Excessive IL-4 environment enhances osteoclastogenesis and modulates inflammatory cell differentiation in bone loss associated with food allergic enteropathy.

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Title: Excessive IL-4 environment enhances osteoclastogenesis and modulates inflammatory cell differentiation in bone loss associated with food allergic enteropathy.
Authors: Soga K; Research Center for Food Safety, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan., Hoshino T; Research Center for Food Safety, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan., Tamai M; Research Center for Food Safety, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan., Itoh A; Ito Bone Histomorphometry Institute for the Histological Analysis and Histomorphometry, Niigata, Japan., Uno S; Research Center for Food Safety, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan., Nishitsuji K; Research Center for Food Safety, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan., Hashiguchi M; Department of Immunobiology and Biofunctional Research, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan., Nakamura S; Research Center for Food Safety, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan., Isogaki R; Research Center for Food Safety, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan., Takane K; Research Center for Food Safety, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan., Yamazaki F; Wellness Science Labs, Meiji Holdings Co., Ltd., Tokyo, Japan., Furuhata A; Laboratory of Morphology and Image Analysis, Biomedical Research Core Facilities, Graduate School of Medicine, Juntendo University, Tokyo, Japan., Kakuta S; Research Center for Food Safety, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan; Laboratory of Biomedical Science, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan; Collaborative Research Institute for Innovative Microbiology, The University of Tokyo, Tokyo, Japan., Matsuoka S; Department of Immunological Diagnosis, Graduate School of Medicine, Juntendo University, Tokyo, Japan., Tomura M; Laboratory of Immunology, Faculty of Pharmacy, Osaka Ohtani University, Osaka, Japan., Shimojo N; Chiba University Hospital Allergy Center, Chiba University, Chiba, Japan., Hachimura S; Research Center for Food Safety, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan; Department of Immunobiology and Biofunctional Research, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan., Nakajima-Adachi H; Research Center for Food Safety, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan; Department of Immunobiology and Biofunctional Research, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan. Electronic address: haruyona@g.ecc.u-tokyo.ac.jp.
Source: Allergology international : official journal of the Japanese Society of Allergology [Allergol Int] 2026 Apr; Vol. 75 (2), pp. 267-277. Date of Electronic Publication: 2025 Dec 11.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 9616296 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1440-1592 (Electronic) Linking ISSN: 13238930 NLM ISO Abbreviation: Allergol Int Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Excessive IL-4 environment enhances osteoclastogenesis and modulates inflammatory cell differentiation in bone loss associated with food allergic enteropathy.
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  Data: <searchLink fieldCode="AU" term="%22Soga+K%22">Soga K</searchLink>; Research Center for Food Safety, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Hoshino+T%22">Hoshino T</searchLink>; Research Center for Food Safety, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Tamai+M%22">Tamai M</searchLink>; Research Center for Food Safety, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Itoh+A%22">Itoh A</searchLink>; Ito Bone Histomorphometry Institute for the Histological Analysis and Histomorphometry, Niigata, Japan.<br /><searchLink fieldCode="AU" term="%22Uno+S%22">Uno S</searchLink>; Research Center for Food Safety, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Nishitsuji+K%22">Nishitsuji K</searchLink>; Research Center for Food Safety, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Hashiguchi+M%22">Hashiguchi M</searchLink>; Department of Immunobiology and Biofunctional Research, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Nakamura+S%22">Nakamura S</searchLink>; Research Center for Food Safety, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Isogaki+R%22">Isogaki R</searchLink>; Research Center for Food Safety, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Takane+K%22">Takane K</searchLink>; Research Center for Food Safety, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Yamazaki+F%22">Yamazaki F</searchLink>; Wellness Science Labs, Meiji Holdings Co., Ltd., Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Furuhata+A%22">Furuhata A</searchLink>; Laboratory of Morphology and Image Analysis, Biomedical Research Core Facilities, Graduate School of Medicine, Juntendo University, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Kakuta+S%22">Kakuta S</searchLink>; Research Center for Food Safety, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan; Laboratory of Biomedical Science, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan; Collaborative Research Institute for Innovative Microbiology, The University of Tokyo, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Matsuoka+S%22">Matsuoka S</searchLink>; Department of Immunological Diagnosis, Graduate School of Medicine, Juntendo University, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Tomura+M%22">Tomura M</searchLink>; Laboratory of Immunology, Faculty of Pharmacy, Osaka Ohtani University, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Shimojo+N%22">Shimojo N</searchLink>; Chiba University Hospital Allergy Center, Chiba University, Chiba, Japan.<br /><searchLink fieldCode="AU" term="%22Hachimura+S%22">Hachimura S</searchLink>; Research Center for Food Safety, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan; Department of Immunobiology and Biofunctional Research, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Nakajima-Adachi+H%22">Nakajima-Adachi H</searchLink>; Research Center for Food Safety, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan; Department of Immunobiology and Biofunctional Research, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan. Electronic address: haruyona@g.ecc.u-tokyo.ac.jp.
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  Data: <searchLink fieldCode="JN" term="%229616296%22">Allergology international : official journal of the Japanese Society of Allergology</searchLink> [Allergol Int] 2026 Apr; Vol. 75 (2), pp. 267-277. <i>Date of Electronic Publication: </i>2025 Dec 11.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9616296 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1440-1592 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2213238930%22">13238930 </searchLink><i>NLM ISO Abbreviation: </i>Allergol Int <i>Subsets: </i>MEDLINE
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