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Dual-targeted ping-pong CAR T cells: Leveraging peripheral expansion to improve solid tumor immunotherapy.

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Title: Dual-targeted ping-pong CAR T cells: Leveraging peripheral expansion to improve solid tumor immunotherapy.
Authors: Finck AV; Department of Pathology and Laboratory Medicine, Center for Cellular Immunotherapies, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104.; Parker Institute for Cancer Immunotherapy at University of Pennsylvania, Philadelphia, PA 19104., Wang Z; Department of Pathology and Laboratory Medicine, Center for Cellular Immunotherapies, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104.; Parker Institute for Cancer Immunotherapy at University of Pennsylvania, Philadelphia, PA 19104., Gonzales D; Department of Pathology and Laboratory Medicine, Center for Cellular Immunotherapies, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104.; Parker Institute for Cancer Immunotherapy at University of Pennsylvania, Philadelphia, PA 19104., Wellhausen N; Department of Pathology and Laboratory Medicine, Center for Cellular Immunotherapies, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104.; Parker Institute for Cancer Immunotherapy at University of Pennsylvania, Philadelphia, PA 19104., Castelli S; Department of Pathology and Laboratory Medicine, Center for Cellular Immunotherapies, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104.; Parker Institute for Cancer Immunotherapy at University of Pennsylvania, Philadelphia, PA 19104., Banerjee E; Comparative Pathology Core, Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104., Aznar MA; Department of Pathology and Laboratory Medicine, Center for Cellular Immunotherapies, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104.; Parker Institute for Cancer Immunotherapy at University of Pennsylvania, Philadelphia, PA 19104., Young RM; Department of Pathology and Laboratory Medicine, Center for Cellular Immunotherapies, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104.; Parker Institute for Cancer Immunotherapy at University of Pennsylvania, Philadelphia, PA 19104., June CH; Department of Pathology and Laboratory Medicine, Center for Cellular Immunotherapies, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104.; Parker Institute for Cancer Immunotherapy at University of Pennsylvania, Philadelphia, PA 19104.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2025 Dec 23; Vol. 122 (51), pp. e2518996122. Date of Electronic Publication: 2025 Dec 15.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Finck+AV%22">Finck AV</searchLink>; Department of Pathology and Laboratory Medicine, Center for Cellular Immunotherapies, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104.; Parker Institute for Cancer Immunotherapy at University of Pennsylvania, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22Wang+Z%22">Wang Z</searchLink>; Department of Pathology and Laboratory Medicine, Center for Cellular Immunotherapies, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104.; Parker Institute for Cancer Immunotherapy at University of Pennsylvania, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22Gonzales+D%22">Gonzales D</searchLink>; Department of Pathology and Laboratory Medicine, Center for Cellular Immunotherapies, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104.; Parker Institute for Cancer Immunotherapy at University of Pennsylvania, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22Wellhausen+N%22">Wellhausen N</searchLink>; Department of Pathology and Laboratory Medicine, Center for Cellular Immunotherapies, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104.; Parker Institute for Cancer Immunotherapy at University of Pennsylvania, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22Castelli+S%22">Castelli S</searchLink>; Department of Pathology and Laboratory Medicine, Center for Cellular Immunotherapies, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104.; Parker Institute for Cancer Immunotherapy at University of Pennsylvania, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22Banerjee+E%22">Banerjee E</searchLink>; Comparative Pathology Core, Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22Aznar+MA%22">Aznar MA</searchLink>; Department of Pathology and Laboratory Medicine, Center for Cellular Immunotherapies, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104.; Parker Institute for Cancer Immunotherapy at University of Pennsylvania, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22Young+RM%22">Young RM</searchLink>; Department of Pathology and Laboratory Medicine, Center for Cellular Immunotherapies, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104.; Parker Institute for Cancer Immunotherapy at University of Pennsylvania, Philadelphia, PA 19104.<br /><searchLink fieldCode="AU" term="%22June+CH%22">June CH</searchLink>; Department of Pathology and Laboratory Medicine, Center for Cellular Immunotherapies, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104.; Parker Institute for Cancer Immunotherapy at University of Pennsylvania, Philadelphia, PA 19104.
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  Data: <searchLink fieldCode="JN" term="%227505876%22">Proceedings of the National Academy of Sciences of the United States of America</searchLink> [Proc Natl Acad Sci U S A] 2025 Dec 23; Vol. 122 (51), pp. e2518996122. <i>Date of Electronic Publication: </i>2025 Dec 15.
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