Structural Mimics of Hydrocarbon Intermediates Reveal Counterclockwise Cyclization Pathways in the Sesquiterpene Synthases TmS and NcECS.

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Title: Structural Mimics of Hydrocarbon Intermediates Reveal Counterclockwise Cyclization Pathways in the Sesquiterpene Synthases TmS and NcECS.
Authors: Groll M; Center for Protein Assemblies, Department Bioscience, School of Natural Sciences, Technical University Munich, Ernst-Otto-Fischer-Straße 8, 85748 Garching, Germany., Li H; Kekulé Institute for Organic Chemistry and Biochemistry, University of Bonn, Gerhard-Domagk-Straße 1, 53121 Bonn, Germany., Troycke P; Center for Protein Assemblies, Department Bioscience, School of Natural Sciences, Technical University Munich, Ernst-Otto-Fischer-Straße 8, 85748 Garching, Germany., Kaila VRI; Department of Biochemistry and Biophysics, Stockholm University, Svante Arrhenius väg 16C, 10691 Stockholm, Sweden., Dickschat JS; Kekulé Institute for Organic Chemistry and Biochemistry, University of Bonn, Gerhard-Domagk-Straße 1, 53121 Bonn, Germany.
Source: Journal of the American Chemical Society [J Am Chem Soc] 2025 Dec 24; Vol. 147 (51), pp. 47742-47750. Date of Electronic Publication: 2025 Dec 10.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 7503056 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5126 (Electronic) Linking ISSN: 00027863 NLM ISO Abbreviation: J Am Chem Soc Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1520-5126
DOI:10.1021/jacs.5c17732