Liver-specific paraoxonase-1 alleviates regulatory T cell-driven immunosuppression via metabolic reprogramming in hepatocellular carcinoma.
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| Title: | Liver-specific paraoxonase-1 alleviates regulatory T cell-driven immunosuppression via metabolic reprogramming in hepatocellular carcinoma. |
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| Authors: | Lu Z; Institute of Clinical Sciences, Zhongshan Hospital, Fudan University, Shanghai, China. lu.zhou1@zs-hospital.sh.cn.; Fudan Biotherapy Institute, Zhongshan Hospital, Fudan University, Shanghai, China. lu.zhou1@zs-hospital.sh.cn.; Clinical Center for Biotherapy, Zhongshan Hospital (Xiamen), Fudan University, Xiamen, China. lu.zhou1@zs-hospital.sh.cn., Shi H; Department of hepatobiliary Surgery and liver Transplantation, Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, China., Gao R; Department of hepatobiliary Surgery and liver Transplantation, Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, China., Zhong C; Department of hepatobiliary Surgery and liver Transplantation, Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, China., Zhang W; Institute of Clinical Sciences, Zhongshan Hospital, Fudan University, Shanghai, China., Zhu J; Department of hepatobiliary Surgery and liver Transplantation, Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, China., Huang J; Department of hepatobiliary Surgery and liver Transplantation, Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, China., Liu R; Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, China.; Key Laboratory of Medical Epigenetics and Metabolism, Institutes of Biomedical Sciences, Fudan University, Shanghai, China.; Shanghai Fifth People's Hospital, Fudan University, Shanghai, China., Xing Y; Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, China.; Key Laboratory of Medical Epigenetics and Metabolism, Institutes of Biomedical Sciences, Fudan University, Shanghai, China., Chu Y; Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, China.; Key Laboratory of Medical Epigenetics and Metabolism, Institutes of Biomedical Sciences, Fudan University, Shanghai, China., Sun H; Department of hepatobiliary Surgery and liver Transplantation, Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, China., Shi G; Department of hepatobiliary Surgery and liver Transplantation, Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, China., Ke A; Department of hepatobiliary Surgery and liver Transplantation, Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, China., Zhou J; Department of hepatobiliary Surgery and liver Transplantation, Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, China., Cai J; Department of hepatobiliary Surgery and liver Transplantation, Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, China., Fan J; Department of hepatobiliary Surgery and liver Transplantation, Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, China., Gao P; Endoscopy Center and Endoscopy Research Institute, Fudan University, Shanghai, China. gao.pingting@zs-hospital.sh.cn., Huang C; Department of hepatobiliary Surgery and liver Transplantation, Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, China. huang.cheng@zs-hospital.sh.cn. |
| Source: | Nature communications [Nat Commun] 2025 Dec 12; Vol. 16 (1), pp. 11034. Date of Electronic Publication: 2025 Dec 12. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-025-66168-y |
