Structural basis of PANX1 permeation and positive modulation by mefloquine.
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| Title: | Structural basis of PANX1 permeation and positive modulation by mefloquine. |
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| Authors: | Li Y; Department of Molecular Biosciences, Northwestern University, Evanston, IL, USA., Ruan Z; Department of Structural Biology, Van Andel Institute, Grand Rapids, MI, USA.; Department of Biochemistry & Molecular Biology, Thomas Jefferson University, Philadelphia, PA, USA., Lee J; Department of Molecular Biosciences, Northwestern University, Evanston, IL, USA., Orozco IJ; Department of Structural Biology, Van Andel Institute, Grand Rapids, MI, USA.; AnaBios Corporation, San Diego, CA, USA., Zhou E; Department of Molecular Biosciences, Northwestern University, Evanston, IL, USA., Du J; Department of Molecular Biosciences, Northwestern University, Evanston, IL, USA. juan.du@northwestern.edu.; Department of Structural Biology, Van Andel Institute, Grand Rapids, MI, USA. juan.du@northwestern.edu.; Department of Pharmacology, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA. juan.du@northwestern.edu.; Chemistry of Life Processes Institute, Northwestern University, Evanston, IL, USA. juan.du@northwestern.edu., Lü W; Department of Molecular Biosciences, Northwestern University, Evanston, IL, USA. wei.lu@northwestern.edu.; Department of Structural Biology, Van Andel Institute, Grand Rapids, MI, USA. wei.lu@northwestern.edu.; Department of Pharmacology, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA. wei.lu@northwestern.edu.; Chemistry of Life Processes Institute, Northwestern University, Evanston, IL, USA. wei.lu@northwestern.edu. |
| Source: | Nature communications [Nat Commun] 2025 Dec 11; Vol. 16 (1), pp. 11057. Date of Electronic Publication: 2025 Dec 11. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-025-66028-9 |
