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Novel 1H-1,2,3-Triazole Derivatives of Praziquantel with TRPMPZQ Modulatory Activity and Antiparasitic Effects on Larvae, Juvenile, and Adult Worms of Schistosoma mansoni.

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Title: Novel 1H-1,2,3-Triazole Derivatives of Praziquantel with TRPMPZQ Modulatory Activity and Antiparasitic Effects on Larvae, Juvenile, and Adult Worms of Schistosoma mansoni.
Authors: Junior FPS; Laboratório de Bioquímica Experimental e Computacional de Fármacos, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro 21040-900, Brazil., Dantas RF; Laboratório de Bioquímica Experimental e Computacional de Fármacos, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro 21040-900, Brazil., Park SK; Department of Cell Biology, Neurobiology & Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, United States., Whiteland H; Department of Life Sciences, Aberystwyth University, Edward Llwyd Building, Aberystwyth SY23 3DA, U.K., Oliveira CTDS; Laboratório de Síntese Orgânica e Prospecção Biológica, Universidade Federal do Rio de Janeiro, Instituto de Química, Departamento de Química Orgânica, Rio de Janeiro 21941-590, Brazil., Rezende-Neto JM; Laboratório de Bioquímica Experimental e Computacional de Fármacos, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro 21040-900, Brazil., Reis JF; Laboratório de Bioquímica Experimental e Computacional de Fármacos, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro 21040-900, Brazil., Forde-Thomas J; Department of Life Sciences, Aberystwyth University, Edward Llwyd Building, Aberystwyth SY23 3DA, U.K., Gomes LP; Laboratório de Bioquímica Experimental e Computacional de Fármacos, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro 21040-900, Brazil., Valente WCG; Laboratório de Bioquímica Experimental e Computacional de Fármacos, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro 21040-900, Brazil., Schirato GV; Laboratório de Bioquímica Experimental e Computacional de Fármacos, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro 21040-900, Brazil., Noronha FRC Jr; Laboratório de Síntese Orgânica e Prospecção Biológica, Universidade Federal do Rio de Janeiro, Instituto de Química, Departamento de Química Orgânica, Rio de Janeiro 21941-590, Brazil., Hoffmann KF; Department of Life Sciences, Aberystwyth University, Edward Llwyd Building, Aberystwyth SY23 3DA, U.K., Marchant JS; Department of Cell Biology, Neurobiology & Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, United States., Ferreira SB; Laboratório de Síntese Orgânica e Prospecção Biológica, Universidade Federal do Rio de Janeiro, Instituto de Química, Departamento de Química Orgânica, Rio de Janeiro 21941-590, Brazil.
Source: ACS infectious diseases [ACS Infect Dis] 2026 Apr 10; Vol. 12 (4), pp. 1301-1312. Date of Electronic Publication: 2025 Dec 10.
Publication Type: Journal Article
Journal Info: Publisher: ACS Publications Country of Publication: United States NLM ID: 101654580 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2373-8227 (Electronic) Linking ISSN: 23738227 NLM ISO Abbreviation: ACS Infect Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Novel 1H-1,2,3-Triazole Derivatives of Praziquantel with TRPM<subscript>PZQ</subscript> Modulatory Activity and Antiparasitic Effects on Larvae, Juvenile, and Adult Worms of Schistosoma mansoni.
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  Data: <searchLink fieldCode="AU" term="%22Junior+FPS%22">Junior FPS</searchLink>; Laboratório de Bioquímica Experimental e Computacional de Fármacos, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro 21040-900, Brazil.<br /><searchLink fieldCode="AU" term="%22Dantas+RF%22">Dantas RF</searchLink>; Laboratório de Bioquímica Experimental e Computacional de Fármacos, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro 21040-900, Brazil.<br /><searchLink fieldCode="AU" term="%22Park+SK%22">Park SK</searchLink>; Department of Cell Biology, Neurobiology & Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, United States.<br /><searchLink fieldCode="AU" term="%22Whiteland+H%22">Whiteland H</searchLink>; Department of Life Sciences, Aberystwyth University, Edward Llwyd Building, Aberystwyth SY23 3DA, U.K.<br /><searchLink fieldCode="AU" term="%22Oliveira+CTDS%22">Oliveira CTDS</searchLink>; Laboratório de Síntese Orgânica e Prospecção Biológica, Universidade Federal do Rio de Janeiro, Instituto de Química, Departamento de Química Orgânica, Rio de Janeiro 21941-590, Brazil.<br /><searchLink fieldCode="AU" term="%22Rezende-Neto+JM%22">Rezende-Neto JM</searchLink>; Laboratório de Bioquímica Experimental e Computacional de Fármacos, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro 21040-900, Brazil.<br /><searchLink fieldCode="AU" term="%22Reis+JF%22">Reis JF</searchLink>; Laboratório de Bioquímica Experimental e Computacional de Fármacos, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro 21040-900, Brazil.<br /><searchLink fieldCode="AU" term="%22Forde-Thomas+J%22">Forde-Thomas J</searchLink>; Department of Life Sciences, Aberystwyth University, Edward Llwyd Building, Aberystwyth SY23 3DA, U.K.<br /><searchLink fieldCode="AU" term="%22Gomes+LP%22">Gomes LP</searchLink>; Laboratório de Bioquímica Experimental e Computacional de Fármacos, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro 21040-900, Brazil.<br /><searchLink fieldCode="AU" term="%22Valente+WCG%22">Valente WCG</searchLink>; Laboratório de Bioquímica Experimental e Computacional de Fármacos, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro 21040-900, Brazil.<br /><searchLink fieldCode="AU" term="%22Schirato+GV%22">Schirato GV</searchLink>; Laboratório de Bioquímica Experimental e Computacional de Fármacos, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro 21040-900, Brazil.<br /><searchLink fieldCode="AU" term="%22Noronha+FRC+Jr%22">Noronha FRC Jr</searchLink>; Laboratório de Síntese Orgânica e Prospecção Biológica, Universidade Federal do Rio de Janeiro, Instituto de Química, Departamento de Química Orgânica, Rio de Janeiro 21941-590, Brazil.<br /><searchLink fieldCode="AU" term="%22Hoffmann+KF%22">Hoffmann KF</searchLink>; Department of Life Sciences, Aberystwyth University, Edward Llwyd Building, Aberystwyth SY23 3DA, U.K.<br /><searchLink fieldCode="AU" term="%22Marchant+JS%22">Marchant JS</searchLink>; Department of Cell Biology, Neurobiology & Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, United States.<br /><searchLink fieldCode="AU" term="%22Ferreira+SB%22">Ferreira SB</searchLink>; Laboratório de Síntese Orgânica e Prospecção Biológica, Universidade Federal do Rio de Janeiro, Instituto de Química, Departamento de Química Orgânica, Rio de Janeiro 21941-590, Brazil.
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  Data: <searchLink fieldCode="JN" term="%22101654580%22">ACS infectious diseases</searchLink> [ACS Infect Dis] 2026 Apr 10; Vol. 12 (4), pp. 1301-1312. <i>Date of Electronic Publication: </i>2025 Dec 10.
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