Aberrant cytoplasmic localization of MLH1 characterizes a cell population that seeds breast cancer recurrence.

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Title: Aberrant cytoplasmic localization of MLH1 characterizes a cell population that seeds breast cancer recurrence.
Authors: Mazumder A; Department of Biology, San Diego State University, San Diego, CA, USA.; Cancer Biology and Signaling Program, UCSD Moores Cancer Center, San Diego, CA, USA., Dewitt J; Department of Biology, San Diego State University, San Diego, CA, USA.; Cancer Biology and Signaling Program, UCSD Moores Cancer Center, San Diego, CA, USA., Oropeza E; Department of Biology, San Diego State University, San Diego, CA, USA., Punturi N; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA., Lozano D; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA., Raghunathan M; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA., Piscitelli J; Department of Chemistry, Temple University, Philadelphia, PA, USA., Sajjadi E; Division of Pathology, European Institute of Oncology IRCCS, Milan, Italy.; Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy., GueriniRocco E; Division of Pathology, European Institute of Oncology IRCCS, Milan, Italy.; Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy., Venetis K; Division of Pathology, European Institute of Oncology IRCCS, Milan, Italy.; Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy., Ivanova M; Division of Pathology, European Institute of Oncology IRCCS, Milan, Italy., Mane E; Division of Pathology, European Institute of Oncology IRCCS, Milan, Italy., Dercole M; Division of Pathology, European Institute of Oncology IRCCS, Milan, Italy., Concardi A; Division of Pathology, European Institute of Oncology IRCCS, Milan, Italy., Fusco N; Division of Pathology, European Institute of Oncology IRCCS, Milan, Italy.; Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy., Manhart C; Department of Chemistry, Temple University, Philadelphia, PA, USA., Bainbridge M; Rady Children's Institute for Genomic Medicine (RCIGM), San Diego, CA, USA., Haricharan S; Department of Biology, San Diego State University, San Diego, CA, USA. sharicharan@sdsu.edu.; Cancer Biology and Signaling Program, UCSD Moores Cancer Center, San Diego, CA, USA. sharicharan@sdsu.edu.
Source: Nature communications [Nat Commun] 2025 Dec 10; Vol. 17 (1), pp. 564. Date of Electronic Publication: 2025 Dec 10.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2041-1723
DOI:10.1038/s41467-025-67257-8