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Liver-specific paraoxonase-1 alleviates regulatory T cell-driven immunosuppression via metabolic reprogramming in hepatocellular carcinoma.

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Title: Liver-specific paraoxonase-1 alleviates regulatory T cell-driven immunosuppression via metabolic reprogramming in hepatocellular carcinoma.
Authors: Lu Z; Institute of Clinical Sciences, Zhongshan Hospital, Fudan University, Shanghai, China. lu.zhou1@zs-hospital.sh.cn.; Fudan Biotherapy Institute, Zhongshan Hospital, Fudan University, Shanghai, China. lu.zhou1@zs-hospital.sh.cn.; Clinical Center for Biotherapy, Zhongshan Hospital (Xiamen), Fudan University, Xiamen, China. lu.zhou1@zs-hospital.sh.cn., Shi H; Department of hepatobiliary Surgery and liver Transplantation, Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, China., Gao R; Department of hepatobiliary Surgery and liver Transplantation, Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, China., Zhong C; Department of hepatobiliary Surgery and liver Transplantation, Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, China., Zhang W; Institute of Clinical Sciences, Zhongshan Hospital, Fudan University, Shanghai, China., Zhu J; Department of hepatobiliary Surgery and liver Transplantation, Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, China., Huang J; Department of hepatobiliary Surgery and liver Transplantation, Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, China., Liu R; Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, China.; Key Laboratory of Medical Epigenetics and Metabolism, Institutes of Biomedical Sciences, Fudan University, Shanghai, China.; Shanghai Fifth People's Hospital, Fudan University, Shanghai, China., Xing Y; Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, China.; Key Laboratory of Medical Epigenetics and Metabolism, Institutes of Biomedical Sciences, Fudan University, Shanghai, China., Chu Y; Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, China.; Key Laboratory of Medical Epigenetics and Metabolism, Institutes of Biomedical Sciences, Fudan University, Shanghai, China., Sun H; Department of hepatobiliary Surgery and liver Transplantation, Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, China., Shi G; Department of hepatobiliary Surgery and liver Transplantation, Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, China., Ke A; Department of hepatobiliary Surgery and liver Transplantation, Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, China., Zhou J; Department of hepatobiliary Surgery and liver Transplantation, Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, China., Cai J; Department of hepatobiliary Surgery and liver Transplantation, Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, China., Fan J; Department of hepatobiliary Surgery and liver Transplantation, Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, China., Gao P; Endoscopy Center and Endoscopy Research Institute, Fudan University, Shanghai, China. gao.pingting@zs-hospital.sh.cn., Huang C; Department of hepatobiliary Surgery and liver Transplantation, Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, China. huang.cheng@zs-hospital.sh.cn.
Source: Nature communications [Nat Commun] 2025 Dec 12; Vol. 16 (1), pp. 11034. Date of Electronic Publication: 2025 Dec 12.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Liver-specific paraoxonase-1 alleviates regulatory T cell-driven immunosuppression via metabolic reprogramming in hepatocellular carcinoma.
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  Data: <searchLink fieldCode="AU" term="%22Lu+Z%22">Lu Z</searchLink>; Institute of Clinical Sciences, Zhongshan Hospital, Fudan University, Shanghai, China. lu.zhou1@zs-hospital.sh.cn.; Fudan Biotherapy Institute, Zhongshan Hospital, Fudan University, Shanghai, China. lu.zhou1@zs-hospital.sh.cn.; Clinical Center for Biotherapy, Zhongshan Hospital (Xiamen), Fudan University, Xiamen, China. lu.zhou1@zs-hospital.sh.cn.<br /><searchLink fieldCode="AU" term="%22Shi+H%22">Shi H</searchLink>; Department of hepatobiliary Surgery and liver Transplantation, Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Gao+R%22">Gao R</searchLink>; Department of hepatobiliary Surgery and liver Transplantation, Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Zhong+C%22">Zhong C</searchLink>; Department of hepatobiliary Surgery and liver Transplantation, Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Zhang+W%22">Zhang W</searchLink>; Institute of Clinical Sciences, Zhongshan Hospital, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Zhu+J%22">Zhu J</searchLink>; Department of hepatobiliary Surgery and liver Transplantation, Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Huang+J%22">Huang J</searchLink>; Department of hepatobiliary Surgery and liver Transplantation, Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Liu+R%22">Liu R</searchLink>; Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, China.; Key Laboratory of Medical Epigenetics and Metabolism, Institutes of Biomedical Sciences, Fudan University, Shanghai, China.; Shanghai Fifth People's Hospital, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Xing+Y%22">Xing Y</searchLink>; Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, China.; Key Laboratory of Medical Epigenetics and Metabolism, Institutes of Biomedical Sciences, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Chu+Y%22">Chu Y</searchLink>; Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, China.; Key Laboratory of Medical Epigenetics and Metabolism, Institutes of Biomedical Sciences, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Sun+H%22">Sun H</searchLink>; Department of hepatobiliary Surgery and liver Transplantation, Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Shi+G%22">Shi G</searchLink>; Department of hepatobiliary Surgery and liver Transplantation, Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Ke+A%22">Ke A</searchLink>; Department of hepatobiliary Surgery and liver Transplantation, Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Zhou+J%22">Zhou J</searchLink>; Department of hepatobiliary Surgery and liver Transplantation, Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Cai+J%22">Cai J</searchLink>; Department of hepatobiliary Surgery and liver Transplantation, Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Fan+J%22">Fan J</searchLink>; Department of hepatobiliary Surgery and liver Transplantation, Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Gao+P%22">Gao P</searchLink>; Endoscopy Center and Endoscopy Research Institute, Fudan University, Shanghai, China. gao.pingting@zs-hospital.sh.cn.<br /><searchLink fieldCode="AU" term="%22Huang+C%22">Huang C</searchLink>; Department of hepatobiliary Surgery and liver Transplantation, Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, China. huang.cheng@zs-hospital.sh.cn.
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