A bispecific antibody designed to act as a NRP2/PLXNA1 agonist mimics anticancer activity of SEMA3F.

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Bibliographic Details
Title: A bispecific antibody designed to act as a NRP2/PLXNA1 agonist mimics anticancer activity of SEMA3F.
Authors: Tian H; IAS HKUST-Scripps R&D Laboratory, Institute for Advanced Study, Hong Kong University of Science and Technology, Kowloon, Hong Kong, China; Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong, China; Pangu Biopharma, Hong Kong, China., Fung CP; IAS HKUST-Scripps R&D Laboratory, Institute for Advanced Study, Hong Kong University of Science and Technology, Kowloon, Hong Kong, China; Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong, China; Pangu Biopharma, Hong Kong, China., Burman L; aTyr Pharma, San Diego, California, USA., Chong YE; aTyr Pharma, San Diego, California, USA., Liu C; Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong, China., Geng Y; IAS HKUST-Scripps R&D Laboratory, Institute for Advanced Study, Hong Kong University of Science and Technology, Kowloon, Hong Kong, China; Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong, China; Pangu Biopharma, Hong Kong, China., Yang L; IAS HKUST-Scripps R&D Laboratory, Institute for Advanced Study, Hong Kong University of Science and Technology, Kowloon, Hong Kong, China; Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong, China; Pangu Biopharma, Hong Kong, China., Chow MW; IAS HKUST-Scripps R&D Laboratory, Institute for Advanced Study, Hong Kong University of Science and Technology, Kowloon, Hong Kong, China; Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong, China; Pangu Biopharma, Hong Kong, China., Zhang Y; Biological Cryo-EM Center, The Hong Kong University of Science and Technology, Hong Kong, China., Ho KWH; Biological Cryo-EM Center, The Hong Kong University of Science and Technology, Hong Kong, China., Zhu G; Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong, China., Wu Z; Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong, China., Yang XL; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, USA., Xu Z; aTyr Pharma, San Diego, California, USA., Nangle LA; aTyr Pharma, San Diego, California, USA. Electronic address: lnangle@atyrpharma.com.
Source: The Journal of biological chemistry [J Biol Chem] 2026 Feb; Vol. 302 (2), pp. 111056. Date of Electronic Publication: 2025 Dec 13.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1083-351X
DOI:10.1016/j.jbc.2025.111056