Prime editing of the β1 adrenoceptor in the brain restores physiological REM sleep in a mouse model of Alzheimer's disease.
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| Title: | Prime editing of the β |
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| Authors: | Böck D; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland. desiree.boeck@hest.ethz.ch.; Neuroscience Center Zurich (ZNZ), University of Zurich and ETH Zurich, Zurich, Switzerland. desiree.boeck@hest.ethz.ch.; Laboratory of Molecular and Behavioral Neuroscience, Institute for Neuroscience, Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland. desiree.boeck@hest.ethz.ch., Tidecks L; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland., Wilhelm M; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.; Neuroscience Center Zurich (ZNZ), University of Zurich and ETH Zurich, Zurich, Switzerland.; Laboratory of Molecular and Behavioral Neuroscience, Institute for Neuroscience, Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland., ElGrawani W; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.; Neuroscience Center Zurich (ZNZ), University of Zurich and ETH Zurich, Zurich, Switzerland., Duss S; Neuroscience Center Zurich (ZNZ), University of Zurich and ETH Zurich, Zurich, Switzerland.; Laboratory of Molecular and Behavioral Neuroscience, Institute for Neuroscience, Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland., Trevisan C; Institute of Neuropathology, University of Zurich, Zurich, Switzerland., Vena D; Institute of Neuropathology, University of Zurich, Zurich, Switzerland., Reuss AM; Neuroscience Center Zurich (ZNZ), University of Zurich and ETH Zurich, Zurich, Switzerland.; Institute of Neuropathology, University of Zurich, Zurich, Switzerland., Kissling L; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland., Ranucci M; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland., Privitera M; Neuroscience Center Zurich (ZNZ), University of Zurich and ETH Zurich, Zurich, Switzerland.; Laboratory of Molecular and Behavioral Neuroscience, Institute for Neuroscience, Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland., Polzer LK; Institute of Neuropathology, University of Zurich, Zurich, Switzerland.; Institute of Chemistry and Biochemistry, Free University of Berlin, Berlin, Germany., Economides AE; Institute of Neuropathology, University of Zurich, Zurich, Switzerland., Ioannidi EI; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland., Mendes R; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland., Weber Y; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland., Leonardi J; Neuroscience Center Zurich (ZNZ), University of Zurich and ETH Zurich, Zurich, Switzerland.; Laboratory of Molecular and Behavioral Neuroscience, Institute for Neuroscience, Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland., Mumenthaler J; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland., Villiger E; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland., Goutagny R; University of Strasbourg, CNRS, LNCA UMR 7364, Strasbourg, France., Mathis C; University of Strasbourg, CNRS, LNCA UMR 7364, Strasbourg, France., Schmidheini L; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland., Rothgangl T; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland., Janjuha S; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland., Patriarchi T; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.; Neuroscience Center Zurich (ZNZ), University of Zurich and ETH Zurich, Zurich, Switzerland., Bohacek J; Neuroscience Center Zurich (ZNZ), University of Zurich and ETH Zurich, Zurich, Switzerland.; Laboratory of Molecular and Behavioral Neuroscience, Institute for Neuroscience, Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland., Sych Y; Institute of Cellular and Integrative Neuroscience, CNRS UPR3212, University of Strasbourg, Strasbourg, France., Aguzzi A; Neuroscience Center Zurich (ZNZ), University of Zurich and ETH Zurich, Zurich, Switzerland.; Institute of Neuropathology, University of Zurich, Zurich, Switzerland., Winterer J; Laboratory of Systems Neuroscience, Institute for Neuroscience, Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland., Kompotis K; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland., Schwank G; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland. schwank@pharma.uzh.ch. |
| Source: | Nature communications [Nat Commun] 2025 Dec 09; Vol. 16 (1), pp. 10973. Date of Electronic Publication: 2025 Dec 09. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-025-65964-w |
