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Confirmation of p-tau Ser356's association with Alzheimer's disease pathology and lowering in response to WZ4003 treatment in brain slice cultures. Reply to: "Phospho-tau Ser356 is mostly confined to pre-NFT neurons in Alzheimer's pathology".

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Title: Confirmation of p-tau Ser356's association with Alzheimer's disease pathology and lowering in response to WZ4003 treatment in brain slice cultures. Reply to: "Phospho-tau Ser356 is mostly confined to pre-NFT neurons in Alzheimer's pathology".
Authors: Taylor LW; Institute for Neuroscience and Cardiovascular Research, 1 George Square, The University of Edinburgh, Edinburgh, UK.; UK Dementia Research Institute at The University of Edinburgh, Edinburgh, UK., Simzer EM; Institute for Neuroscience and Cardiovascular Research, 1 George Square, The University of Edinburgh, Edinburgh, UK.; UK Dementia Research Institute at The University of Edinburgh, Edinburgh, UK., Young LFP; Institute for Neuroscience and Cardiovascular Research, 1 George Square, The University of Edinburgh, Edinburgh, UK.; UK Dementia Research Institute at The University of Edinburgh, Edinburgh, UK., Holt K; Institute for Neuroscience and Cardiovascular Research, 1 George Square, The University of Edinburgh, Edinburgh, UK.; UK Dementia Research Institute at The University of Edinburgh, Edinburgh, UK., Spires-Jones TL; Institute for Neuroscience and Cardiovascular Research, 1 George Square, The University of Edinburgh, Edinburgh, UK.; UK Dementia Research Institute at The University of Edinburgh, Edinburgh, UK., Durrant CS; Institute for Neuroscience and Cardiovascular Research, 1 George Square, The University of Edinburgh, Edinburgh, UK. claire.durrant@ed.ac.uk.; UK Dementia Research Institute at The University of Edinburgh, Edinburgh, UK. claire.durrant@ed.ac.uk.
Source: Acta neuropathologica [Acta Neuropathol] 2025 Dec 11; Vol. 150 (1), pp. 63. Date of Electronic Publication: 2025 Dec 11.
Publication Type: Letter
Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0412041 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-0533 (Electronic) Linking ISSN: 00016322 NLM ISO Abbreviation: Acta Neuropathol Subsets: MEDLINE; In Process
Database: MEDLINE Ultimate
Description
ISSN:1432-0533
DOI:10.1007/s00401-025-02966-4