Lessons learned in linking PROTACs from discovery to the clinic.
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| Title: | Lessons learned in linking PROTACs from discovery to the clinic. |
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| Authors: | Pike A; DMPK, Oncology R&D, AstraZeneca, Cambridge, UK. andrew.pike@astrazeneca.com., Lee ECY; Medicinal Chemistry, Oncology R&D, AstraZeneca, Boston, MA, USA., Michaelides IN; Hit Discovery, Discovery Sciences, R&D, AstraZeneca, Cambridge, UK., Schade M; Medicinal Chemistry, Oncology R&D, AstraZeneca, Cambridge, UK., Sharma A; Medicinal Chemistry, Oncology R&D, AstraZeneca, Boston, MA, USA., Scott JS; Medicinal Chemistry, Oncology R&D, AstraZeneca, Cambridge, UK., Srivastava A; DMPK, Oncology R&D, AstraZeneca, Cambridge, UK. |
| Source: | Nature reviews. Chemistry [Nat Rev Chem] 2026 Feb; Vol. 10 (2), pp. 117-132. Date of Electronic Publication: 2025 Dec 12. |
| Publication Type: | Journal Article; Review |
| Journal Info: | Publisher: Springer Nature Country of Publication: England NLM ID: 101703631 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2397-3358 (Electronic) Linking ISSN: 23973358 NLM ISO Abbreviation: Nat Rev Chem Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| ISSN: | 2397-3358 |
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| DOI: | 10.1038/s41570-025-00784-6 |
