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A bispecific antibody designed to act as a NRP2/PLXNA1 agonist mimics anticancer activity of SEMA3F.

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Title: A bispecific antibody designed to act as a NRP2/PLXNA1 agonist mimics anticancer activity of SEMA3F.
Authors: Tian H; IAS HKUST-Scripps R&D Laboratory, Institute for Advanced Study, Hong Kong University of Science and Technology, Kowloon, Hong Kong, China; Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong, China; Pangu Biopharma, Hong Kong, China., Fung CP; IAS HKUST-Scripps R&D Laboratory, Institute for Advanced Study, Hong Kong University of Science and Technology, Kowloon, Hong Kong, China; Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong, China; Pangu Biopharma, Hong Kong, China., Burman L; aTyr Pharma, San Diego, California, USA., Chong YE; aTyr Pharma, San Diego, California, USA., Liu C; Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong, China., Geng Y; IAS HKUST-Scripps R&D Laboratory, Institute for Advanced Study, Hong Kong University of Science and Technology, Kowloon, Hong Kong, China; Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong, China; Pangu Biopharma, Hong Kong, China., Yang L; IAS HKUST-Scripps R&D Laboratory, Institute for Advanced Study, Hong Kong University of Science and Technology, Kowloon, Hong Kong, China; Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong, China; Pangu Biopharma, Hong Kong, China., Chow MW; IAS HKUST-Scripps R&D Laboratory, Institute for Advanced Study, Hong Kong University of Science and Technology, Kowloon, Hong Kong, China; Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong, China; Pangu Biopharma, Hong Kong, China., Zhang Y; Biological Cryo-EM Center, The Hong Kong University of Science and Technology, Hong Kong, China., Ho KWH; Biological Cryo-EM Center, The Hong Kong University of Science and Technology, Hong Kong, China., Zhu G; Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong, China., Wu Z; Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong, China., Yang XL; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, USA., Xu Z; aTyr Pharma, San Diego, California, USA., Nangle LA; aTyr Pharma, San Diego, California, USA. Electronic address: lnangle@atyrpharma.com.
Source: The Journal of biological chemistry [J Biol Chem] 2026 Feb; Vol. 302 (2), pp. 111056. Date of Electronic Publication: 2025 Dec 13.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
PubTypeId: academicJournal
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  Data: A bispecific antibody designed to act as a NRP2/PLXNA1 agonist mimics anticancer activity of SEMA3F.
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  Data: <searchLink fieldCode="AU" term="%22Tian+H%22">Tian H</searchLink>; IAS HKUST-Scripps R&D Laboratory, Institute for Advanced Study, Hong Kong University of Science and Technology, Kowloon, Hong Kong, China; Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong, China; Pangu Biopharma, Hong Kong, China.<br /><searchLink fieldCode="AU" term="%22Fung+CP%22">Fung CP</searchLink>; IAS HKUST-Scripps R&D Laboratory, Institute for Advanced Study, Hong Kong University of Science and Technology, Kowloon, Hong Kong, China; Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong, China; Pangu Biopharma, Hong Kong, China.<br /><searchLink fieldCode="AU" term="%22Burman+L%22">Burman L</searchLink>; aTyr Pharma, San Diego, California, USA.<br /><searchLink fieldCode="AU" term="%22Chong+YE%22">Chong YE</searchLink>; aTyr Pharma, San Diego, California, USA.<br /><searchLink fieldCode="AU" term="%22Liu+C%22">Liu C</searchLink>; Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong, China.<br /><searchLink fieldCode="AU" term="%22Geng+Y%22">Geng Y</searchLink>; IAS HKUST-Scripps R&D Laboratory, Institute for Advanced Study, Hong Kong University of Science and Technology, Kowloon, Hong Kong, China; Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong, China; Pangu Biopharma, Hong Kong, China.<br /><searchLink fieldCode="AU" term="%22Yang+L%22">Yang L</searchLink>; IAS HKUST-Scripps R&D Laboratory, Institute for Advanced Study, Hong Kong University of Science and Technology, Kowloon, Hong Kong, China; Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong, China; Pangu Biopharma, Hong Kong, China.<br /><searchLink fieldCode="AU" term="%22Chow+MW%22">Chow MW</searchLink>; IAS HKUST-Scripps R&D Laboratory, Institute for Advanced Study, Hong Kong University of Science and Technology, Kowloon, Hong Kong, China; Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong, China; Pangu Biopharma, Hong Kong, China.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Biological Cryo-EM Center, The Hong Kong University of Science and Technology, Hong Kong, China.<br /><searchLink fieldCode="AU" term="%22Ho+KWH%22">Ho KWH</searchLink>; Biological Cryo-EM Center, The Hong Kong University of Science and Technology, Hong Kong, China.<br /><searchLink fieldCode="AU" term="%22Zhu+G%22">Zhu G</searchLink>; Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong, China.<br /><searchLink fieldCode="AU" term="%22Wu+Z%22">Wu Z</searchLink>; Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong, China.<br /><searchLink fieldCode="AU" term="%22Yang+XL%22">Yang XL</searchLink>; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, USA.<br /><searchLink fieldCode="AU" term="%22Xu+Z%22">Xu Z</searchLink>; aTyr Pharma, San Diego, California, USA.<br /><searchLink fieldCode="AU" term="%22Nangle+LA%22">Nangle LA</searchLink>; aTyr Pharma, San Diego, California, USA. Electronic address: lnangle@atyrpharma.com.
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  Data: <searchLink fieldCode="JN" term="%222985121R%22">The Journal of biological chemistry</searchLink> [J Biol Chem] 2026 Feb; Vol. 302 (2), pp. 111056. <i>Date of Electronic Publication: </i>2025 Dec 13.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Inc%2E+on+behalf+of+American+Society+for+Biochemistry+and+Molecular+Biology%22">Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>2985121R <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1083-351X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200219258%22">00219258 </searchLink><i>NLM ISO Abbreviation: </i>J Biol Chem <i>Subsets: </i>MEDLINE
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      – Type: doi
        Value: 10.1016/j.jbc.2025.111056
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      – Code: eng
        Text: English
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        StartPage: 111056
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      – TitleFull: A bispecific antibody designed to act as a NRP2/PLXNA1 agonist mimics anticancer activity of SEMA3F.
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              Text: 2026 Feb
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