What is the clinical and cost-effectiveness of surgery with Medial Opening wedge high TIbial Osteotomy compared with Non-surgical treatment (MOTION) in the management of osteoarthritis of the knee in patients younger than 60 years? : a protocol for a multicentre, randomized controlled trial.

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Title: What is the clinical and cost-effectiveness of surgery with Medial Opening wedge high TIbial Osteotomy compared with Non-surgical treatment (MOTION) in the management of osteoarthritis of the knee in patients younger than 60 years? : a protocol for a multicentre, randomized controlled trial.
Authors: Amin AK; Edinburgh Orthopaedics, Royal Infirmary of Edinburgh, Edinburgh, UK., Locherty R; Usher Institute, University of Edinburgh, Edinburgh, UK., Agarwal N; Edinburgh Orthopaedics, Royal Infirmary of Edinburgh, Edinburgh, UK., Rickman H; Usher Institute, University of Edinburgh, Edinburgh, UK., Metcalfe A; University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK.; Warwick Medical School, University of Warwick, Coventry, UK., Blyth MJG; Department of Orthopaedics, Glasgow Royal Infirmary, Glasgow, UK., Scott CEH; Edinburgh Orthopaedics, Royal Infirmary of Edinburgh, Edinburgh, UK.; Bone & Joint Research , London, UK., Clement ND; Edinburgh Orthopaedics, Royal Infirmary of Edinburgh, Edinburgh, UK., Miller M; Usher Institute, University of Edinburgh, Edinburgh, UK., Dobbie F; Usher Institute, University of Edinburgh, Edinburgh, UK., Stoddart A; Usher Institute, University of Edinburgh, Edinburgh, UK., Hamilton DF; Research Centre for Health, Glasgow Caledonian University, Glasgow, UK., Ralston SH; Centre for Genomic & Experimental Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK., Lewis S; Usher Institute, University of Edinburgh, Edinburgh, UK., Duckworth AD; Edinburgh Orthopaedics, Royal Infirmary of Edinburgh, Edinburgh, UK.; Usher Institute, University of Edinburgh, Edinburgh, UK.
Source: Bone & joint open [Bone Jt Open] 2025 Dec 15; Vol. 6 (12), pp. 1598-1610. Date of Electronic Publication: 2025 Dec 15.
Publication Type: Journal Article
Journal Info: Publisher: The British Editorial Society of Bone & Joint Surgery Country of Publication: England NLM ID: 101770336 Publication Model: Electronic Cited Medium: Internet ISSN: 2633-1462 (Electronic) Linking ISSN: 26331462 NLM ISO Abbreviation: Bone Jt Open Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2633-1462
DOI:10.1302/2633-1462.612.BJO-2025-0185.R1