Chemically modified CRISPR-Cas9 enables targeting of individual G-quadruplex and i-motif structures, revealing ligand-dependent transcriptional perturbation.
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| Title: | Chemically modified CRISPR-Cas9 enables targeting of individual G-quadruplex and i-motif structures, revealing ligand-dependent transcriptional perturbation. |
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| Authors: | Nuccio SP; Imperial College London, Department of Chemistry, Molecular Sciences Research Hub, 82 Wood Lane, London, UK.; Imperial College London, Institute of Chemical Biology, Molecular Sciences Research Hub, 82 Wood Lane, London, UK., Cadoni E; Imperial College London, Department of Chemistry, Molecular Sciences Research Hub, 82 Wood Lane, London, UK.; Department of Organic and Macromolecular Chemistry - Organic and Biomimetic Chemistry Research Group (OBCR), Faculty of Sciences, Campus Sterre, Krijgslaan 281, Building S4, Gent, Belgium., Nikoloudaki R; Imperial College London, Department of Chemistry, Molecular Sciences Research Hub, 82 Wood Lane, London, UK., Galli S; Imperial College London, Department of Chemistry, Molecular Sciences Research Hub, 82 Wood Lane, London, UK., Ler AJ; Imperial College London, Department of Chemistry, Molecular Sciences Research Hub, 82 Wood Lane, London, UK., Sanchez-Cabanillas C; Imperial College London, Department of Chemistry, Molecular Sciences Research Hub, 82 Wood Lane, London, UK.; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, 123 Old Brompton Road, London, UK., Maher TE; Imperial College London, Department of Chemistry, Molecular Sciences Research Hub, 82 Wood Lane, London, UK.; Imperial College London, Institute of Chemical Biology, Molecular Sciences Research Hub, 82 Wood Lane, London, UK., Fan E; Imperial College London, Department of Chemistry, Molecular Sciences Research Hub, 82 Wood Lane, London, UK., Guneri D; UCL School of Pharmacy, 29-39 Brunswick Square, London, UK., Flint G; Imperial College London, Department of Chemistry, Molecular Sciences Research Hub, 82 Wood Lane, London, UK.; Imperial College London, Institute of Chemical Biology, Molecular Sciences Research Hub, 82 Wood Lane, London, UK., Zhu M; Imperial College London, Department of Chemistry, Molecular Sciences Research Hub, 82 Wood Lane, London, UK., Liu LS; Imperial College London, Department of Chemistry, Molecular Sciences Research Hub, 82 Wood Lane, London, UK., Fullenkamp CR; Chemical Biology Laboratory, National Cancer Institute, Frederick, MD, USA., Waller Z; UCL School of Pharmacy, 29-39 Brunswick Square, London, UK., Magnani L; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, 123 Old Brompton Road, London, UK.; Department of Oncology and Haemato-Oncology, Università degli Studi di Milano, Milan, Italy., Schneekloth JS Jr; Chemical Biology Laboratory, National Cancer Institute, Frederick, MD, USA., Di Antonio M; Imperial College London, Department of Chemistry, Molecular Sciences Research Hub, 82 Wood Lane, London, UK. m.di-antonio@imperial.ac.uk.; Imperial College London, Institute of Chemical Biology, Molecular Sciences Research Hub, 82 Wood Lane, London, UK. m.di-antonio@imperial.ac.uk.; The Francis Crick Institute, 1 Midland Road, London, UK. m.di-antonio@imperial.ac.uk. |
| Source: | Nature communications [Nat Commun] 2025 Dec 09; Vol. 17 (1), pp. 385. Date of Electronic Publication: 2025 Dec 09. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41366211 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Chemically modified CRISPR-Cas9 enables targeting of individual G-quadruplex and i-motif structures, revealing ligand-dependent transcriptional perturbation. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Nuccio+SP%22">Nuccio SP</searchLink>; Imperial College London, Department of Chemistry, Molecular Sciences Research Hub, 82 Wood Lane, London, UK.; Imperial College London, Institute of Chemical Biology, Molecular Sciences Research Hub, 82 Wood Lane, London, UK.<br /><searchLink fieldCode="AU" term="%22Cadoni+E%22">Cadoni E</searchLink>; Imperial College London, Department of Chemistry, Molecular Sciences Research Hub, 82 Wood Lane, London, UK.; Department of Organic and Macromolecular Chemistry - Organic and Biomimetic Chemistry Research Group (OBCR), Faculty of Sciences, Campus Sterre, Krijgslaan 281, Building S4, Gent, Belgium.<br /><searchLink fieldCode="AU" term="%22Nikoloudaki+R%22">Nikoloudaki R</searchLink>; Imperial College London, Department of Chemistry, Molecular Sciences Research Hub, 82 Wood Lane, London, UK.<br /><searchLink fieldCode="AU" term="%22Galli+S%22">Galli S</searchLink>; Imperial College London, Department of Chemistry, Molecular Sciences Research Hub, 82 Wood Lane, London, UK.<br /><searchLink fieldCode="AU" term="%22Ler+AJ%22">Ler AJ</searchLink>; Imperial College London, Department of Chemistry, Molecular Sciences Research Hub, 82 Wood Lane, London, UK.<br /><searchLink fieldCode="AU" term="%22Sanchez-Cabanillas+C%22">Sanchez-Cabanillas C</searchLink>; Imperial College London, Department of Chemistry, Molecular Sciences Research Hub, 82 Wood Lane, London, UK.; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, 123 Old Brompton Road, London, UK.<br /><searchLink fieldCode="AU" term="%22Maher+TE%22">Maher TE</searchLink>; Imperial College London, Department of Chemistry, Molecular Sciences Research Hub, 82 Wood Lane, London, UK.; Imperial College London, Institute of Chemical Biology, Molecular Sciences Research Hub, 82 Wood Lane, London, UK.<br /><searchLink fieldCode="AU" term="%22Fan+E%22">Fan E</searchLink>; Imperial College London, Department of Chemistry, Molecular Sciences Research Hub, 82 Wood Lane, London, UK.<br /><searchLink fieldCode="AU" term="%22Guneri+D%22">Guneri D</searchLink>; UCL School of Pharmacy, 29-39 Brunswick Square, London, UK.<br /><searchLink fieldCode="AU" term="%22Flint+G%22">Flint G</searchLink>; Imperial College London, Department of Chemistry, Molecular Sciences Research Hub, 82 Wood Lane, London, UK.; Imperial College London, Institute of Chemical Biology, Molecular Sciences Research Hub, 82 Wood Lane, London, UK.<br /><searchLink fieldCode="AU" term="%22Zhu+M%22">Zhu M</searchLink>; Imperial College London, Department of Chemistry, Molecular Sciences Research Hub, 82 Wood Lane, London, UK.<br /><searchLink fieldCode="AU" term="%22Liu+LS%22">Liu LS</searchLink>; Imperial College London, Department of Chemistry, Molecular Sciences Research Hub, 82 Wood Lane, London, UK.<br /><searchLink fieldCode="AU" term="%22Fullenkamp+CR%22">Fullenkamp CR</searchLink>; Chemical Biology Laboratory, National Cancer Institute, Frederick, MD, USA.<br /><searchLink fieldCode="AU" term="%22Waller+Z%22">Waller Z</searchLink>; UCL School of Pharmacy, 29-39 Brunswick Square, London, UK.<br /><searchLink fieldCode="AU" term="%22Magnani+L%22">Magnani L</searchLink>; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, 123 Old Brompton Road, London, UK.; Department of Oncology and Haemato-Oncology, Università degli Studi di Milano, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Schneekloth+JS+Jr%22">Schneekloth JS Jr</searchLink>; Chemical Biology Laboratory, National Cancer Institute, Frederick, MD, USA.<br /><searchLink fieldCode="AU" term="%22Di+Antonio+M%22">Di Antonio M</searchLink>; Imperial College London, Department of Chemistry, Molecular Sciences Research Hub, 82 Wood Lane, London, UK. m.di-antonio@imperial.ac.uk.; Imperial College London, Institute of Chemical Biology, Molecular Sciences Research Hub, 82 Wood Lane, London, UK. m.di-antonio@imperial.ac.uk.; The Francis Crick Institute, 1 Midland Road, London, UK. m.di-antonio@imperial.ac.uk. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2025 Dec 09; Vol. 17 (1), pp. 385. <i>Date of Electronic Publication: </i>2025 Dec 09. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Group%22">Nature Pub. 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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/s41467-025-67074-z Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 385 Titles: – TitleFull: Chemically modified CRISPR-Cas9 enables targeting of individual G-quadruplex and i-motif structures, revealing ligand-dependent transcriptional perturbation. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Nuccio SP – PersonEntity: Name: NameFull: Cadoni E – PersonEntity: Name: NameFull: Nikoloudaki R – PersonEntity: Name: NameFull: Galli S – PersonEntity: Name: NameFull: Ler AJ – PersonEntity: Name: NameFull: Sanchez-Cabanillas C – PersonEntity: Name: NameFull: Maher TE – PersonEntity: Name: NameFull: Fan E – PersonEntity: Name: NameFull: Guneri D – PersonEntity: Name: NameFull: Flint G – PersonEntity: Name: NameFull: Zhu M – PersonEntity: Name: NameFull: Liu LS – PersonEntity: Name: NameFull: Fullenkamp CR – PersonEntity: Name: NameFull: Waller Z – PersonEntity: Name: NameFull: Magnani L – PersonEntity: Name: NameFull: Schneekloth JS Jr – PersonEntity: Name: NameFull: Di Antonio M IsPartOfRelationships: – BibEntity: Dates: – D: 09 M: 12 Text: 2025 Dec 09 Type: published Y: 2025 Identifiers: – Type: issn-electronic Value: 2041-1723 Numbering: – Type: volume Value: 17 – Type: issue Value: 1 Titles: – TitleFull: Nature communications Type: main |
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