View in EDS

Inhibiting translation elongation by reducing eIF5A activity induces feedback inhibition of initiation, limiting tumour cell proliferation.

Saved in:
Bibliographic Details
Title: Inhibiting translation elongation by reducing eIF5A activity induces feedback inhibition of initiation, limiting tumour cell proliferation.
Authors: Sfakianos AP; MRC Toxicology Unit, University of Cambridge, Cambridge, UK. arissfak92@gmail.com., Raven RM; MRC Toxicology Unit, University of Cambridge, Cambridge, UK., Smith T; MRC Toxicology Unit, University of Cambridge, Cambridge, UK., Sun XM; MRC Toxicology Unit, University of Cambridge, Cambridge, UK., Mulroney TE; MRC Toxicology Unit, University of Cambridge, Cambridge, UK., Pizzinga M; MRC Toxicology Unit, University of Cambridge, Cambridge, UK., Dezi V; MRC Toxicology Unit, University of Cambridge, Cambridge, UK., Tenor AR; MRC Toxicology Unit, University of Cambridge, Cambridge, UK., Stoneley M; MRC Toxicology Unit, University of Cambridge, Cambridge, UK., Cole CH; MRC Toxicology Unit, University of Cambridge, Cambridge, UK., Al-Doori K; MRC Toxicology Unit, University of Cambridge, Cambridge, UK., Nur HA; MRC Toxicology Unit, University of Cambridge, Cambridge, UK., Pennie RL; Cancer Research UK Scotland Institute, Glasgow, UK., Powley I; Cancer Research UK Scotland Institute, Glasgow, UK., Officer-Jones L; Cancer Research UK Scotland Institute, Glasgow, UK., Sawarkar R; MRC Toxicology Unit, University of Cambridge, Cambridge, UK., Turner M; The Babraham Institute, Babraham Research Campus, Cambridge, UK., MacFarlane M; MRC Toxicology Unit, University of Cambridge, Cambridge, UK., Sansom OJ; Cancer Research UK Scotland Institute, Glasgow, UK.; School of Cancer Sciences, University of Glasgow, Glasgow, UK., Bushell M; Cancer Research UK Scotland Institute, Glasgow, UK.; School of Cancer Sciences, University of Glasgow, Glasgow, UK., Le Quesne J; Cancer Research UK Scotland Institute, Glasgow, UK.; School of Cancer Sciences, University of Glasgow, Glasgow, UK., Harvey RF; MRC Toxicology Unit, University of Cambridge, Cambridge, UK. rfh32@mrc-tox.cam.ac.uk., Willis AE; MRC Toxicology Unit, University of Cambridge, Cambridge, UK. aew80@mrc-tox.cam.ac.uk.
Source: Nature communications [Nat Commun] 2025 Dec 13; Vol. 16 (1), pp. 11486. Date of Electronic Publication: 2025 Dec 13.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
  Availability: 0
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 41390489
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Inhibiting translation elongation by reducing eIF5A activity induces feedback inhibition of initiation, limiting tumour cell proliferation.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Sfakianos+AP%22">Sfakianos AP</searchLink>; MRC Toxicology Unit, University of Cambridge, Cambridge, UK. arissfak92@gmail.com.<br /><searchLink fieldCode="AU" term="%22Raven+RM%22">Raven RM</searchLink>; MRC Toxicology Unit, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Smith+T%22">Smith T</searchLink>; MRC Toxicology Unit, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Sun+XM%22">Sun XM</searchLink>; MRC Toxicology Unit, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Mulroney+TE%22">Mulroney TE</searchLink>; MRC Toxicology Unit, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Pizzinga+M%22">Pizzinga M</searchLink>; MRC Toxicology Unit, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Dezi+V%22">Dezi V</searchLink>; MRC Toxicology Unit, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Tenor+AR%22">Tenor AR</searchLink>; MRC Toxicology Unit, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Stoneley+M%22">Stoneley M</searchLink>; MRC Toxicology Unit, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Cole+CH%22">Cole CH</searchLink>; MRC Toxicology Unit, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Al-Doori+K%22">Al-Doori K</searchLink>; MRC Toxicology Unit, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Nur+HA%22">Nur HA</searchLink>; MRC Toxicology Unit, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Pennie+RL%22">Pennie RL</searchLink>; Cancer Research UK Scotland Institute, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Powley+I%22">Powley I</searchLink>; Cancer Research UK Scotland Institute, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Officer-Jones+L%22">Officer-Jones L</searchLink>; Cancer Research UK Scotland Institute, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Sawarkar+R%22">Sawarkar R</searchLink>; MRC Toxicology Unit, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Turner+M%22">Turner M</searchLink>; The Babraham Institute, Babraham Research Campus, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22MacFarlane+M%22">MacFarlane M</searchLink>; MRC Toxicology Unit, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Sansom+OJ%22">Sansom OJ</searchLink>; Cancer Research UK Scotland Institute, Glasgow, UK.; School of Cancer Sciences, University of Glasgow, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Bushell+M%22">Bushell M</searchLink>; Cancer Research UK Scotland Institute, Glasgow, UK.; School of Cancer Sciences, University of Glasgow, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Le+Quesne+J%22">Le Quesne J</searchLink>; Cancer Research UK Scotland Institute, Glasgow, UK.; School of Cancer Sciences, University of Glasgow, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Harvey+RF%22">Harvey RF</searchLink>; MRC Toxicology Unit, University of Cambridge, Cambridge, UK. rfh32@mrc-tox.cam.ac.uk.<br /><searchLink fieldCode="AU" term="%22Willis+AE%22">Willis AE</searchLink>; MRC Toxicology Unit, University of Cambridge, Cambridge, UK. aew80@mrc-tox.cam.ac.uk.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2025 Dec 13; Vol. 16 (1), pp. 11486. <i>Date of Electronic Publication: </i>2025 Dec 13.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Group%22">Nature Pub. Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101528555 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2041-1723 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220411723%22">20411723 </searchLink><i>NLM ISO Abbreviation: </i>Nat Commun <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41390489
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1038/s41467-025-66531-z
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 11486
    Titles:
      – TitleFull: Inhibiting translation elongation by reducing eIF5A activity induces feedback inhibition of initiation, limiting tumour cell proliferation.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Sfakianos AP
      – PersonEntity:
          Name:
            NameFull: Raven RM
      – PersonEntity:
          Name:
            NameFull: Smith T
      – PersonEntity:
          Name:
            NameFull: Sun XM
      – PersonEntity:
          Name:
            NameFull: Mulroney TE
      – PersonEntity:
          Name:
            NameFull: Pizzinga M
      – PersonEntity:
          Name:
            NameFull: Dezi V
      – PersonEntity:
          Name:
            NameFull: Tenor AR
      – PersonEntity:
          Name:
            NameFull: Stoneley M
      – PersonEntity:
          Name:
            NameFull: Cole CH
      – PersonEntity:
          Name:
            NameFull: Al-Doori K
      – PersonEntity:
          Name:
            NameFull: Nur HA
      – PersonEntity:
          Name:
            NameFull: Pennie RL
      – PersonEntity:
          Name:
            NameFull: Powley I
      – PersonEntity:
          Name:
            NameFull: Officer-Jones L
      – PersonEntity:
          Name:
            NameFull: Sawarkar R
      – PersonEntity:
          Name:
            NameFull: Turner M
      – PersonEntity:
          Name:
            NameFull: MacFarlane M
      – PersonEntity:
          Name:
            NameFull: Sansom OJ
      – PersonEntity:
          Name:
            NameFull: Bushell M
      – PersonEntity:
          Name:
            NameFull: Le Quesne J
      – PersonEntity:
          Name:
            NameFull: Harvey RF
      – PersonEntity:
          Name:
            NameFull: Willis AE
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 13
              M: 12
              Text: 2025 Dec 13
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-electronic
              Value: 2041-1723
          Numbering:
            – Type: volume
              Value: 16
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: Nature communications
              Type: main
ResultId 1