Overactive Neuronal eEF2K/eEF2 signaling is associated with cognitive impairment and apathy-like behavior.

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Title: Overactive Neuronal eEF2K/eEF2 signaling is associated with cognitive impairment and apathy-like behavior.
Authors: Jester HM; Department of Internal Medicine-Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, NC, 27157, USA., Nicol N; Department of Internal Medicine-Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, NC, 27157, USA., Yang Q; Department of Internal Medicine-Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, NC, 27157, USA., Zhang Y; Department of Internal Medicine-Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, NC, 27157, USA., Suhocki A; Department of Internal Medicine-Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, NC, 27157, USA., Zhou X; Department of Internal Medicine-Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, NC, 27157, USA., Underwood E; Department of Internal Medicine-Section on Molecular Medicine, Wake Forest School of Medicine, Winston-Salem, NC, 27157, USA., Pourhadi H; Department of Internal Medicine-Section on Molecular Medicine, Wake Forest School of Medicine, Winston-Salem, NC, 27157, USA., Cheng D; Department of Cancer Biology, Wake Forest Baptist Comprehensive Cancer Center, Wake Forest School of Medicine, Winston-Salem, NC, 27157, USA., Lee J; Department of Internal Medicine-Section on Molecular Medicine, Wake Forest School of Medicine, Winston-Salem, NC, 27157, USA., Sun P; Department of Cancer Biology, Wake Forest Baptist Comprehensive Cancer Center, Wake Forest School of Medicine, Winston-Salem, NC, 27157, USA., Furdui CM; Department of Internal Medicine-Section on Molecular Medicine, Wake Forest School of Medicine, Winston-Salem, NC, 27157, USA., Proud CG; Lifelong Health, South Australian Health and Medical Research Institute, Adelaide, SA, 5001, Australia., Rosenblum K; Sagol Department of Neurobiology, University of Haifa, 3498838, Haifa, Israel., Ma T; Department of Internal Medicine-Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, NC, 27157, USA. tao.ma@wfusm.edu.; Department of Translational Neuroscience, Wake Forest School of Medicine, Winston-Salem, NC, 27157, USA. tao.ma@wfusm.edu.
Source: Molecular psychiatry [Mol Psychiatry] 2026 May; Vol. 31 (5), pp. 2454-2471. Date of Electronic Publication: 2025 Dec 14.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Specialist Journals Country of Publication: England NLM ID: 9607835 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5578 (Electronic) Linking ISSN: 13594184 NLM ISO Abbreviation: Mol Psychiatry Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1476-5578
DOI:10.1038/s41380-025-03408-z