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Germline Pathogenic Variants Among Women Without a History of Breast Cancer: A Secondary Analysis of the WISDOM Randomized Clinical Trial.

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Title: Germline Pathogenic Variants Among Women Without a History of Breast Cancer: A Secondary Analysis of the WISDOM Randomized Clinical Trial.
Authors: Fergus KB; Cancer Genetics and Prevention Program, University of California, San Francisco., Ross KS; Cancer Genetics and Prevention Program, University of California, San Francisco., Scheuner MT; San Francisco VA Health Care System, San Francisco, California.; Department of Medicine/Hematology-Oncology, University of California, San Francisco.; Department of Pediatrics/Medical Genetics, University of California, San Francisco., Blanco AM; Cancer Genetics and Prevention Program, University of California, San Francisco., Tice JA; Division of General Internal Medicine, Department of Medicine, University of California, San Francisco., Ziv E; Cancer Genetics and Prevention Program, University of California, San Francisco., Shieh Y; Department of Population Health Sciences, Weill Cornell Medicine, New York, New York., van 't Veer L; Department of Laboratory Medicine, University of California, San Francisco., Olopade OI; Section of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, Illinois., Goodman DL; Department of Epidemiology, University of California, Irvine., Tong BS; Cancer Genetics and Prevention Program, University of California, San Francisco., Harvey H; Sanford Health, Sioux Falls, South Dakota., DeRosa D; Moores UCSD Cancer Center, University of California, San Diego, La Jolla., Risty L; Edith Sanford Breast Cancer, Sanford Health, Fargo, North Dakota., Silver E; Division of Hematology-Oncology, Department of Medicine, David Geffen School of Medicine at UCLA, University of California, Los Angeles., Kaster A; Edith Sanford Breast Cancer, Sanford Health, Fargo, North Dakota., Fiscalini AS; Department of Surgery, University of California, San Francisco., Blum K; Cancer Genetics and Prevention Program, University of California, San Francisco., Heise R; Department of Population Health Sciences, Weill Cornell Medicine, New York, New York., Sabacan L; Department of Surgery, University of California, San Francisco., Heditsian D; Breast Science Advocacy Core, University of California, San Francisco., Brain S; Breast Science Advocacy Core, University of California, San Francisco., Petruse A; Division of Hematology-Oncology, Department of Medicine, David Geffen School of Medicine at UCLA, University of California, Los Angeles., Eklund M; Karolinska Institutet, Stockholm, Sweden., Hiatt RA; Department of Epidemiology & Biostatistics, University of California, San Francisco.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco., Borowsky AD; University of California, Davis, Sacramento., Naeim A; Division of Hematology-Oncology, Department of Medicine, David Geffen School of Medicine at UCLA, University of California, Los Angeles., Park HL; Department of Pathology & Laboratory Medicine, University of California, Irvine.; Department of Epidemiology & Biostatistics, University of California, Irvine., LaCroix AZ; Herbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, La Jolla., Parker BA; Moores UCSD Cancer Center, University of California, San Diego, La Jolla., Lancaster R; University of Alabama at Birmingham., Esserman J; Diagnostic Center of Miami, Miami, Florida., Wenger N; Division of Hematology-Oncology, Department of Medicine, David Geffen School of Medicine at UCLA, University of California, Los Angeles., Arasu V; Division of Research, Kaiser Permanente Division of Research, Pleasanton, California., Anton-Culver H; Department of Epidemiology, University of California, Irvine., Esserman LJ; Cancer Genetics and Prevention Program, University of California, San Francisco., Madlensky L; Moores UCSD Cancer Center, University of California, San Diego, La Jolla.; Division of Genomics and Precision Medicine, Department of Medicine, University of California, San Diego, La Jolla.
Source: JAMA internal medicine [JAMA Intern Med] 2026 Mar 01; Vol. 186 (3), pp. 344-352.
Publication Type: Journal Article; Randomized Controlled Trial; Pragmatic Clinical Trial
Journal Info: Publisher: American Medical Association Country of Publication: United States NLM ID: 101589534 Publication Model: Print Cited Medium: Internet ISSN: 2168-6114 (Electronic) Linking ISSN: 21686106 NLM ISO Abbreviation: JAMA Intern Med Subsets: MEDLINE
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  Data: Germline Pathogenic Variants Among Women Without a History of Breast Cancer: A Secondary Analysis of the WISDOM Randomized Clinical Trial.
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Cancer Genetics and Prevention Program, University of California, San Francisco.<br /><searchLink fieldCode="AU" term="%22Shieh+Y%22">Shieh Y</searchLink>; Department of Population Health Sciences, Weill Cornell Medicine, New York, New York.<br /><searchLink fieldCode="AU" term="%22van+'t+Veer+L%22">van 't Veer L</searchLink>; Department of Laboratory Medicine, University of California, San Francisco.<br /><searchLink fieldCode="AU" term="%22Olopade+OI%22">Olopade OI</searchLink>; Section of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, Illinois.<br /><searchLink fieldCode="AU" term="%22Goodman+DL%22">Goodman DL</searchLink>; Department of Epidemiology, University of California, Irvine.<br /><searchLink fieldCode="AU" term="%22Tong+BS%22">Tong BS</searchLink>; Cancer Genetics and Prevention Program, University of California, San Francisco.<br /><searchLink fieldCode="AU" term="%22Harvey+H%22">Harvey H</searchLink>; Sanford Health, Sioux Falls, South Dakota.<br /><searchLink fieldCode="AU" term="%22DeRosa+D%22">DeRosa D</searchLink>; 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Diagnostic Center of Miami, Miami, Florida.<br /><searchLink fieldCode="AU" term="%22Wenger+N%22">Wenger N</searchLink>; Division of Hematology-Oncology, Department of Medicine, David Geffen School of Medicine at UCLA, University of California, Los Angeles.<br /><searchLink fieldCode="AU" term="%22Arasu+V%22">Arasu V</searchLink>; Division of Research, Kaiser Permanente Division of Research, Pleasanton, California.<br /><searchLink fieldCode="AU" term="%22Anton-Culver+H%22">Anton-Culver H</searchLink>; Department of Epidemiology, University of California, Irvine.<br /><searchLink fieldCode="AU" term="%22Esserman+LJ%22">Esserman LJ</searchLink>; Cancer Genetics and Prevention Program, University of California, San Francisco.<br /><searchLink fieldCode="AU" term="%22Madlensky+L%22">Madlensky L</searchLink>; Moores UCSD Cancer Center, University of California, San Diego, La Jolla.; Division of Genomics and Precision Medicine, Department of Medicine, University of California, San Diego, La Jolla.
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