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APOE isoform-associated tau oligomer polymorphs differ in synaptotoxicity and seeding activity.

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Title: APOE isoform-associated tau oligomer polymorphs differ in synaptotoxicity and seeding activity.
Authors: Moreno N; Mitchell Center for Neurodegenerative Diseases, University of Texas Medical Branch, Galveston, Texas, USA.; Department of Neurology, Neuroscience, and Cell Biology, University of Texas Medical Branch, Galveston, Texas, USA., Shchankin N; Mitchell Center for Neurodegenerative Diseases, University of Texas Medical Branch, Galveston, Texas, USA.; Department of Neurology, Neuroscience, and Cell Biology, University of Texas Medical Branch, Galveston, Texas, USA., Fung L; Mitchell Center for Neurodegenerative Diseases, University of Texas Medical Branch, Galveston, Texas, USA.; Department of Neurology, Neuroscience, and Cell Biology, University of Texas Medical Branch, Galveston, Texas, USA., Puangmalai N; Mitchell Center for Neurodegenerative Diseases, University of Texas Medical Branch, Galveston, Texas, USA.; Department of Neurology, Neuroscience, and Cell Biology, University of Texas Medical Branch, Galveston, Texas, USA., Bhatt N; Mitchell Center for Neurodegenerative Diseases, University of Texas Medical Branch, Galveston, Texas, USA.; Department of Neurology, Neuroscience, and Cell Biology, University of Texas Medical Branch, Galveston, Texas, USA., Haque MA; Mitchell Center for Neurodegenerative Diseases, University of Texas Medical Branch, Galveston, Texas, USA.; Department of Neurology, Neuroscience, and Cell Biology, University of Texas Medical Branch, Galveston, Texas, USA., Zhao Y; Sealy Center for Molecular Medicine, University of Texas Medical Branch, Galveston, Texas, USA., Keene CD; Division of Neuropathology, University of Washington, Seattle, Washington, USA., Limon A; Mitchell Center for Neurodegenerative Diseases, University of Texas Medical Branch, Galveston, Texas, USA.; Department of Neurology, Neuroscience, and Cell Biology, University of Texas Medical Branch, Galveston, Texas, USA., Kayed R; Mitchell Center for Neurodegenerative Diseases, University of Texas Medical Branch, Galveston, Texas, USA.; Department of Neurology, Neuroscience, and Cell Biology, University of Texas Medical Branch, Galveston, Texas, USA.
Source: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2025 Dec; Vol. 21 (12), pp. e70965.
Publication Type: Journal Article
Journal Info: Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: APOE isoform-associated tau oligomer polymorphs differ in synaptotoxicity and seeding activity.
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  Data: <searchLink fieldCode="AU" term="%22Moreno+N%22">Moreno N</searchLink>; Mitchell Center for Neurodegenerative Diseases, University of Texas Medical Branch, Galveston, Texas, USA.; Department of Neurology, Neuroscience, and Cell Biology, University of Texas Medical Branch, Galveston, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Shchankin+N%22">Shchankin N</searchLink>; Mitchell Center for Neurodegenerative Diseases, University of Texas Medical Branch, Galveston, Texas, USA.; Department of Neurology, Neuroscience, and Cell Biology, University of Texas Medical Branch, Galveston, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Fung+L%22">Fung L</searchLink>; Mitchell Center for Neurodegenerative Diseases, University of Texas Medical Branch, Galveston, Texas, USA.; Department of Neurology, Neuroscience, and Cell Biology, University of Texas Medical Branch, Galveston, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Puangmalai+N%22">Puangmalai N</searchLink>; Mitchell Center for Neurodegenerative Diseases, University of Texas Medical Branch, Galveston, Texas, USA.; Department of Neurology, Neuroscience, and Cell Biology, University of Texas Medical Branch, Galveston, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Bhatt+N%22">Bhatt N</searchLink>; Mitchell Center for Neurodegenerative Diseases, University of Texas Medical Branch, Galveston, Texas, USA.; Department of Neurology, Neuroscience, and Cell Biology, University of Texas Medical Branch, Galveston, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Haque+MA%22">Haque MA</searchLink>; Mitchell Center for Neurodegenerative Diseases, University of Texas Medical Branch, Galveston, Texas, USA.; Department of Neurology, Neuroscience, and Cell Biology, University of Texas Medical Branch, Galveston, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Zhao+Y%22">Zhao Y</searchLink>; Sealy Center for Molecular Medicine, University of Texas Medical Branch, Galveston, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Keene+CD%22">Keene CD</searchLink>; Division of Neuropathology, University of Washington, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Limon+A%22">Limon A</searchLink>; Mitchell Center for Neurodegenerative Diseases, University of Texas Medical Branch, Galveston, Texas, USA.; Department of Neurology, Neuroscience, and Cell Biology, University of Texas Medical Branch, Galveston, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Kayed+R%22">Kayed R</searchLink>; Mitchell Center for Neurodegenerative Diseases, University of Texas Medical Branch, Galveston, Texas, USA.; Department of Neurology, Neuroscience, and Cell Biology, University of Texas Medical Branch, Galveston, Texas, USA.
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  Data: <searchLink fieldCode="JN" term="%22101231978%22">Alzheimer's & dementia : the journal of the Alzheimer's Association</searchLink> [Alzheimers Dement] 2025 Dec; Vol. 21 (12), pp. e70965.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22John+Wiley+%26+Sons%2C+Ltd%22">John Wiley & Sons, Ltd </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101231978 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1552-5279 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215525260%22">15525260 </searchLink><i>NLM ISO Abbreviation: </i>Alzheimers Dement <i>Subsets: </i>MEDLINE
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        Value: 10.1002/alz.70965
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            – D: 01
              M: 12
              Text: 2025 Dec
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