APOE isoform-associated tau oligomer polymorphs differ in synaptotoxicity and seeding activity.

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Title: APOE isoform-associated tau oligomer polymorphs differ in synaptotoxicity and seeding activity.
Authors: Moreno N; Mitchell Center for Neurodegenerative Diseases, University of Texas Medical Branch, Galveston, Texas, USA.; Department of Neurology, Neuroscience, and Cell Biology, University of Texas Medical Branch, Galveston, Texas, USA., Shchankin N; Mitchell Center for Neurodegenerative Diseases, University of Texas Medical Branch, Galveston, Texas, USA.; Department of Neurology, Neuroscience, and Cell Biology, University of Texas Medical Branch, Galveston, Texas, USA., Fung L; Mitchell Center for Neurodegenerative Diseases, University of Texas Medical Branch, Galveston, Texas, USA.; Department of Neurology, Neuroscience, and Cell Biology, University of Texas Medical Branch, Galveston, Texas, USA., Puangmalai N; Mitchell Center for Neurodegenerative Diseases, University of Texas Medical Branch, Galveston, Texas, USA.; Department of Neurology, Neuroscience, and Cell Biology, University of Texas Medical Branch, Galveston, Texas, USA., Bhatt N; Mitchell Center for Neurodegenerative Diseases, University of Texas Medical Branch, Galveston, Texas, USA.; Department of Neurology, Neuroscience, and Cell Biology, University of Texas Medical Branch, Galveston, Texas, USA., Haque MA; Mitchell Center for Neurodegenerative Diseases, University of Texas Medical Branch, Galveston, Texas, USA.; Department of Neurology, Neuroscience, and Cell Biology, University of Texas Medical Branch, Galveston, Texas, USA., Zhao Y; Sealy Center for Molecular Medicine, University of Texas Medical Branch, Galveston, Texas, USA., Keene CD; Division of Neuropathology, University of Washington, Seattle, Washington, USA., Limon A; Mitchell Center for Neurodegenerative Diseases, University of Texas Medical Branch, Galveston, Texas, USA.; Department of Neurology, Neuroscience, and Cell Biology, University of Texas Medical Branch, Galveston, Texas, USA., Kayed R; Mitchell Center for Neurodegenerative Diseases, University of Texas Medical Branch, Galveston, Texas, USA.; Department of Neurology, Neuroscience, and Cell Biology, University of Texas Medical Branch, Galveston, Texas, USA.
Source: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2025 Dec; Vol. 21 (12), pp. e70965.
Publication Type: Journal Article
Journal Info: Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1552-5279
DOI:10.1002/alz.70965