by sterically blocking CDT1-MCM2 interactions.
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| Title: | Geminin inhibits DNA replication licensing by sterically blocking CDT1-MCM2 interactions. |
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| Authors: | Tomkins J; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.; MRC Laboratory of Medical Sciences (LMS), London, UK.; Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, London, UK., Edwardes LV; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.; MRC Laboratory of Medical Sciences (LMS), London, UK., Faull SV; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.; MRC Laboratory of Medical Sciences (LMS), London, UK., Peach M; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.; MRC Laboratory of Medical Sciences (LMS), London, UK., Gillespie PJ; Division of Molecular, Cell and Developmental Biology, School of Life Sciences, University of Dundee, Dundee, UK.; School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich, UK., Leber V; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.; MRC Laboratory of Medical Sciences (LMS), London, UK., Schmidt A; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.; MRC Laboratory of Medical Sciences (LMS), London, UK., Bounoua H; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.; MRC Laboratory of Medical Sciences (LMS), London, UK., Sim N; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.; MRC Laboratory of Medical Sciences (LMS), London, UK., Camarillo R; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.; MRC Laboratory of Medical Sciences (LMS), London, UK., Blow JJ; Division of Molecular, Cell and Developmental Biology, School of Life Sciences, University of Dundee, Dundee, UK.; School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich, UK., Barr AR; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK. a.barr@lms.mrc.ac.uk.; MRC Laboratory of Medical Sciences (LMS), London, UK. a.barr@lms.mrc.ac.uk., Barnard A; Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, London, UK. a.barnard@imperial.ac.uk., Speck C; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK. chris.speck@imperial.ac.uk.; MRC Laboratory of Medical Sciences (LMS), London, UK. chris.speck@imperial.ac.uk. |
| Source: | Nature communications [Nat Commun] 2025 Dec 09; Vol. 16 (1), pp. 11040. Date of Electronic Publication: 2025 Dec 09. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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