In silico docking yields small molecule negative allosteric modulators targeting the core of Frizzled 7.
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| Title: | In silico docking yields small molecule negative allosteric modulators targeting the core of Frizzled 7. |
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| Authors: | Scharf MM; Department of Physiology & Pharmacology, Sec Receptor Biology & Signaling, Biomedicum, Karolinska Institute, Stockholm, Sweden., Kinsolving J; Department of Physiology & Pharmacology, Sec Receptor Biology & Signaling, Biomedicum, Karolinska Institute, Stockholm, Sweden., Grätz L; Department of Physiology & Pharmacology, Sec Receptor Biology & Signaling, Biomedicum, Karolinska Institute, Stockholm, Sweden.; Molecular, Cellular and Pharmacobiology Section, Institute of Pharmaceutical Biology, University of Bonn, Bonn, Germany., Voss JH; Department of Physiology & Pharmacology, Sec Receptor Biology & Signaling, Biomedicum, Karolinska Institute, Stockholm, Sweden., Carrasco-Busturia D; Division of Theoretical Chemistry and Biology, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, Stockholm, Sweden., Forsberg B; Department of Physics, Chemistry and Biology, SciLifeLab, Linköping University, Linköping, Sweden., Kolb P; Philipps-Universität Marburg, Institute of Pharmaceutical Chemistry, Marburg, Germany., Schulte G; Department of Physiology & Pharmacology, Sec Receptor Biology & Signaling, Biomedicum, Karolinska Institute, Stockholm, Sweden. gunnar.schulte@ki.se. |
| Source: | Nature communications [Nat Commun] 2025 Dec 14; Vol. 16 (1), pp. 11138. Date of Electronic Publication: 2025 Dec 14. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-025-67147-z |
