SIRT2 Inhibition promotes microglia LC3-associated phagocytosis via NRF2/CD36 after the experimental subarachnoid hemorrhage.

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Title: SIRT2 Inhibition promotes microglia LC3-associated phagocytosis via NRF2/CD36 after the experimental subarachnoid hemorrhage.
Authors: Sheng B; Department of Neurosurgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Neurosurgical Institute of Nanjing University, Nanjing, China.; Department of Neurosurgery, The First Affiliated Hospital of Wannan Medical College, (Yijishan Hospital of Wannan Medical College), The Translational Research Institute for Neurological Disorders of Wannan Medical College, Wuhu, China.; Department of Physiology and Pharmacology, Basic Sciences, School of Medicine, Loma Linda University, Loma Linda, CA, 92354, USA.; Department of Neurosurgery, Loma Linda University School of Medicine, Loma Linda, CA, 92354, USA., Chen X; Department of Neurosurgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Neurosurgical Institute of Nanjing University, Nanjing, China., Tao T; Department of Neurosurgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Neurosurgical Institute of Nanjing University, Nanjing, China., Sun J; Department of Neurosurgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Neurosurgical Institute of Nanjing University, Nanjing, China., Li W; Department of Neurosurgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Neurosurgical Institute of Nanjing University, Nanjing, China., Wu L; Department of Neurosurgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Neurosurgical Institute of Nanjing University, Nanjing, China., Peng Z; Department of Neurosurgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Neurosurgical Institute of Nanjing University, Nanjing, China., Li X; Department of Neurosurgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Neurosurgical Institute of Nanjing University, Nanjing, China., Zhou Z; Department of Neurosurgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Neurosurgical Institute of Nanjing University, Nanjing, China., Yu Q; Department of Physiology and Pharmacology, Basic Sciences, School of Medicine, Loma Linda University, Loma Linda, CA, 92354, USA., Ling Y; Department of Physiology and Pharmacology, Basic Sciences, School of Medicine, Loma Linda University, Loma Linda, CA, 92354, USA., Sherchan P; Department of Physiology and Pharmacology, Basic Sciences, School of Medicine, Loma Linda University, Loma Linda, CA, 92354, USA., Flores JJ; Department of Physiology and Pharmacology, Basic Sciences, School of Medicine, Loma Linda University, Loma Linda, CA, 92354, USA., Tang J; Department of Physiology and Pharmacology, Basic Sciences, School of Medicine, Loma Linda University, Loma Linda, CA, 92354, USA., Huang L; Department of Physiology and Pharmacology, Basic Sciences, School of Medicine, Loma Linda University, Loma Linda, CA, 92354, USA. lhuang@llu.edu.; Department of Neurosurgery, Loma Linda University School of Medicine, Loma Linda, CA, 92354, USA. lhuang@llu.edu., Hang C; Department of Neurosurgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Neurosurgical Institute of Nanjing University, Nanjing, China. hang_neurosurgery@163.com., Zhang JH; Department of Physiology and Pharmacology, Basic Sciences, School of Medicine, Loma Linda University, Loma Linda, CA, 92354, USA. johnzhang3910@yahoo.com.; Department of Neurosurgery, Loma Linda University School of Medicine, Loma Linda, CA, 92354, USA. johnzhang3910@yahoo.com.
Source: Journal of neuroinflammation [J Neuroinflammation] 2025 Dec 12; Vol. 23 (1), pp. 26. Date of Electronic Publication: 2025 Dec 12.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101222974 Publication Model: Electronic Cited Medium: Internet ISSN: 1742-2094 (Electronic) Linking ISSN: 17422094 NLM ISO Abbreviation: J Neuroinflammation Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1742-2094
DOI:10.1186/s12974-025-03623-z