RBM7 suppresses mitochondrial dysfunction and ferroptosis by destabilizing FBXL16 mRNA to enhance Temozolomide resistance in glioblastoma.

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Title: RBM7 suppresses mitochondrial dysfunction and ferroptosis by destabilizing FBXL16 mRNA to enhance Temozolomide resistance in glioblastoma.
Authors: Liu N; College of Life Sciences and Health, Wuhan University of Science and Technology, No.10, Huangjiahu West Road, Hongshan District, Wuhan, 430065, Hubei Province, China.; Guangdong Provincial Science and Technology Expert Workstation, Huizhou Central People's Hospital, Huizhou, 516001, Guangdong Province, China., Cui Y; College of Life Sciences and Health, Wuhan University of Science and Technology, No.10, Huangjiahu West Road, Hongshan District, Wuhan, 430065, Hubei Province, China.; Guangdong Provincial Science and Technology Expert Workstation, Huizhou Central People's Hospital, Huizhou, 516001, Guangdong Province, China., Li J; Department of Neurosurgery, Xijing Hospital, Fourth Military Medical University, No.127, Changle West Road,, Xi'an, 710032, Shaanxi Province, China., Li S; Science Research Center, Huizhou Central People's Hospital, Huizhou, 516001, Guangdong Province, China., Tu Y; Science Research Center, Huizhou Central People's Hospital, Huizhou, 516001, Guangdong Province, China., Huo J; Department of Neurosurgery, Xijing Hospital, Fourth Military Medical University, No.127, Changle West Road,, Xi'an, 710032, Shaanxi Province, China., Zhang T; College of Life Sciences and Health, Wuhan University of Science and Technology, No.10, Huangjiahu West Road, Hongshan District, Wuhan, 430065, Hubei Province, China. zhangtongcun@wust.edu.cn.; Guangdong Provincial Science and Technology Expert Workstation, Huizhou Central People's Hospital, Huizhou, 516001, Guangdong Province, China. zhangtongcun@wust.edu.cn., Zhen H; Department of Neurosurgery, Xijing Hospital, Fourth Military Medical University, No.127, Changle West Road,, Xi'an, 710032, Shaanxi Province, China. zhnhaining@outlook.com.
Source: Molecular genetics and genomics : MGG [Mol Genet Genomics] 2025 Dec 12; Vol. 301 (1), pp. 1. Date of Electronic Publication: 2025 Dec 12.
Publication Type: Journal Article
Journal Info: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 101093320 Publication Model: Electronic Cited Medium: Internet ISSN: 1617-4623 (Electronic) Linking ISSN: 16174623 NLM ISO Abbreviation: Mol Genet Genomics Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1617-4623
DOI:10.1007/s00438-025-02313-y