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Lessons learned in linking PROTACs from discovery to the clinic.

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Title: Lessons learned in linking PROTACs from discovery to the clinic.
Authors: Pike A; DMPK, Oncology R&D, AstraZeneca, Cambridge, UK. andrew.pike@astrazeneca.com., Lee ECY; Medicinal Chemistry, Oncology R&D, AstraZeneca, Boston, MA, USA., Michaelides IN; Hit Discovery, Discovery Sciences, R&D, AstraZeneca, Cambridge, UK., Schade M; Medicinal Chemistry, Oncology R&D, AstraZeneca, Cambridge, UK., Sharma A; Medicinal Chemistry, Oncology R&D, AstraZeneca, Boston, MA, USA., Scott JS; Medicinal Chemistry, Oncology R&D, AstraZeneca, Cambridge, UK., Srivastava A; DMPK, Oncology R&D, AstraZeneca, Cambridge, UK.
Source: Nature reviews. Chemistry [Nat Rev Chem] 2026 Feb; Vol. 10 (2), pp. 117-132. Date of Electronic Publication: 2025 Dec 12.
Publication Type: Journal Article; Review
Journal Info: Publisher: Springer Nature Country of Publication: England NLM ID: 101703631 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2397-3358 (Electronic) Linking ISSN: 23973358 NLM ISO Abbreviation: Nat Rev Chem Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Pike+A%22">Pike A</searchLink>; DMPK, Oncology R&D, AstraZeneca, Cambridge, UK. andrew.pike@astrazeneca.com.<br /><searchLink fieldCode="AU" term="%22Lee+ECY%22">Lee ECY</searchLink>; Medicinal Chemistry, Oncology R&D, AstraZeneca, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Michaelides+IN%22">Michaelides IN</searchLink>; Hit Discovery, Discovery Sciences, R&D, AstraZeneca, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Schade+M%22">Schade M</searchLink>; Medicinal Chemistry, Oncology R&D, AstraZeneca, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Sharma+A%22">Sharma A</searchLink>; Medicinal Chemistry, Oncology R&D, AstraZeneca, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Scott+JS%22">Scott JS</searchLink>; Medicinal Chemistry, Oncology R&D, AstraZeneca, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Srivastava+A%22">Srivastava A</searchLink>; DMPK, Oncology R&D, AstraZeneca, Cambridge, UK.
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  Data: <searchLink fieldCode="JN" term="%22101703631%22">Nature reviews. Chemistry</searchLink> [Nat Rev Chem] 2026 Feb; Vol. 10 (2), pp. 117-132. <i>Date of Electronic Publication: </i>2025 Dec 12.
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              Text: 2026 Feb
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