Dual-targeted ping-pong CAR T cells: Leveraging peripheral expansion to improve solid tumor immunotherapy.

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Title: Dual-targeted ping-pong CAR T cells: Leveraging peripheral expansion to improve solid tumor immunotherapy.
Authors: Finck AV; Department of Pathology and Laboratory Medicine, Center for Cellular Immunotherapies, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104.; Parker Institute for Cancer Immunotherapy at University of Pennsylvania, Philadelphia, PA 19104., Wang Z; Department of Pathology and Laboratory Medicine, Center for Cellular Immunotherapies, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104.; Parker Institute for Cancer Immunotherapy at University of Pennsylvania, Philadelphia, PA 19104., Gonzales D; Department of Pathology and Laboratory Medicine, Center for Cellular Immunotherapies, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104.; Parker Institute for Cancer Immunotherapy at University of Pennsylvania, Philadelphia, PA 19104., Wellhausen N; Department of Pathology and Laboratory Medicine, Center for Cellular Immunotherapies, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104.; Parker Institute for Cancer Immunotherapy at University of Pennsylvania, Philadelphia, PA 19104., Castelli S; Department of Pathology and Laboratory Medicine, Center for Cellular Immunotherapies, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104.; Parker Institute for Cancer Immunotherapy at University of Pennsylvania, Philadelphia, PA 19104., Banerjee E; Comparative Pathology Core, Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104., Aznar MA; Department of Pathology and Laboratory Medicine, Center for Cellular Immunotherapies, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104.; Parker Institute for Cancer Immunotherapy at University of Pennsylvania, Philadelphia, PA 19104., Young RM; Department of Pathology and Laboratory Medicine, Center for Cellular Immunotherapies, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104.; Parker Institute for Cancer Immunotherapy at University of Pennsylvania, Philadelphia, PA 19104., June CH; Department of Pathology and Laboratory Medicine, Center for Cellular Immunotherapies, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104.; Parker Institute for Cancer Immunotherapy at University of Pennsylvania, Philadelphia, PA 19104.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2025 Dec 23; Vol. 122 (51), pp. e2518996122. Date of Electronic Publication: 2025 Dec 15.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1091-6490
DOI:10.1073/pnas.2518996122